Associations between indicators of lipid and glucose metabolism and hypothyroidism

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 18, 2025

Language: Английский

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Associations between preoperative thyroid parameters, aggressive clinicopathological features and risk of recurrence in differentiated thyroid cancer

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: April 12, 2025

The study aimed (1) to investigate the association between aggressive clinicopathological characteristics and American Thyroid Association (ATA) recurrence risk classification in differentiated thyroid cancer (DTC) patients, (2) prognostic value of preoperative parameters. A total 3833 patients histologically confirmed DTC were recruited. Preoperative clinical postoperative pathologic data retrospectively collected. Participants stratified into low intermediate-to-high groups based on ATA stratification system. cohort had a mean age 48.87 ± 8.08 years, 1,465 (76.82%) female. Male (OR = 1.37, p .024), aged 52 years older 2.01, < .001), larger tumor size 3.71, 0.011), nerve invasion 6.69, .004), margin involvement 5.46, multifocality bilaterality 3.95, .001) identified as factors for higher classification, addition established such lymph node metastasis angioinvasion, after adjusting potential confounding variables. Higher levels free triiodothyronine (FT3), FT3 thyroxine (FT3/FT4), lower feedback quantile-based index (TFQI) associated with classification. comprehensive predictive model incorporating these variables demonstrated excellent discrimination (AUC 0.836). Furthermore, FT3/FT4 TFQI metastases angioinvasion. Factors male sex, age, multifocality, bilaterality, involvement, invasion, size, parameters serve complementary predictors DTC, conventional factors. These insights contribute more nuanced understanding optimization current methodologies.

Language: Английский

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High Prevalence of CKM Syndrome in the US and Chinese Population with MASLD

Published: Jan. 1, 2025

Language: Английский

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Pituitary-Thyroid Hormones and Related Indices in Euthyroid Type 2 Diabetes: Association With Thyroid Nodules

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2025, Volume and Issue: Volume 18, P. 627 - 636

Published: Feb. 1, 2025

Diabetes is an independent risk factor for thyroid nodules (TNs), however, the influencing factors of TNs have not been fully clarified under condition diabetes. Previous studies shown a connection between pituitary-thyroid hormone (TH) functions and in different populations. However, potential link euthyroid patients with diabetes unclear. We aimed to explore correlates type 2 (T2D) patients. This cross-sectional study included 1965 adults T2D. Clinical biochemical data, including TH relevant covariates were collected. evaluated using ultrasound. Univariate multivariate logistic regression analyses performed identify associated TNs, stratified by sex. The overall prevalence was 51.9%. higher females. Stratified sex, results from univariate further showed that free triiodothyronine (FT3) (OR: 1.381; 95% CI: 1.066-1.790) thyroid-stimulating index (TSHI) 0.740; 0.584-0.937) independently correlated only females, while no TH-related indicators entered model males. relationship related indices exhibited sex differences. Specifically, FT3 TSHI These findings underscore importance evaluating early monitoring management particularly female T2D

Language: Английский

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Association between thyroid function and acute mountain sickness upon rapid ascent to 3650 m in euthyroid lowlanders in China

Experimental Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract Acute mountain sickness (AMS) is a major health issue for lowlanders when they ascend rapidly to altitudes above 2500 m. Thyroid hormones are essential adaptive responses the hypoxic environment of high altitude. However, there limited evidence regarding association between thyroid function and prevalence AMS. This study included 70 healthy euthyroid Chinese who ascended from Beijing (44 m sea level) Lhasa (3650 by aircraft (flight time, approximately 5 h). The dataset was divided into training set (80%) validation (20%) development prediction model. hormones, demographic data blood biochemical were measured in week before ascent. subjects an AMS group non‐AMS based on 2018 Lake Louise Mountain Sickness Scale score. hormone sensitivity indices compared groups. Multivariable logistic regression analysis revealed that higher baseline total triiodothyronine (TT3) level (odds ratio (OR) 2.474, 95% confidence interval (CI) 1.083–5.653) free triiodothyronine/free thyroxine (FT3/FT4) (OR 3.427; CI 1.266–9.280) independent risk factors receiver‐operating characteristic calibration curves showed model had good predictive ability consistency both sets. In China, with TT3 or FT3/FT4 more susceptible after exposure altitudes.

Language: Английский

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Sex- and age-specific associations of serum essential elements with diabetes among the Chinese adults: a community-based cross-sectional study

Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 21(1)

Published: July 9, 2024

Abstract Background Although several studies have found the relationship between essential elements and diabetes, about association of with diabetes diagnosed according to an oral glucose tolerance test (OGTT) glycated hemoglobin (HbA1c) in a sex- age-specific manner were limited. To investigate linear nonlinear five including iron (Fe), copper (Cu), Zinc (Zn), magnesium (Mg), calcium (Ca) fasting plasma (FPG), 2-h postprandial (PPG), HbA1c evaluate heterogeneities these relationships. Methods A total 8392 community-dwelling adults recruited complete questionnaire undergo checkups anthropometric parameters serum levels metals (Fe, Cu, Zn, Mg, Ca). The multivariable logistic regression, restricted cubic spline (RCS) analysis, subgroup analysis applied find associations prevalence as well FPG, PPG, HbA1c. Results In regression Cu was positively associated while Mg significantly inversely correlated HbA1c, (all P < 0.001). RCS non-linear ( 0.001) found. stronger positive for interaction = 0.027) PPG 0.002) younger women. Conclusions These findings may lead more appropriate approaches supplementation people different ages sexes. However, prospective cohort experimental are needed probe possible mechanism diabetes.

Language: Английский

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Impaired Sensitivity to Thyroid Hormones is Associated with Central Obesity in Euthyroid Type 2 Diabetes Mellitus Patients with Overweight and Obesity

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2024, Volume and Issue: Volume 17, P. 3379 - 3396

Published: Sept. 1, 2024

Thyroid hormone levels are associated with the distribution of body components in humans.

Language: Английский

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Effects of thyroid hormones modify the association between pre-pregnancy obesity and GDM: evidence from a mediation analysis

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 13, 2024

Conflicting associations have been noted between thyroid function and gestational diabetes mellitus (GDM), with indications that pre-pregnancy BMI might influence these relationships. This study aims to examine the effect of hormone indices their mediation role on risk GDM.

Language: Английский

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Sex-specific associations between the developmental alterations in the pituitary-thyroid hormone axis and thyroid nodules in Chinese euthyroid adults: a community-based cross−sectional study

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: May 10, 2024

Background Previous studies have revealed the sex-specific features of pituitary–thyroid hormone (TH) actions and prevalence thyroid nodules (TNs) in children adolescents. However, it was unclear adults. We aimed to investigate pituitary–TH women men at different ages, associations thyrotropin (TSH), THs, central sensitivity THs indices including feedback quantile-based index by FT4 (TFQI ) FT3(TFQI FT3 with TNs Chinese euthyroid Methods 8771 adults from communities China were involved. Demographic, behavioral, anthropometric data gathered through questionnaires. Ultrasound performed evaluate TNs. TSH levels measured. The multivariable logistic regression ordinal conducted. Results TFQI among both genders, except aged 43 59 years, where increased slightly. Additionally, there an age-related decline ages &lt; 50 53, respectively, but a marked increase after that. Lower significantly associated higher lower odds having fewer using multiple as base category (both P for trend 0.05). 0.05), men. Both women. relationships between or number not found. Conclusions trends TSH, , sex-dependent. negatively present results may lead better understanding development pituitary-TH axis formation

Language: Английский

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Central and Peripheral Sensitivity to Thyroid Hormones Correlate to Metabolically Obesity Phenotypes in Chinese Euthyroid Adults: A Cross‐Sectional Study

Diabetes/Metabolism Research and Reviews, Journal Year: 2024, Volume and Issue: 40(8)

Published: Nov. 1, 2024

Thyroid hormones impact lipid metabolism and glucose homoeostasis through both central peripheral regulation; however, little research has delved into the association between thyroid hormone sensitivity metabolically obese phenotypes. We aimed to investigate correlation indices of phenotypes in euthyroid Chinese adults.

Language: Английский

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