Causal associations between environmental factors and risk of IgA nephropathy and membranous nephropathy: a bidirectional Mendelian randomization and mediation analysis DOI Creative Commons
Chunmin Li, Wen Qian, Yanxia Zhang

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: April 9, 2025

IgA nephropathy (IgAN) and membranous (MN) have intricate etiologies that are poorly understood. This study aimed to investigate the impact of genetically predicted environmental factors on IgAN MN. We used bidirectional two-step Mendelian randomization (MR) analysis utilizing large-scale genome-wide association (GWAS) data relationships between 68 exposures The main method is inverse variance weighted (IVW). Sensitivity analyses were conducted validate causal estimates. Furthermore, MR was explore possible mediating effects. A total 20 significant associations identified. Genetically educational attainment (EA), average household income, gluten-free diet, cheese intake, fresh fruit cognitive performance, intelligence associated with a reduced risk (p < 0.05); whereas frequency alcohol consumption, insomnia, triglycerides, transferrin saturation, percentage body fat, mass index (BMI), waist circumference, blood pressure 0.05). EA moderate vigorous physical activity MN other hand, beef waist-to-hip ratio, nitrogen oxides In addition, we observed BMI, circumference partially mediated link IgAN, mediation proportions 12.52%, 11.06%, 9.93%, respectively. provides novel evidence These findings may inform targeted prevention strategies contribute improved disease assessment.

Language: Английский

Causal insights into major risk factors for diabetic kidney disease: a comprehensive meta-analysis and Mendelian randomization study DOI Creative Commons
Yucong Zhou, Yahong Liu, Liang Wu

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: Feb. 26, 2025

Background This study aims to identify major risk factors for diabetic kidney disease (DKD) and examine their causal relationships using meta-analysis Mendelian randomization.

Language: Английский

Citations

0
The association between immune cells and acute kidney injury: insights from Mendelian randomization DOI Creative Commons

Xianzhen Yang,

Xiaolei Zhang, Denglu Zhang

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: March 2, 2025

Language: Английский

Citations

0
Educational attainment, body mass index, and smoking as mediators in kidney disease risk: a two-step Mendelian randomization study DOI Creative Commons
Lei Zhang,

Baiyu Feng,

Zhiwen Liu

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: March 11, 2025

Background Educational attainment (EA) has been linked to various health outcomes, including kidney disease (KD). However, the underlying mechanisms remain unclear. This study aims assess causal relationship between EA and KD quantify mediation effects of modifiable risk factors using a Mendelian randomization (MR) approach.

Language: Английский

Citations

0
Causal impact of elevated body mass index on diabetic kidney disease: an integrated Mendelian randomization and Global Burden of Disease Study 2021 analysis DOI Creative Commons

Yexin Chen,

Dong-sen Hu,

Mon-Jyh Lin

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: March 17, 2025

Background Elevated body mass index (BMI) has been implicated in the pathogenesis of diabetic kidney disease among patients with type 2 diabetes mellitus (T2DKD). However, establishing a causal relationship and quantifying resultant global health impact remain challenging.

Language: Английский

Citations

0
Genetic insights into blood urea nitrogen as a risk factor for coronary artery disease: a Mendelian randomization study in East Asians DOI Creative Commons
Lijuan Shen,

Qianxin Zhang,

Zhouyang Zhu

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: March 17, 2025

Previous studies have reported the association between blood urea nitrogen (BUN) and cardiovascular diseases (CVDs) but causality has not yet been proved. Our study aimed to assess causal effect of BUN levels on several CVDs using two-sample Mendelian randomization (MR) method. This is first MR examining relationships multiple diseases. Using data from genome-wide (GWAS) East Asians, we identified single nucleotide polymorphisms (SNPs) associated with as instrumental variables. Specifically, SNPs reaching significance (p < 5 × 10-8) were selected a large-scale dataset comprising (n = 148,767). To ensure robustness, methods, including MR-Egger, weighted median, inverse variance weighting (IVW), simple mode, employed evaluate relationship CVDs. Sensitivity analyses conducted reliability stability results. The IVW approach showed that higher level was an increased risk coronary artery disease (CAD) (OR 1.42, 95% CI 1.226 - 1.644, p 2.89 10-6). For atrial fibrillation 0.868, 0.678 1.110, 0.258), arrhythmia 0.907, 0.777 1.059, 0.216), congestive heart failure 0.924, 0.781 1.092, 0.353), no significant associations found. indicated results robust. work shows elevated are potential biomarker for CAD lack other These findings suggest avenues stratification prevention strategies, emphasizing clinical utility monitoring in at-risk populations.

Language: Английский

Citations

0
Long nighttime sleep duration and risk of renal tubular damage: evidence from rural China and a Mendelian randomization analysis DOI Creative Commons

JingJing Quan,

Li Chen, Weilin Chen

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: March 17, 2025

Objective Renal tubular damage, a pivotal pathological feature of chronic kidney disease (CKD), predicts progression. While extreme nighttime sleep duration is linked to glomerular injury by prior studies, its impact on damage remains unclear. Given that 7–9 h per night widely recommended for maintaining overall health, this study aimed assess whether long associated with renal using both observational and genetic evidence.

Language: Английский

Citations

0
Causal associations between environmental factors and risk of IgA nephropathy and membranous nephropathy: a bidirectional Mendelian randomization and mediation analysis DOI Creative Commons
Chunmin Li, Wen Qian, Yanxia Zhang

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: April 9, 2025

IgA nephropathy (IgAN) and membranous (MN) have intricate etiologies that are poorly understood. This study aimed to investigate the impact of genetically predicted environmental factors on IgAN MN. We used bidirectional two-step Mendelian randomization (MR) analysis utilizing large-scale genome-wide association (GWAS) data relationships between 68 exposures The main method is inverse variance weighted (IVW). Sensitivity analyses were conducted validate causal estimates. Furthermore, MR was explore possible mediating effects. A total 20 significant associations identified. Genetically educational attainment (EA), average household income, gluten-free diet, cheese intake, fresh fruit cognitive performance, intelligence associated with a reduced risk (p < 0.05); whereas frequency alcohol consumption, insomnia, triglycerides, transferrin saturation, percentage body fat, mass index (BMI), waist circumference, blood pressure 0.05). EA moderate vigorous physical activity MN other hand, beef waist-to-hip ratio, nitrogen oxides In addition, we observed BMI, circumference partially mediated link IgAN, mediation proportions 12.52%, 11.06%, 9.93%, respectively. provides novel evidence These findings may inform targeted prevention strategies contribute improved disease assessment.

Language: Английский

Citations

0