Flavin mononucleotide, a potent inhibitor of insulin-degrading enzyme: an in-silico study DOI
Nitish Kumar, Komalpreet Kaur,

Anupmjot Kaur Jassal

et al.

Journal of Biomolecular Structure and Dynamics, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Dec. 11, 2024

Diabetes Mellitus is a metabolic disorder which has affected over 476 million people globally with projections indicating further increase in this number. Despite the availability of treatment therapies, maintaining optimal blood glucose levels remains critical task. During literature survey, we came across Insulin degrading enzyme (IDE) responsible for insulin degradation body and inhibition could bioavailability body. Therefore, library phytoconstituents isolated from anti-diabetic plants was prepared screened against IDE by using various

Language: Английский

Exploring the Influence of Acetylenic Acetogenin Unsaturation Patterns on Lipid Interface Interactions: Insights from Surface Chemistry, Rheology, and Spectroscopy DOI Creative Commons
Matheus Elias Rosa,

Ivanildo A. Brito,

João Henrique G. Lago

et al.

Results in Surfaces and Interfaces, Journal Year: 2024, Volume and Issue: unknown, P. 100306 - 100306

Published: Sept. 1, 2024

Language: Английский

Citations

1
The Whole Genome DNA Methylation Signatures of Hindlimb Muscles in Chinese Alligators during Hibernation and Active Periods DOI Creative Commons
Jihui Zhang,

Xiaobing Wu

Animals, Journal Year: 2024, Volume and Issue: 14(13), P. 1972 - 1972

Published: July 3, 2024

Many ectotherms hibernate to increase their chances of survival during harsh winter conditions. The role DNA methylation in regulating gene expression related hibernation remains unclear. Here, we employed whole-genome bisulfite sequencing (WGBS) technology construct a comprehensive genome-wide landscape the hindlimb muscles Chinese alligator and active periods. results indicated that modifications were most abundant at CG sites, identifying 9447 differentially methylated regions (DMRs) 2329 genes (DMGs). KEGG pathway enrichment analysis DMGs revealed significant major pathways such as neurotrophin signaling pathway, MAPK GnRH biosynthesis amino acids, regulation actin cytoskeleton, which are closely lipid metabolism, energy acid metabolism. Among these, 412 located promoter regions, including metabolism ATP5F1C, ATP5MD, PDK3, ANGPTL1, ANGPTL2, ubiquitin-proteasome degradation FBXO28, FBXO43, KLHL40, PSMD5. These findings suggest may play adaptive mechanisms alligator. This study contributes further understanding epigenetic behind

Language: Английский

Citations

0
Flavonoid-rich fraction of Monodora tenuifolia Benth seeds improves antioxidant status in male Wistar rats with streptozotocin-induced Diabetes mellitus DOI Creative Commons

Samuel Nzekwe,

Adetoun Elizabeth Morakinyo, Monde Ntwasa

et al.

Phytomedicine Plus, Journal Year: 2024, Volume and Issue: unknown, P. 100646 - 100646

Published: Oct. 1, 2024

Language: Английский

Citations

0
Flavin mononucleotide, a potent inhibitor of insulin-degrading enzyme: an in-silico study DOI
Nitish Kumar, Komalpreet Kaur,

Anupmjot Kaur Jassal

et al.

Journal of Biomolecular Structure and Dynamics, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Dec. 11, 2024

Diabetes Mellitus is a metabolic disorder which has affected over 476 million people globally with projections indicating further increase in this number. Despite the availability of treatment therapies, maintaining optimal blood glucose levels remains critical task. During literature survey, we came across Insulin degrading enzyme (IDE) responsible for insulin degradation body and inhibition could bioavailability body. Therefore, library phytoconstituents isolated from anti-diabetic plants was prepared screened against IDE by using various

Language: Английский

Citations

0