Association between lactate-to-albumin ratio and all-cause mortality in critically ill cirrhotic patients with sepsis: a retrospective analysis of the MIMIC-IV database

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 24, 2025

The impact of lactate-to-albumin ratio (LAR) on mortality critically ill cirrhotic patients with sepsis is scant. Critically were obtained from the MIMIC-IV database (v3.0). Cox regression models alone and in combination restricted cubic splines, generalized additive smoothed curve fitting used to investigate relationship between LAR all-cause mortality. A total 1864 included. 30-day, 90-day, 180-day rates 38.0%, 46.3%, 49.5%, respectively. Higher significantly nonlinearly associated higher risks (all adjusted HR = 1.17, P < 0.001). L-shaped associations observed, an inflection point 1.05 (P for log-likelihood 0.01). Compared 1.05, ≥ had (adjusted (95% CI): 1.48 (1.27–1.72), 1.44 (1.25–1.66), 1.38 (1.21–1.57), respectively). No potential modifiers found was positively sepsis. Thus, it could be as a prognostic biomarker.

Language: Английский

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Association between lactate-albumin ratio and 28-day mortality in patients with sepsis-associated acute kidney injury: a retrospective cohort study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 24, 2025

The aim of this study was to investigate the correlation between lactate-albumin ratio (LAR) and 28-day mortality in patients with sepsis combined acute kidney failure (SA-AKI). based on eICU database collected data from 1855 SA-AKI. relationship LAR in-hospital assessed using multivariate Cox regression models Kaplan-Meier survival analysis. A generalised summation model also used analyse non-linear mortality. results showed that rate 19.46% (361/1,855), a significant positive (HR: 1.26, 95% CI: 1.18–1.35, p < 0.001). curve highest quartile (Q4) had lowest rate. Non-linear analysis when less than 2.1, increased each 1-unit increase ratio, an adjusted hazard 1.48 (95% CI 1.20, 1.84, For SA-AKI, nonlinear risk death observed, higher associated

Language: Английский

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Aldehyde Dehydrogenase 2 Lactylation Aggravates Mitochondrial Dysfunction by Disrupting PHB2 Mediated Mitophagy in Acute Kidney Injury

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract Mitochondrial dysfunction is a crucial event in acute kidney injury (AKI), leading to metabolic shift toward glycolysis and increased lactate production. Lactylation, posttranslational modification derived from lactate, plays significant role various cellular processes, yet its implications AKI remain underexplored. Here, marked increase levels pan‐Kla are observed tissue patients mice, with pronounced lactylation activity injured proximal tubular cells identified by single‐cell RNA sequencing. The of aldehyde dehydrogenase 2 (ALDH2) at lysine 52 (K52la), revealing that ALDH2 exacerbates mitochondrial dysfunction. Conversely, the K52R mutation alleviates these injuries HK‐2 adeno‐associated virus‐infected tissues mice. Furthermore, can be modulated upregulating SIRT3 vivo vitro, which reduces lactylation, mitigating Mechanistically, immunoprecipitation‐mass spectrometry analysis demonstrates an interaction between prohibitin (PHB2), mitophagy receptor. promotes ubiquitination‐proteasomal degradation PHB2 inhibit worsen These findings highlight critical endogenous propose as potential therapeutic target.

Language: Английский

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Association between lactate-to-albumin ratio and short-term prognosis of acute-on-chronic liver failure treated with artificial liver support system

European Journal of Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 37(3), P. 327 - 336

Published: Nov. 26, 2024

The impact of lactate-to-albumin ratio (LAR) on the outcome acute-on-chronic liver failure (ACLF) is scant. To investigate relationship between LAR and short-term prognosis in patients with COSSH (Chinese Group Study Severe Hepatitis B) ACLF. A retrospective cohort study was conducted ACLF treated an artificial support system. Restricted cubic splines, linear regression models, Cox models were used to relationships disease severity 28-day prognosis. transplant-free overall survival rates 258 eligible 76.4% 82.2%, respectively. survivors lower than that transplant or death [0.74 (0.58-0.98) vs. 1.03 (0.79-1.35), P < 0.001]. positively associated severity, [adjusted hazard (HR) (95% confidence interval (CI)) for death: 2.18 (1.37-3.46), = 0.001], HR CI) 2.14 (1.21-3.80), 0.009]. Compared 1.01, ≥ 1.01 had poor [all adjusted > 1, 0.05]. Lactate not a potential modifier

Language: Английский

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Association between serum calcium level and the risk of acute kidney injury in patients with acute myocardial infarction: evidences from the MIMIC-IV database

Renal Failure, Journal Year: 2024, Volume and Issue: 46(2)

Published: Sept. 9, 2024

This cohort study was to assess the association between serum calcium levels and risk of acute kidney injury (AKI) in myocardial infarction (AMI) patients.

Language: Английский

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Lactate to Albumin Ratio and Mortality in Patients with Severe Coronavirus Disease-2019 Admitted to an Intensive Care Unit

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7106 - 7106

Published: Nov. 24, 2024

This study sought to evaluate the effectiveness of lactate/albumin ratio for ICU mortality prediction in a large cohort patients with severe Coronavirus Disease-2019 (COVID-19) admitted an intensive care unit (ICU).

Language: Английский

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