The potential application of electrical stimulation in tendon repair: a review

Med-X, Journal Year: 2025, Volume and Issue: 3(1)

Published: March 4, 2025

Language: Английский

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Insulin-like growth factor-1 (IGF-1) empowering tendon regenerative therapies

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 27, 2025

Tendon injury is one of the most common musculoskeletal disorders that severely affect patients’ daily lives. Unfortunately, naturally healed tendons exhibit poor quality, as they have very limited regenerative ability. Recently, therapeutic strategies involving administration growth factors been advocated to enhance tendon healing. Growth are peptide-signaling molecules elicit biological functions such cell proliferation, migration, and differentiation by acting through a complex organization surface receptors activating intracellular signaling pathways. Insulin-like factor-1(IGF-1) represents factor has shown promising effects for enhancing healing in vitro animal models. However, it disappointing IGF-1 not play significant role promoting clinical trials, which could reflect our understanding molecular mechanisms involved Therefore, this review, we summarized roles Nevertheless, much work still needed optimize its effectiveness.

Language: Английский

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Histopathology Findings of Low‐Level Laser Therapy Effectiveness on Achilles Tendon Repair in Rabbit Model

Veterinary Medicine and Science, Journal Year: 2025, Volume and Issue: 11(3)

Published: April 11, 2025

ABSTRACT Background Low‐level laser therapy (LLLT) has been utilized to treat tendinitis and various other musculoskeletal conditions. The current study assessed the impact of LLLT (650 750 nm) on tendon repair in rabbits. Materials methods Fifteen 2‐year‐old male New Zealand White rabbits were divided into three groups: control, 650 nm therapy. After applying Achilles tendon‐destructive surgery their right legs, underwent LLLT, was using histopathology immunohistochemistry (IHC) findings. All data analysed SPSS version 21, considering a significant level <0.05. Results study's histopathological immunohistochemical analysis revealed that at significantly improved healing compared control group ( p < 0.05). treated groups exhibited better organized fibres with reduced discontinuity, collagen fibre waviness, inflammatory response Both wavelengths showed similar results no differences between them > 0.05), but both notably than reducing inflammation, enhancing structure, lowering levels type I (Col‐I); III (Col‐III); transformer growth factor beta (TGF‐β); galectin‐3 (galectin‐3); VGF nerve inducible; vascular endothelial (VEGF), indicating more effective process LLLT. Conclusion Due our findings, effectively structural integrity, enhanced organization for

Language: Английский

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Distal Triceps Tendon Rupture—First Retrospective Study in Central Europe

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(24), P. 7792 - 7792

Published: Dec. 20, 2024

Background: This retrospective study is the only one in last 10 years from central Europe and provides a current picture of prevalence, new diagnostic modalities, methods surgical treatment, also offers insights into post-operative care. Triceps tendon rupture least reported among all injuries literature. In general, effective treatments for are lacking because understanding biology lags behind that other components musculoskeletal system. Tendon tissue has low number cells growth hormones thus lack natural healing ability. Understanding links between mechanical biological parameters involved development, homeostasis, repair prerequisite identification chronic acute injuries. Methods: The authors statistically evaluated set patients with this diagnosis largest University Hospital Slovakia over years. Results: Between 2014 2023, 23 distal triceps ruptures (DTTR) were treated at Hospital. some not single patient underwent surgery, reinforcing idea DTTR may be either rare or underdiagnosed. incidence our region 0.46 cases per 100,000 inhabitants. average age was 57.7 years, male predominance 90%. Less than half (43.5%) intervention, median time injury to surgery less days. rapid timeline indicates high standard medical care, given semi-elective nature need MRI (Magnetic Resonance Imaging) confirmation exceeding 50% fibers before proceeding surgery. three techniques employed approximately equal proportions. Conclusions: suggests none currently preferred, choice technique largely determined by perioperative findings surgeon's discretion. Post-operative complications minimal, experiencing any issues after

Language: Английский

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Electrical Stimulation Therapy – Dedicated to the Perfect Plastic Repair

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Tissue repair and reconstruction are a clinical difficulty. Bioelectricity has been identified as critical factor in supporting tissue cell viability during the process, presenting substantial potential for application. This review delves into various sources of electrical stimulation identifies appropriate electrode materials use. It also highlights biological mechanisms at both subcellular cellular levels, elucidating how these interactions facilitate regeneration processes across different organs. Moreover, specific outlined, detailing their impact on activity. The future development trends projected from two perspectives: optimization equipment performance fulfillment demands, focusing feasibility, safety, cost-effectiveness technologies.

Language: Английский

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