Results and problems in cell differentiation, Journal Year: 2024, Volume and Issue: unknown, P. 475 - 520
Published: Jan. 1, 2024
Language: Английский
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 180, P. 18 - 45
Published: April 17, 2024
Bacterial extracellular vesicles (BEVs) are naturally occurring bioactive membrane-bound nanoparticles released by both gram-negative and gram-positive bacterial species, exhibiting a multifaceted role in mediating host-microbe interactions across various physiological conditions. Increasing evidence supports BEVs as essential mediators of cell-to-cell communicaiton, influencing pathogenicity, disease mechanisms, modulating the host immune response. However, extent to which these BEV-mediated actions can be leveraged predict onset, guide treatment strategies, determine clinical outcomes remains uncertain, particularly terms their translation potentials. This review briefly describes BEV biogenesis internalisation recipient cells summarises methods for isolation characterization, understanding composition cargo. Further, it discusses potential biofluid-associated biomarkers diseases, spanning cancer non-cancerous Following this, we outline ongoing human trials using vaccine development. In addition diagnostics, this explores emerging research natural or engineered smart nanomaterials applications anti-cancer therapy bone regeneration. discussion extends key factors unlocking BEVs, such standardization characterisation, well other hurdles translating findings setting. We propose that addressing through collaborative efforts well-designed holds fully harnessing BEVs. As field advances, suggests BEV-based nanomedicine has revolutionize management, paving way innovative diagnosis, therapeutics, personalized medicine approaches. STATEMENT OF SIGNIFICANCE: Extracellular (EVs) from bacteria serve multifunctional biomaterials fields biomedicine, bioengineering, biomaterials. majority current studies focus on host-derived EVs, leaving gap comprehensive bacteria-derived EVs (BEVs). Although offer an attractive option drug delivery systems, unique nanostructure easy-to-modify functions make them method diagnosis Our work among pioneering investigating nanobiomaterials plays crucial development diseases therapeutic interventions.
Language: Английский
Citations
26
Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 182, P. 373 - 390
Published: Jan. 17, 2025
Language: Английский
Citations
0
Schizophrenia, Journal Year: 2025, Volume and Issue: 11(1)
Published: Feb. 12, 2025
Abstract The diagnosis of schizophrenia (SCZ) primarily relies on clinical history and mental status assessments by trained professionals. There has been a search for biomarkers to facilitate laboratory diagnosis. Since extracellular vesicles (EVs) communicate with brain cells can easily cross blood-brain barrier, there is increased interest among experts explore them as potential molecular signals disease detection. A scoping review was conducted provide comprehensive summary the existing literature identify differentially expressed in EVs isolated from SCZ patients. methodological framework outline provided Arksey O’Malley employed conduct this review. systematic using string across four databases, ultimately leading selection 24 relevant studies. Over 1122 biomolecules were identified extracted biological fluids tissues that be categorized RNAs, proteins, metabolites. Among them, 83 validated signals, which included metabolites, circRNAs, lncRNAs, miRNAs, proteins. These found affect cellular receptors intracellular pathways, neurotransmitters, mitochondrial functions, immune-related metabolic could serve
Language: Английский
Citations
0
Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Citations
0
Results and problems in cell differentiation, Journal Year: 2024, Volume and Issue: unknown, P. 475 - 520
Published: Jan. 1, 2024
Language: Английский
Citations
1