Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 2, 2024
Abstract
Background
Compared
to
the
conventional
anion
gap,
albumin-corrected
gap
(ACAG)
offers
a
more
precise
measure
of
acid-base
imbalance
in
patients
than,
providing
superior
prognostic
insight.
However,
relevance
ACAG
individuals
atrial
fibrillation
(AF)
remains
insufficiently
explored.
This
research
seeks
evaluate
correlation
between
levels
and
mortality
risk
with
AF.
Methods
We
identified
diagnosed
AF
from
Medical
Information
Mart
for
Intensive
Care
(MIMIC)-IV
database.
Participants
were
categorized
into
quartiles
accordance
their
levels.
The
outcomes
included
30
days
365
all-cause
mortality.
Cumulative
survival
across
was
assessed
using
Kaplan–Meier
curves.
applied
Cox
regression
restricted
cubic
spline
analyses
prognosis.
Subgroup
interaction
assessments
confirm
robustness
findings.
Results
A
total
2920
(54.93%
male)
incorporated
analysis.
365-day
22.91%
39.21%,
respectively.
curves
demonstrated
that
elevated
significantly
linked
increased
(log-rank
P
<
0.001).
In
multivariate
proportional
hazards
analyses,
independently
predicted
at
(adjusted
hazard
ratio
[aHR],
1.04;
95%
CI,
1.02–1.05;
P
0.01)
(aHR,
1.03;
after
adjusting
potential
confounders.
positive
relationship
rising
risk,
as
showed
by
revealed
no
significant
interactions
(all
P-values
>
0.05).
Conclusions
AF,
higher
are
related
greater
days.
These
results
show
value
indicator
patient
stratification.
Incorporating
clinical
decision-making
could
support
improved
therapeutic
strategies
enhance
outcomes.
Therapeutic Advances in Respiratory Disease,
Journal Year:
2025,
Volume and Issue:
19
Published: Jan. 1, 2025
The
relationship
between
albumin-corrected
anion
gap
(ACAG)
and
in-hospital
mortality
in
critically
ill
patients
with
COPD
remains
unclear.
This
study
investigated
the
association
ACAG
levels
risk
of
COPD.
A
retrospective
cohort
study.
uses
data
from
Medical
Information
Mart
for
Intensive
Care
(MIMIC-IV)
database.
receiver
operating
characteristic
(ROC)
curve
was
used
to
determine
optimal
threshold
ACAG,
participants
were
divided
into
two
categories
based
on
this
threshold.
primary
outcome
mortality.
We
employed
univariable
multivariable
logistic
regression
analyses
Kaplan-Meier
(KM)
survival
curves
assess
Moreover,
subgroup
conducted.
total
2121
(54.7%
male)
enrolled
rate
18.9%.
In
elevated
levels,
significantly
higher
than
those
lower
(27.7%
vs
11.3%,
p
<
0.001).
Multivariate
analysis
indicated
that
even
after
mitigating
potential
confounders,
high
group
had
greater
odds
across
all
models
(Model
I:
OR
=
3.000,
95%
CI:
2.383-3.777,
0.001;
Model
II:
3.021,
2.397-3.808,
III:
1.916,
1.458-2.519,
Patients
have
more
twice
compared
(hazard
ratio
(HR):
2.1277,
1.7490-2.5884).
demonstrates
are
strongly
associated
an
increased
patients,
suggesting
could
serve
as
a
predictor
adverse
outcomes
patient
population.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Oct. 29, 2024
The
relationship
between
albumin-corrected
anion
gap
(ACAG)
and
severe
disorder
of
consciousness
(SDOC),
in-hospital
mortality,
long-term
mortality
in
patients
with
ischemic
stroke
(IS)
remains
unclear.
This
study
investigates
the
association
ACAG
SDOC
other
outcomes
IS
using
data
from
MIMIC-IV
database.
A
total
2,379
were
included,
a
demographic
breakdown
showing
51%
male
an
incidence
16.4%.
Analysis
through
Cox
proportional
hazards
models
indicated
that
is
significantly
associated
risks
both
mortality.
Additionally,
restricted
cubic
spline(RCS)
analysis
suggested
nearly
linear
increasing
levels
SDOC.
Kaplan-Meier
curves
demonstrated
significant
differences
rates
SDOC,
across
varying
levels.
findings
suggest
serves
as
independent
predictor
for
patients.
Nonetheless,
further
prospective
studies
are
needed
to
confirm
these
causal
relationships.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 8, 2025
This
study
aims
to
explore
the
relationship
between
albumin-corrected
anion
gap
(ACAG)
and
short-
long-term
all-cause
mortality
(ACM)
in
patients
with
acute
pancreatitis
(AP)
managed
intensive
care
unit
(ICU).
We
conducted
a
retrospective
analysis
utilizing
data
extracted
from
Medical
Information
Mart
for
Intensive
Care-IV
(MIMIC-IV)
database.
sought
investigate
correlation
ACAG
ACM
among
diagnosed
AP
across
various
disease
stages.
R
statistical
software
was
used
identify
optimal
thresholds
ACAG.
Kaplan-Meier
survival
curves
multivariate
Cox
proportional
hazards
regression
models
were
employed
assess
association
of
AP.
The
predictive
ability,
sensitivity,
specificity,
area
under
curve
(AUC)
investigated
using
receiver
operating
characteristic
analysis.
Subgroup
analyses
also
conducted.
A
cohort
comprising
605
participants
included
this
study.
ideal
threshold
identified
by
21.5.
modeling
revealed
that
there
an
independent
≥
21.5
at
3,
7,
10,
14,
28,
90,
180
days
1
year
before
after
adjustment
confounders.
Survival
demonstrated
had
lower
rates
year.
In
addition,
showed
superior
performance,
larger
AUC
than
gap,
albumin,
Systemic
Inflammatory
Response
Syndrome
score
Sequential
Organ
Failure
Assessment
no
significant
interaction
any
subgroups
Elevated
levels
found
be
associated
increased
AP,
may
predictor
different
BMC Cardiovascular Disorders,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 27, 2025
Compared
to
the
conventional
anion
gap,
albumin-corrected
gap
(ACAG)
offers
a
more
precise
measure
of
acid-base
imbalance,
providing
superior
prognostic
insight.
However,
relevance
ACAG
in
individuals
atrial
fibrillation
(AF)
remains
insufficiently
explored.
This
research
seeks
evaluate
correlation
between
levels
and
mortality
risk
with
AF.
We
identified
diagnosed
AF
from
Medical
Information
Mart
for
Intensive
Care
(MIMIC)-IV
database.
Participants
were
categorized
into
quartiles
based
on
their
levels.
The
outcomes
included
30
days
365
all-cause
mortality.
Kaplan-Meier
survival
curves
utilized
cumulative
across
quartiles.
applied
Cox
regression
restricted
cubic
spline
analyses
prognosis.
Subgroup
interaction
assessments
confirm
robustness
findings.
A
total
2920
patients
(54.93%
male)
incorporated
analysis,
1.61%
as
having
paroxysmal
30-day
365-day
rates
22.91%
39.21%,
respectively.
demonstrated
that
elevated
significantly
linked
increased
(log-rank
P
<
0.001).
In
multivariate
proportional
hazards
analyses,
independently
predicted
at
both
(adjusted
hazard
ratio
[aHR],
1.04;
95%
CI,
1.02-1.05;
0.01)
(aHR,
1.03;
after
adjusting
potential
confounders.
positive
relationship
rising
was
showed
by
analysis.
revealed
no
significant
interactions
(all
P-values
>
0.05).
AF,
higher
are
related
greater
days.
These
findings
suggest
may
serve
valuable
marker
patient
stratification.
Incorporating
clinical
decision-making
could
support
improved
therapeutic
strategies
enhance
outcomes.
Frontiers in Aging,
Journal Year:
2025,
Volume and Issue:
6
Published: Feb. 11, 2025
Objectives
This
study
aimed
to
investigate
the
relationship
between
albumin-corrected
anion
gap
(ACAG)
and
lumbar
spine
bone
mineral
density
(BMD)
in
a
diverse
population,
assessing
how
variations
ACAG
levels
correlate
with
changes
BMD
potential
implications
for
osteoporosis
risk.
Methods
A
cross-sectional
analysis
was
conducted
involving
3,057
participants
(1,555
males
1,502
females).
Participants
were
stratified
into
quartiles
based
on
baseline
levels.
Demographic
clinical
characteristics
analyzed,
including
age,
sex,
education
level,
body
mass
index
(BMI),
prevalence
of
diabetes
hypertension.
The
association
evaluated
using
multiple
regression
models,
generalized
additive
model
employed
identify
nonlinear
relationships.
Results
revealed
significant
negative
correlation
(
P
<
0.001).
For
each
1-unit
increase
ACAG,
decreased
β
coefficients
−0.004
−0.005
across
various
models.
Quartile
indicated
that
highest
quartile
(≥19.55)
experienced
most
substantial
reductions
(β
ranging
from
−0.034
−0.036,
Furthermore,
U-shaped
identified,
turning
point
at
an
value
22.15,
indicating
lower
associated
BMD,
while
higher
showed
positive
effect.
Subgroup
analyses
by
sex
demonstrated
consistent
findings,
associations
both
females.
Conclusion
findings
underscore
elevated
reduced
suggesting
may
serve
as
valuable
biomarker
identified
further
emphasizes
complexity
metabolic
influences
health.
These
results
warrant
investigation
mechanisms
underlying
ACAG’s
impact
its
role
prevention
strategies.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: May 4, 2025
Acute
ischemic
stroke
(AIS)
remains
a
major
cause
of
global
morbidity
and
mortality.
This
study
aimed
to
evaluate
the
role
albumin
corrected
anion
gap
(ACAG)
as
prognostic
marker
for
AIS
patients.
We
analyzed
data
from
1014
patients
in
MIMIC-IV
database,
stratifying
by
ACAG
levels.
Using
Cox
proportional
hazards
models,
restricted
cubic
splines,
Kaplan-Meier
survival
analysis,
we
assessed
relationship
between
both
30-day
365-day
Our
results
show
that
elevated
levels
are
significantly
associated
with
higher
mortality
rates
at
time
points.
The
hazard
ratios
were
1.07
(95%
CI
1.04-1.11,
P
<
0.001)
1.06
1.03-1.09,
0.001),
respectively.
Receiver
operating
characteristic
(ROC)
analysis
showed
area
under
curve
(AUC)
predicting
was
0.666
0.662,
Subgroup
revealed
significant
interactions
gender
sepsis
status.
A
nomogram
incorporating
other
key
variables
achieved
AUCs
0.748
0.765
mortality,
These
findings
indicate
is
an
independent
risk
factor
short-term
long-term
Its
incorporation
into
clinical
practice
may
enhance
ability
clinicians
identify
high-risk
early,
enabling
timely
targeted
interventions.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(15), P. e35199 - e35199
Published: July 26, 2024
Influenza
is
an
important
global
health
concern,
particularly
in
critically
ill
patients.
The
anion
gap,
a
marker
of
metabolic
acidosis,
associated
with
mortality
various
critical
illnesses.
However,
its
association
patients
influenza
remains
unclear.
This
study
investigated
the
between
gap
on
admission
and
28-day
influenza.
BMC Cardiovascular Disorders,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Oct. 23, 2024
The
relationship
between
serum
anion
gap
(AG)
and
28-day
mortality
in
critically
ill
patients
with
infective
endocarditis
is
currently
not
well
established.
This
study
aims
to
investigate
the
impact
of
AG
on
endocarditis.
A
retrospective
cohort
was
conducted
involving
449
participants
diagnosed
admitted
intensive
care
units
(ICU).
Vital
signs,
laboratory
parameters
comorbidity
were
collected
for
all
analyze
association
levels
mortality.
total
(IE)
included
study.
mean
age
57
years,
64%
male.
overall
rate
20%.
greater
admission
significantly
associated
increased
unadjusted
analysis
(hazard
ratio
[HR]
1.13;
95%
confidence
interval
[CI]
1.09–1.18;
p
<
0.001).
After
adjusting
confounders,
remained
significant
(adjusted
HR
1.07;
CI
1.02–1.13;
=
0.003).
When
converted
into
categorial
variables
(quartiles),
risk
greatest
Q4
group
higher
compared
that
lowest
Q1
(model
4:
2.62,
95%CI:
1.17–5.83,
0.019).
Subgroup
showed
consistent
results
across
different
groups.
independently
IE.
These
findings
suggest
can
serve
as
a
prognostic
marker
this
population,
aiding
stratification
guiding
clinical
management.
BMC Cardiovascular Disorders,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Dec. 20, 2024
The
associations
between
the
albumin-corrected
anion
gap
(ACAG)
and
all-cause
mortality
in
patients
with
congestive
heart
failure
intensive
care
unit
remain
uncertain.
This
study
aimed
to
investigate
this
unknown.
MIMIC-IV
(version
3.0)
database
was
used
analyze
critically
ill
failure.
Patients
were
grouped
into
tertiles
(T1-T3)
on
basis
of
ACAG.
association
ACAG
levels
1-year
assessed
using
Kaplan-Meier
survival
analyses,
multivariate
adjusted
Cox
regression
models,
restricted
cubic
spline
curves.
An
analysis
subgroups
performed
evaluate
ACAG's
prognostic
impact
across
diverse
populations.
Mediation
conducted
identify
elucidate
potential
causal
pathways
linking
mortality.
A
cohort
7787
analyzed.
On
curves,
regression,
curves
subgroup
analysis,
T2
(hazard
ratio
1.09,
95%
confidence
interval
1.02
~
1.16)
T3
1.25,
1.17
1.33)
individuals
presented
a
greater
risk
compared
T1
(p
for
linear
trend
<
0.001),
most
consistently
observed
relationship,
except
those
different
left
ventricular
ejection
fraction.
indicated
that
red
cell
distribution
width,
stage
acute
kidney
injury,
chloride
physiology
score
III
partially
mediated
relationship
mortality,
accounting
12.4%,
7.0%,
12.9%,
31.2%
mediating
effect,
respectively.
associated
higher
failure,
stronger
lower
fractions.
may
serve
as
an
indicator
high-risk
groups.
Not
applicable.
