Exploring the Utility of Expanded Clinical Exome Sequencing in Cancer Patients with Pesticide Exposure: Insights from Blood Samples DOI Creative Commons

Hemily Gonçalves Ribeiro,

Miller Caldas Barradas,

Fernanda Ribeiro Godoy

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 11, 2023

Abstract Brazil is a major pesticide consumer with evident problems in regulation and supervision of such products. Thus, evaluating the impact pesticides on human health pivotal to understanding their relationship disease development progression. In this context, we aimed assess panel molecular pathways associated cancer susceptibility, as well exposure lifestyle profile group Brazilian farmers occupationally exposed pesticides. We performed clinical exome sequencing 31 diagnosed presenting history exposure. Using Emedgene software (Illumina), categorized compilation candidate disease-related genes evaluated them discern crucial carcinogenesis. Consequently, successfully pinpointed that should be regarded potential risk factors when carcinogenic environment. Our analysis suggests an important role extracellular matrix related along some classical findings DNA repair mechanisms. The tumor microenvironment emerges promising area investigation and, future studies consider its

Language: Английский

Ginsenoside Rg3 Improved Age-Related Macular Degeneration Through Inhibiting ROS-Mediated Mitochondrion-Dependent Apoptosis In Vivo and In Vitro DOI Open Access

Rui‐yi Hu,

Si-min Qi,

Yajun Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11414 - 11414

Published: Oct. 24, 2024

Age-related macular degeneration (AMD) is marked by a progressive loss of central vision and the third leading cause irreversible blindness worldwide. The exact mechanisms driving progression this degenerative condition remain elusive, as now, there are no available preventative measures for dry AMD. According to ancient records, ginseng affects eyes brightening them enhancing wisdom. Modern pharmacological research shows that active ingredients in ginseng, ginsenosides, may be used prevent or improve eye diseases threaten vision. Some articles have reported ginsenoside Rg3 can treat diabetic retinopathy mice, but reports exist on its effects Therefore, role mechanism AMD warrant further study. This study aims investigate underlying molecular mechanisms. We established mouse model examine impact NaIO

Language: Английский

Citations

2
Utilizing Bioinformatics Approaches to Conduct a Comparative Analysis of the Thyroid Transcriptome in Thyroid Disorders DOI Creative Commons
Luís Jesuíno de Oliveira Andrade, Luís Matos de Oliveira, Alcina Maria Vinhaes Bittencourt

et al.

Revista Colombiana de Endocrinología Diabetes & Metabolismo, Journal Year: 2024, Volume and Issue: 11(1)

Published: March 18, 2024

Introduction: This study aims to identify common gene expression patterns and dysregulated pathways in various thyroid disorders by leveraging publicly available transcriptomic datasets. The integration of other omics data, when possible, will allow us uncover potential molecular drivers biomarkers associated with specific dysfunctions. However, there are still gaps the analysis transcriptomes disorders. Objective: To conduct a comparative transcriptome using bioinformatics approaches. Methods: We retrieved datasets related from European Nucleotide Archive. Data preprocessing involved conducting quality control, trimming reads, aligning them reference genome. Differential was performed packages, finally, functional enrichment conducted gain insights into biological processes. Network explore interactions regulatory relationships among differentially expressed genes (DEGs). Results: Our included total 18 datasets, which 15 were selected based on inclusion criteria assessment. Numerous exhibiting differential (P < 0.01) discerned, their significance systematically ranked. Functional revealed numerous processes genes, providing mechanisms Cytoscape software identified key hub therapeutic targets. Conclusion: demonstrates an accessible methodology for different without need tissue samples. approaches provides comprehensive understanding underlying diseases.

Language: Английский

Citations

1
Bioinformatics-Driven Discovery of Signaling Pathways and Genes Influencing Cervical Cancer DOI
Anooja Ali,

J. S. Shyam Mohan,

Tousif Ahamed Allabksha Nadaf

et al.

SN Computer Science, Journal Year: 2024, Volume and Issue: 5(8)

Published: Oct. 26, 2024

Language: Английский

Citations

1
Screening and identification of susceptibility genes for cervical cancer via bioinformatics analysis and the construction of an mitophagy-related genes diagnostic model DOI Creative Commons
Zhang Zhang, Fangfang Chen, Xiaoxiao Deng

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(9)

Published: Sept. 19, 2024

Language: Английский

Citations

0
Utilizing Bioinformatics Approaches to Conduct Comparative Analysis of the Thyroid Transcriptome in Thyroid Disorders DOI Creative Commons
Luís Jesuíno de Oliveira Andrade, Luís Matos de Oliveira, Alcina Maria Vinhaes Bittencourt

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 29, 2023

Abstract Introduction : This study aims to identify common gene expression patterns and dysregulated pathways in various thyroid disorders by leveraging publicly available transcriptomic datasets. The integration of other omics data, when possible, will allow us uncover potential molecular drivers biomarkers associated with specific dysfunctions. However, there are still gaps the analysis transcriptomes disorders. Objective To conduct a comparative transcriptome using bioinformatics approaches. Methods We retrieved datasets related from European Nucleotide Archive. Data preprocessing involved conducting quality control, trimming reads, aligning them reference genome. Differential was performed packages, functional enrichment conducted gain insights into biological processes. Network explore interactions regulatory relationships among differentially expressed genes (DEGs). Results Our included total 18 datasets, which 15 were selected based on inclusion criteria assessment. A large number DEGs identified (p < 0.01), these ranked according their significance. Functional revealed numerous processes DEGs, providing mechanisms Cytoscape software key hub therapeutic targets. Conclusion demonstrates an accessible methodology for different without need tissue samples. approaches provides comprehensive understanding underlying diseases.

Language: Английский

Citations

0
Exploring the Utility of Expanded Clinical Exome Sequencing in Cancer Patients with Pesticide Exposure: Insights from Blood Samples DOI Creative Commons

Hemily Gonçalves Ribeiro,

Miller Caldas Barradas,

Fernanda Ribeiro Godoy

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 11, 2023

Abstract Brazil is a major pesticide consumer with evident problems in regulation and supervision of such products. Thus, evaluating the impact pesticides on human health pivotal to understanding their relationship disease development progression. In this context, we aimed assess panel molecular pathways associated cancer susceptibility, as well exposure lifestyle profile group Brazilian farmers occupationally exposed pesticides. We performed clinical exome sequencing 31 diagnosed presenting history exposure. Using Emedgene software (Illumina), categorized compilation candidate disease-related genes evaluated them discern crucial carcinogenesis. Consequently, successfully pinpointed that should be regarded potential risk factors when carcinogenic environment. Our analysis suggests an important role extracellular matrix related along some classical findings DNA repair mechanisms. The tumor microenvironment emerges promising area investigation and, future studies consider its

Language: Английский

Citations

0