Comparative analysis of central versus peripheral visual field test grids in the diagnosis of glaucoma DOI Creative Commons

Christian Kirou,

Ali Khazandi,

Jose J. Estevez

et al.

Clinical and Experimental Optometry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Oct. 7, 2024

Accumulating evidence has recognised central visual field defects (CVFDs) as a common feature of glaucoma. Current glaucoma screening guidelines include peripherally biased perimetry (24–2 protocols), but test grids exist to the integrity (10–2 protocols). However, added benefit incorporating assessments alongside peripheral-biased testing remains unclear. This scoping review aimed compare diagnostic accuracy versus peripheral tests. A systematic search six databases yielded relevant studies among subjects. These were synthesised narratively, focusing on performance indicators such area under curve, sensitivity, specificity, agreement, and structure-function concordance. Of 1875 screened, 16 included in review. The comparative analyses demonstrated similar when comparing ability 24–2 10–2 detect or CVFDs. When utilising mean deviation, curve ranged between 0.81–0.87 0.74–0.84 for 10–2, whilst pattern standard deviation was 0.95 0.82, respectively. showed sensitivities reaching 0.75 0.60 with specificities high both grids. Across all disease stages, CVFDs detected up 88% agreement functional damage 10–2. greatest combining optical coherence tomography (88.7%). indicates that protocols offer comparable glaucoma, including detecting While targeted macula could provide additional value certain contexts, inconclusive. Further longitudinal studies, tomography, are necessary confirm these findings consider routine inclusion CVFD clinical practice.

Language: Английский

Predicting visual field global and local parameters from OCT measurements using explainable machine learning DOI Creative Commons
Md. Mahmudul Hasan, Jack Phu, Henrietta Wang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 16, 2025

Abstract Glaucoma is characterised by progressive vision loss due to retinal ganglion cell deterioration, leading gradual visual field (VF) impairment. The standard VF test may be impractical in some cases, where optical coherence tomography (OCT) can offer predictive insights into for multimodal diagnoses. However, predicting measures from OCT data remains challenging. To address this, five regression models were developed predict OCT, Shapley Additive exPlanations (SHAP) analysis was performed interpretability, and a clinical software tool called Predictor developed. evaluate the models, total of 268 glaucomatous eyes (86 early, 72 moderate, 110 advanced) 226 normal included. machine learning outperformed recent OCT-based prediction deep studies, with correlation coefficients 0.76, 0.80 0.76 mean deviation, index pattern respectively. Introducing pointwise normalisation step-size concept, absolute error 2.51 dB obtained sensitivity prediction, grayscale model yielded structural similarity 77%. SHAP-based provided critical most relevant features glaucoma diagnosis, showing promise assisting eye care practitioners through an explainable AI tool.

Language: Английский

Citations

4
Visual field testing in glaucoma using the Swedish Interactive Threshold Algorithm DOI Creative Commons
Jeremy Tan, Jithin Yohannan, Pradeep Y. Ramulu

et al.

Survey of Ophthalmology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

6
Glaucoma: challenges and opportunities DOI Open Access
Michael Kalloniatis, Bang V. Bui, Jack Phu

et al.

Clinical and Experimental Optometry, Journal Year: 2024, Volume and Issue: 107(2), P. 107 - 109

Published: Feb. 17, 2024

Language: Английский

Citations

2
The effect of macular visual field test density on central structure-function concordance in glaucoma DOI Creative Commons
Daniel Rafla, Michael Kalloniatis, Jack Phu

et al.

Clinical and Experimental Optometry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: March 14, 2024

Clinical relevance Central visual field (VF) testing often requires focussed high-density test grids. The critical number of locations for maximising structure-function concordance in the macula is not known.

Language: Английский

Citations

2
Standard automated perimetry for glaucoma and diseases of the retina and visual pathways: current and future perspectives DOI Creative Commons
Jack Phu, Sieu K. Khuu, Lisa Nivison‐Smith

et al.

Progress in Retinal and Eye Research, Journal Year: 2024, Volume and Issue: unknown, P. 101307 - 101307

Published: Oct. 1, 2024

Language: Английский

Citations

1
Comparative analysis of central versus peripheral visual field test grids in the diagnosis of glaucoma DOI Creative Commons

Christian Kirou,

Ali Khazandi,

Jose J. Estevez

et al.

Clinical and Experimental Optometry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Oct. 7, 2024

Accumulating evidence has recognised central visual field defects (CVFDs) as a common feature of glaucoma. Current glaucoma screening guidelines include peripherally biased perimetry (24–2 protocols), but test grids exist to the integrity (10–2 protocols). However, added benefit incorporating assessments alongside peripheral-biased testing remains unclear. This scoping review aimed compare diagnostic accuracy versus peripheral tests. A systematic search six databases yielded relevant studies among subjects. These were synthesised narratively, focusing on performance indicators such area under curve, sensitivity, specificity, agreement, and structure-function concordance. Of 1875 screened, 16 included in review. The comparative analyses demonstrated similar when comparing ability 24–2 10–2 detect or CVFDs. When utilising mean deviation, curve ranged between 0.81–0.87 0.74–0.84 for 10–2, whilst pattern standard deviation was 0.95 0.82, respectively. showed sensitivities reaching 0.75 0.60 with specificities high both grids. Across all disease stages, CVFDs detected up 88% agreement functional damage 10–2. greatest combining optical coherence tomography (88.7%). indicates that protocols offer comparable glaucoma, including detecting While targeted macula could provide additional value certain contexts, inconclusive. Further longitudinal studies, tomography, are necessary confirm these findings consider routine inclusion CVFD clinical practice.

Language: Английский

Citations

0