Remnant cholesterol has a nonlinear association with non-alcoholic fatty liver disease: A secondary retrospective cohort study in non-obese Chinese adults DOI Creative Commons

Yan Zhou,

Yong Han, Qing Shu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract Objective Evidence linking non-obese non-alcoholic fatty liver disease (NAFLD) with residual cholesterol (RC) is weak. In this study, Chinese adults who were not obese examined for a relationship between NAFLD and RC levels. Methods 16,004 volunteers included in retrospective cohort study at clinic the start of 2010 end 2014. The correlation initial levels likelihood developing was investigated using proportional hazards regression (Cox) model. Using cubic spline functions smooth curve fitting technique, two-piecewise method used to investigate nonlinear associations NAFLD. There numerous sensitivity assessments carried out. information posted on DATADRYAD website. Results results showed positive incidence after controlling variables (HR = 1.061, 95% CI 1.045–1.078). Between NAFLD, connection found, turning point 98.29 mg/dL. effect sizes (HR) 1.150 (95% 1.106, 1.194) 1.009 0.982, 1.037) either side point, respectively. A examination further supported stability findings. Conclusion sample that obese, research emphasizes potentially favorable risk. When below mg/dL, substantially associated risk Thus, from therapeutic standpoint, keeping cutoff would be advantageous.

Language: Английский

Association between remnant cholesterol and chronic kidney disease: Systematic review and meta‐analysis DOI Creative Commons
Paschalis Karakasis, Dimitrios Patoulias, Manfredi Rizzo

et al.

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Background and Aims Adequate lipid control has emerged as a key factor in the prevention management of chronic kidney disease (CKD). Remnant cholesterol (RC), lipoprotein with an established association cardiovascular risk, been investigated context CKD. Given conflicting results from recent studies, we performed this meta‐analysis to summarize existing evidence on between RC Methods Medline, Cochrane Library Scopus were searched until 16 September 2024. Double‐independent study selection, data extraction quality assessment performed. Evidence was pooled using random‐effects meta‐analyses. We set primary end‐point interest Results Twelve studies (4 139 674 participants) included. Participants values highest quantile had significantly greater odds CKD compared those lowest (Odds Ratio [OR] = 1.46, 95% confidence interval [CI] 1.26–1.68). In sensitivity analysis confined subjects type 2 diabetes (T2D), higher also exhibited increased (OR CI 1.20–1.78). A significant inverse observed estimated glomerular filtration rate (Mean Difference [MD] −1.43 mL/min/1.73 m for each 1 mmol/L increase RC, [−2.67, −0.19]). Additionally, individuals T2D‐related 24% risk progression end‐stage renal standard deviation (Hazard [HR] 1.24, 1.04–1.47). Conclusions is directly associated Beyond traditional markers, emphasis should be placed levels or at

Language: Английский

Citations

1
Curvilinear association between Framingham Steatosis Index and chronic kidney disease: a nationwide cross-sectional study DOI Creative Commons
Chunqi Jiang, Wei Wang, Jun Wang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 14, 2025

Introduction Fatty liver disease is potentially linked to chronic kidney (CKD), yet the association between Framingham Steatosis Index (FSI) and CKD remains uncharted. Our study thoroughly investigated correlation FSI CKD, aiming elucidate underlying links these two conditions. Methods The relationship was evaluated using a weighted multivariate logistic regression model, curvilinear explored through smooth curve fitting. We engaged recursive partitioning algorithm in conjunction with two-stage linear model determine inflection point. By conducting stratified analyses, heterogeneity within subpopulations explored. Results In fully adjusted Model 3, which accounted for all covariates, odds ratios (ORs) (95% CI) were 1.01 (0.97, 1.06), indicating no significant statistical association. Sensitivity analysis confirms stability of CKD. Smooth fitting discloses non-linear two-piecewise applied explore this non-linearity, identified an point at value −3.21. Below threshold, OR 0.25 (0.17, 0.37), signifying inverse Above point, 1.19 (1.13, 1.25), suggesting positive correlation. analysis, results essentially consistent overall findings, except subgroups BMI > 30 age 50. Conclusion found

Language: Английский

Citations

0
Association between Remnant Cholesterol and All-Cause and Cardiovascular Mortality Risk in Chronic Kidney Disease Patients Over 60: A Cohort Study Based on NHANES 2001-2018 DOI Creative Commons
James C. Yao, Chun Lin, Qingbo Xu

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Abstract Objective Chronic kidney disease (CKD) patients face significant mortality risks, and remnant cholesterol (RC) may be a critical prognostic indicator. This study aimed to explore the association between RC all-cause cardiovascular risks in CKD patients. Methods prospective cohort utilized data from National Health Nutrition Examination Survey (NHANES) 2001-2018, including 1,606 aged over 60. Cox proportional hazards models were employed assess mortality, with multi-model adjustments subgroup analyses. Results During 93.9 months of follow-up, 932 events (58.0%) 283 (17.6%) observed. Each logarithmic unit increase was associated 41% reduction risk (adjusted HR: 0.59, 95% CI: 0.40-0.87, P=0.0079). Subgroup analyses revealed significantly reduced women (HR=0.71), hypertensive (HR=0.75), type 2 diabetes (HR=0.66). Conclusion In patients, is risk, providing new perspective for individualized assessment.

Language: Английский

Citations

0
Association of the remnant cholesterol to high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients DOI Creative Commons
Zebin Wang, Shihao Huang,

Na Tian

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 21, 2025

In individuals receiving continuous ambulatory peritoneal dialysis (CAPD), remnant cholesterol (RC) and high-density lipoprotein (HDL-C) levels significantly influence clinical outcomes. Current practice might benefit from assessing these two lipid markers in combination when evaluating cardiovascular disease (CVD) all-cause mortality. Therefore, this research sought to examine how the RC/HDL-C ratio correlates with both CVD mortality rates among CAPD treatment. Between January 1, 2005 December 31, 2016, a multi-center retrospective analysis of 2006 patients five hospitals China was conducted. Participants were split into subgroups accordance baseline serum restricted cubic spline cutoff value. The correlations between examined through case-specific hazard modeling. observation period documented 549 fatalities, deaths accounting for 269 cases. Kaplan-Meier revealed statistically significant divergence (log rank test P < 0.001) = 0.003). Elevated ratios showed increased (HR) (1.335, 95% CI, 1.112–1.603, 0.002) (1.319, 1.013–1.717, 0.040) compared lower counterparts. Nevertheless, no meaningful association found either RC (HR: 1.296, 0.992–1.691, 0.057) or HDL-C 0.887, 0.680–1.157, 0.376). independently predicts patients, persisting as prognostic marker after multivariable adjustment.

Language: Английский

Citations

0
Effects of remnant cholesterol on adverse renal outcomes in lupus nephritis DOI Creative Commons
Xiaolei Shi, Xinxin Zhang, Yuewen Lu

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 10, 2025

Remnant cholesterol (RC) causes inflammation and promotes kidney diseases development. However, its role in lupus nephritis (LN) remains unclear. The purpose of this study was to investigate the association between RC LN. This observational conducted among patients enrolled 2000 2018 High Quality Evidence Guangzhou Lupus Nephritis Cohort. outcomes were defined as adverse renal outcomes, including serum creatinine doubled end-stage disease. Patients stratified into lower higher groups based on optimal cutoff value (86.88 mg/dL) for outcomes. To explore RC, survival analyses, multivariate Cox regression subgroup analyses conducted. Overall, 909 individuals enrolled. Over a median follow-up 8.33 (interquartile range, 3.08-12.83) years, 134(14.74%) them reached endpoints. Kaplan-Meier indicated that with levels more susceptible LN (P < 0.001). After adjusting confounding factors, exhibited significant correlations [hazard ratio (HR):1.98, 95% confidence interval (CI):1.16-3.39; P = 0.012]. Subgroup revealed strong relationship particularly aged 40 an estimated glomerular filtration rate 60 ml/min/1.73m2 or proliferative pathological changes nephrotic syndrome 0.05). Higher significantly associated poor LN, indicating may become non-invasive prognostic tool clinical assessment

Language: Английский

Citations

0
Remnant cholesterol has a nonlinear association with non-alcoholic fatty liver disease: A secondary retrospective cohort study in non-obese Chinese adults DOI Creative Commons

Yan Zhou,

Yong Han, Qing Shu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract Objective Evidence linking non-obese non-alcoholic fatty liver disease (NAFLD) with residual cholesterol (RC) is weak. In this study, Chinese adults who were not obese examined for a relationship between NAFLD and RC levels. Methods 16,004 volunteers included in retrospective cohort study at clinic the start of 2010 end 2014. The correlation initial levels likelihood developing was investigated using proportional hazards regression (Cox) model. Using cubic spline functions smooth curve fitting technique, two-piecewise method used to investigate nonlinear associations NAFLD. There numerous sensitivity assessments carried out. information posted on DATADRYAD website. Results results showed positive incidence after controlling variables (HR = 1.061, 95% CI 1.045–1.078). Between NAFLD, connection found, turning point 98.29 mg/dL. effect sizes (HR) 1.150 (95% 1.106, 1.194) 1.009 0.982, 1.037) either side point, respectively. A examination further supported stability findings. Conclusion sample that obese, research emphasizes potentially favorable risk. When below mg/dL, substantially associated risk Thus, from therapeutic standpoint, keeping cutoff would be advantageous.

Language: Английский

Citations

0