Integrin αvβ3-Targeted Therapeutic Strategies in Pancreatic Cancers DOI Creative Commons

Zi-Lin Li,

Ya‐Jung Shih,

Chung‐Che Tsai

et al.

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Pancreatic cancer is a significant health concern, primarily due to challenges in early diagnosis and limited treatment options. The increasing incidence of pancreatic cancers the lack effective chemotherapy underscore need for detection efficient therapy. cell surface integrin αvβ3 overexpresses most newly growing endothelial cells crucial growth metastasis. Novel nanotechnologies have been developed target its functions detective therapeutic purposes. This chapter details importance target, αvβ3, cancer’s development, proliferation, Theranostics, new strategy combined with diagnostics therapeutics, can help monitoring response. These cutting-edge technologies enable simultaneous through imaging targeted delivery therapeutics cells. Nanocarriers, such as liposomes PLGA, be used theranostics provide comprehensive approach potentially revolutionizing cancer. potential nano-drugs, either standalone treatments or theranostics, will explored. Combined currently available anticancer drugs, target-specific nano-delivery system personalized approach, where drug’s dosage duration adjusted based on patient’s elucidation targeting anti-vascular effects medicine introduce strategic therapy cancers.

Language: Английский

Integrin αvβ3-Targeted Therapeutic Strategies in Pancreatic Cancers DOI Creative Commons

Zi-Lin Li,

Ya‐Jung Shih,

Chung‐Che Tsai

et al.

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Pancreatic cancer is a significant health concern, primarily due to challenges in early diagnosis and limited treatment options. The increasing incidence of pancreatic cancers the lack effective chemotherapy underscore need for detection efficient therapy. cell surface integrin αvβ3 overexpresses most newly growing endothelial cells crucial growth metastasis. Novel nanotechnologies have been developed target its functions detective therapeutic purposes. This chapter details importance target, αvβ3, cancer’s development, proliferation, Theranostics, new strategy combined with diagnostics therapeutics, can help monitoring response. These cutting-edge technologies enable simultaneous through imaging targeted delivery therapeutics cells. Nanocarriers, such as liposomes PLGA, be used theranostics provide comprehensive approach potentially revolutionizing cancer. potential nano-drugs, either standalone treatments or theranostics, will explored. Combined currently available anticancer drugs, target-specific nano-delivery system personalized approach, where drug’s dosage duration adjusted based on patient’s elucidation targeting anti-vascular effects medicine introduce strategic therapy cancers.

Language: Английский

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