Regulation of Protein Transport in Functionalized PET Nanopores

The Journal of Physical Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Facilitated translocation is a critical mechanism for transporting substances in biological systems, where molecular and ionic species move across the membrane with help of specific transmembrane protein ion channels. In this work, we systematically examined transport three poly(ethylene terephthalate) (PET) nanopores modified different types surface functions (hydroxyl, phenyl, amine). We found that event signature as well kinetics thermodynamics movement PET nanopore varied significantly change function pore. addition to electrophoretic effect, other factors such diffusion, electro-osmotic selectivity channel, affinity strength between functional group also play significant roles transport. Although properly functionalized individual can be used stochastic elements rapid differentiation characterization, enhanced resolution accuracy could accomplished by employing an array having inner groups characterize proteins based on their collective responses. Given important living organisms applications biomarkers early disease diagnosis prognosis, pattern-recognition solid-state nanopore-sensing strategy detection characterization developed work may find useful various fields.

Language: Английский

Correlates of Markedly Elevated C-reactive Protein >200 mg/L and Its Prognostic Role in Intensive Care Unit Admission and Mortality: A Record-based Retrospective Study

Journal of Applied Sciences and Clinical Practice, Journal Year: 2025, Volume and Issue: 6(1), P. 32 - 38

Published: Jan. 1, 2025

Abstract Background: There is a dearth of research on markedly elevated C-reactive protein (CRP) levels, especially in the Indian subcontinent. Existing studies focus specific disease states and low CRP elevations. With high costs intensive care unit (ICU) management hospital mortality India, it essential for primary physicians to examine elevation early identification high-risk patients prompt referral decisions. Aim: The aim study was ascertain correlates prognostic value >200 mg/L terms ICU admission mortality. Materials Methods: This retrospective conducted at 1500-bedded tertiary-care teaching hospital. Adult with levels from January 1, 2018, December 31, 2019 were identified electronic database their medical records reviewed patient characteristics, clinical diagnoses, outcomes. data statistically analyzed by RStudio Desktop Version 2023.03.0 + 386. Results: A total 556 adult included this study. most common cause infection 230 (41.4%), followed inflammation 80 (14.4%). Patients level >400 had significantly higher chances getting admitted (Adjusted odds ratio = 12.39, P 0.001) more risk hazard 7.268, < compared 201–300 mg/L. Conclusions: has presence as predominant Present findings underscore necessity close monitoring vigilant prognosis assessment exceeding 400 mg/L, they have increased rates, necessitating urgent settings.

Language: Английский