Kidney-brain axis in the pathogenesis of cognitive impairment

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 200, P. 106626 - 106626

Published: Aug. 8, 2024

The kidney-brain axis is a bidirectional communication network connecting the kidneys and brain, potentially affected by inflammation, uremic toxin, vascular injury, neuronal degeneration, so on, leading to range of diseases. Numerous studies emphasize disruptions may contribute high morbidity neurological disorders, such as cognitive impairment (CI) in natural course chronic kidney disease (CKD). Although pathophysiology has not been fully elucidated, epidemiological data indicate that patients at all stages CKD have higher risk developing CI compared with general population. In contrast other reviews, we mentioned some commonly used medicines play pivotal role pathogenesis CI. Revealing interactions between damage brain function can reduce potential future This review will deeply explore characteristics, indicators, pathophysiological mechanisms CKD-related It provide theoretical basis for identifying progresses during ultimately prevents treats

Language: Английский

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IgA nephropathy is associated with Opisthorchis felineus liver fluke infection: Retrospective 5‐year analysis of human kidney samples

Tropical Medicine & International Health, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Infection with the fish-borne liver fluke Opisthorchis felineus, which is transmitted through consumption of raw or undercooked fish, results in serious damage humans. Currently, limited clinical and experimental data reveal kidney co-occurring chronic opisthorchiasis. We conducted a retrospective analysis autopsy samples over five-year period (n = 84). The aim study was to assess pathomorphological changes kidneys evaluate whether there an association between IgA nephropathy infection. Histological analysis, immunohistochemistry, statistical were performed. In this study, we demonstrated for first time that O. felineus infection humans associated tubular dystrophy, accumulation renal casts, glomerulosclerosis. hypertension increases also detected total antigen glomeruli infected people. Fisher's test showed significant nephropathy, as well Therefore, findings highlight importance recognising more than hepatobiliary disease emphasise need careful, personalised monitoring function individuals.

Language: Английский

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Features of interleukin-17 and interleukin-23 expression in patients with inflammatory bowel diseases

GASTROENTEROLOGY, Journal Year: 2025, Volume and Issue: 59(1), P. 44 - 49

Published: April 12, 2025

Background. Inflammatory bowel disease (IBD) is a serious medical and social problem, which leads to significant interest in the study of etiology, pathogenesis, development diagnostic therapeutic complexes. There growing evidence that interleukin (IL) 17 IL-23 are potent mediators inflammatory reactions various tissues, including intestine. In this regard, it important cytokine levels depending on activity intestinal inflammation severity IBD. The aim was determine features interleukins 23 expression patients with disease. Materials methods. We examined 80 IBD (63 ulcerative colitis (UC) Crohn’s (CD)) who were divided according course. control group consisted 10 healthy individuals. Serum IL-17 determined by enzyme-linked immunosorbent assay using Stat Fax 303 Plus analyzer (USA). Reagent kits from TECAN IBL International GmbH (Germany) used study. Results. concentration UC CD significantly higher, 11.4 (p < 0.05) 17.6 times 0.05), respectively, compared group. Its median level 1.5 higher than UC. increase participants (8.1-fold, p (7.5-fold, controls, but did not differ between nosologies. moderate severe No differences found varying (7.4-fold, (11.2-fold, controls. UC, Correlations endoscopic index (r = +0.347; 0.005) Mayo +0.295; 0.020). content 9.9 9.0 CD, without difference severity. 1.6 CD. Conclusions. patients. tended depended both pathologies confirmed established correlations 0.020) Quantification serum may be useful additional criterion for differential diag­nosis promising clinical marker determining

Language: Английский

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Inflammatory Bowel Diseases and Nephropathies: Exploring the Gut–Kidney Axis

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1541 - 1541

Published: Nov. 25, 2024

Inflammatory bowel disease (IBD) can extend beyond the gastrointestinal tract, affecting extraintestinal organs and significantly increasing morbidity mortality. Despite early studies revealing kidney involvement in nearly a quarter of patients with IBD, renal manifestations have been notably overlooked. Among these manifestations, nephrolithiasis, obstructive uropathy, fistula formation between urinary tract are most reported occurrences. Additionally, parenchymal including glomerulonephritis (GN), tubulointerstitial nephritis, amyloidosis, has documented. GN is particularly noteworthy, as significant proportion progress to end-stage (ESKD). Although long recognized potential manifestation (EIM) it often dismissed an anecdotal association. Recently, several highlighted clinical correlation suggesting pathogenic interplay involving gut inflammation, dysbiosis, intrinsic glomerular processes. Thus, our objective elucidate basis IBD-related nephropathies, specific focus on IgA nephropathy (IgAN) gut–kidney axis.

Language: Английский

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Identification of potential immune-related genes and infiltrations in temporomandibular joint osteoarthritis

Annals of Medicine and Surgery, Journal Year: 2024, Volume and Issue: 86(12), P. 7135 - 7146

Published: Oct. 22, 2024

Objective: The aim of this study was to investigate the potential inflammatory cytokines and chemokines markers for temporomandibular joint osteoarthritis (TMJOA) diagnosis using a bioinformatics analysis. Methods: differentially expressed genes mRNA (DEGs) transcripts lncRNA (DETs) were identified between TMJOA samples normal controls curated from GSE205389 by “DESeq. 2” R package. KEGG GO conducted package “ggplot2” “clusterProfiler”. A PPI network constructed identify hub STRING Cytoscape. co-expression check regulation function on protein-coding genes. Finally, immune cell infiltration analysis with CIBERSORTx confirmed xCells. Results: authors 171 DEGs DETs, which closely related response, T-cell activation, cytokine-cytokine-receptor interaction, muscle system process. screened top 10 genes, including IL6, IL1B, IL10, CCL2, CCL5, CXCL1, CXCL10, ICAM1, CSF1 MMP1 . Additionally, showed that CD8 + T cells, M1 macrophage B cells increased in samples. demonstrated mainly enriched muscle-related pathways. Conclusions: found system-related pathways as well played significant role development. could be crucial early-stage personalized treatment strategies.

Language: Английский

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