Mutual Influence Between Allergic Rhinitis and Sleep: Factors, Mechanisms, and interventions—A Narrative Review DOI Creative Commons

Ting Yang,

Hanrui Wang, Yakui Mou

et al.

Nature and Science of Sleep, Journal Year: 2024, Volume and Issue: Volume 16, P. 1451 - 1467

Published: Sept. 1, 2024

Patients with allergic rhinitis (AR) have a high incidence of sleep disorders, such as insomnia, which can easily exacerbate nasal symptoms. The aggravation symptoms further promotes the deterioration forming vicious cycle. Severe cases may even trigger psychological and neurological issues, anxiety, depression, cognitive impairment, causing significant distress to patients, making clinical diagnosis treatment difficult, increasing costs. Furthermore, satisfactory therapeutics remain lacking. As pathogenesis AR-associated disorders is not clear research still insufficient, paying attention understanding AR-related crucial in practice. Multiple studies shown that most issues current on AR are analyzing relationship between searching for influencing factors, investigating potential targets treatment. This review aimed identify summarize results relevant using "AR" "sleep disorders" search terms. In addition, we evaluated correlation examined their interaction mechanisms, offering foundation additional screening diagnostic biomarkers therapeutic targets.

Language: Английский

Lipopolysaccharide-binding protein levels, obstructive sleep apnea, and depression: A cross-sectional study of adults DOI
Oliwia Gawlik-Kotelnicka, Agata Gabryelska, Marcin Sochal

et al.

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149575 - 149575

Published: March 1, 2025

Language: Английский

Citations

0
Gut microbiota contributes to obstructive sleep apnea-induced hypertension by gut-heart axis in mice DOI Creative Commons
Xiaotong Zhang,

Yanran Yin,

Yongjun Chen

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114667 - 114667

Published: April 16, 2025

The gut microbiome has been closely linked to obstructive sleep apnea (OSA)-associated hypertension (HTN). However, its precise role in the pathogenesis of OSA-induced HTN remains unclear. To clarify causal relationship between dysbiosis and OSA-related HTN, C57BL6J mice were randomly assigned four groups. Each group underwent fecal microbiota transplantation from healthy individuals (control), OSA patients (OSA group), with pre-hypertension (OSA-pHTN or (OSA-HTN group). pro-hypertensive effects verified, composition function compared using 16S rDNA gene sequencing. Additionally, microbiota-related lipopolysaccharide (LPS)/ Toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-κB) pathway aortic tissues was investigated. Fecal induced increased systolic blood pressure injury OSA, OSA-pHTN OSA-HTN groups, whereas no significant observed control group. These three groups exhibited impaired intestinal barrier as evidenced by a reduction Akkermansia decreased expression zonula occludens-1 Occludin proteins. In addition, LPS, TLR4 phosphorylated NF-κB tissue immunofluorescence showed upregulation endothelial cells controls. This study demonstrates mediated through gut-derived LPS/TLR4/NF-κB pathway. findings may guide development therapeutic strategies focused on restoring homeostasis.

Language: Английский

Citations

0
Circadian Regulation in Diurnal Mammals: Neural Mechanisms and Implications in Translational Research DOI Creative Commons
Yiran Jiang,

Jiaming Shi,

Jun Tai

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 958 - 958

Published: Nov. 22, 2024

Diurnal and nocturnal mammals have evolved unique behavioral physiological adaptations to optimize survival for their day- or night-active lifestyle. The mechanisms underlying the opposite activity patterns are not fully understood but likely involve interplay between circadian time-keeping system various arousal- sleep-promoting factors, e.g., light melatonin. Although systems two chronotypes share considerable similarities, phase relationships principal subordinate oscillators chronotype-specific. While promotes arousal wakefulness in diurnal species like us, it induces sleep ones. Similarly, melatonin, hormone of darkness, is commonly used as a hypnotic humans secreted active animals. Thus, difference more complex than simple reversal, neurological processes during day equivalent that ones at night. Such chronotype differences could present significant translational gap when applying research findings obtained from rodents humans. potential advantages models being discussed few sleep-related conditions including familial natural short (FNSS), obstructive apnea (OSA), Smith-Magenis syndrome (SMS). Considering chronotype, model will be adequate revealing physiology physiopathology pertaining human health disease, especially which rhythm disruption, altered photic response, melatonin secretion involved. We hope recent advances gene editing promote greater utility basic research.

Language: Английский

Citations

2
Mutual Influence Between Allergic Rhinitis and Sleep: Factors, Mechanisms, and interventions—A Narrative Review DOI Creative Commons

Ting Yang,

Hanrui Wang, Yakui Mou

et al.

Nature and Science of Sleep, Journal Year: 2024, Volume and Issue: Volume 16, P. 1451 - 1467

Published: Sept. 1, 2024

Patients with allergic rhinitis (AR) have a high incidence of sleep disorders, such as insomnia, which can easily exacerbate nasal symptoms. The aggravation symptoms further promotes the deterioration forming vicious cycle. Severe cases may even trigger psychological and neurological issues, anxiety, depression, cognitive impairment, causing significant distress to patients, making clinical diagnosis treatment difficult, increasing costs. Furthermore, satisfactory therapeutics remain lacking. As pathogenesis AR-associated disorders is not clear research still insufficient, paying attention understanding AR-related crucial in practice. Multiple studies shown that most issues current on AR are analyzing relationship between searching for influencing factors, investigating potential targets treatment. This review aimed identify summarize results relevant using "AR" "sleep disorders" search terms. In addition, we evaluated correlation examined their interaction mechanisms, offering foundation additional screening diagnostic biomarkers therapeutic targets.

Language: Английский

Citations

0