Cited by COVID-19 vaccine-related pathologies: cardiac and neurological side effects and Long-term COVID-19

Transfusions of Blood Products Derived from Genetic Vaccine Recipients: Safety Concerns and Proposals for Specific Measures DOI

Jun Ueda, Hideyuki Motohashi,

Yuriko Hirai

et al.

Published: May 29, 2024

The World Health Organization declared the coronavirus disease 2019 (COVID-19) pandemic in 2020, following which a global genetic vaccination program has been rapidly implemented as fundamental solution. However, it reported worldwide that modified mRNAs encoding spike proteins and lipid nanoparticles, are used drug delivery systems, not only cause thrombosis cardiovascular disorders post vaccination, but might also diverse diseases involving all organs including nervous system. Furthermore, toxicity pathogenicity of may necessitate defining these nonbiological infective material. Based on reports abundant evidence come to light past few years, this paper aims draw attention medical professionals various risks associated with transfusion using blood products derived from long COVID patients or vaccine recipients, make proposals regarding specific inspection items, testing methods, regulations, etc. This provides insights address post-vaccination syndrome its consequences such programs.

Language: Английский

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A Case Report of Acute Lymphoblastic Leukaemia (ALL)/Lymphoblastic Lymphoma (LBL) Following the Second Dose of Comirnaty®: An Analysis of the Potential Pathogenic Mechanism Based on of the Existing Literature DOI

Patrizia Gentilini,

Janci C. Lindsay,

Nafuko Konishi

et al.

Published: March 27, 2024

In this report we describe the case of a healthy, young, athletic woman who developed acute lymphoblastic leukaemia (ALL)/lymphoblastic lymphoma (LBL) after receiving second dose Pfizer/BioNTech modified mRNA (modRNA) COVID-19 genetic vaccine (marketed as Comirnaty®). The first did not appear to illicit any noticeable side effects, but within 24 hours patient suffered widespread and intensifying bone pain, fever, vomiting, general malaise. Due persistence symptoms, underwent series tests examinations including full laboratory workup, consult with clinical immunologist rheumatologist, Positron Emission Tomography (PET) imaging, well an osteomedullary biopsy. These together led definitive diagnosis ALL. A time interval 16 weeks from vaccination cancer was noted. Several similar cases identical pathology which modRNA vaccination, are described in reports scientific literature. massive indiscriminate use vaccines fight is raising serious concerns about their safety technology platform whole for purpose. Growing evidence accumulating regarding biodistribution can reach, thanks lipid nanoparticles, multitude tissues organs body, marrow other blood-forming tissues. Moreover, there that display particular tropism marrow, influencing immune system at multiple levels being able trigger only autoimmune-based pathologies, also neoplastic mechanisms. aim article assess, on basis available literature, risk developing haematopoietic cancers investigate potential mechanisms involved pathogenesis disease.

Language: Английский

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Patrizia Gentilini,

Janci C. Lindsay,

Nafuko Konishi

et al.

Published: April 1, 2024

Language: Английский

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Case Report: New-onset relapsing-remitting multiple sclerosis with positive Uhthoff phenomenon after second BNT162b2 dose DOI

Josef Finsterer, Neil M. D’Souza

F1000Research, Journal Year: 2024, Volume and Issue: 13, P. 943 - 943

Published: Aug. 20, 2024

Objectives new-onset relapsing-remitting multiple sclerosis (RRMS) has rarely been communicated as a side effect of SARS-CoV-2 vaccination (SC2V). Here we report patient with RRMS shortly after the second BNT162b2 vaccine dose, which was diagnosed only relapse third dose. Case is 31 year-old male who developed eye problems 48 days dose BNT162b2. The symptoms were attributed to strain and gradually disappeared without treatment. Further workup negative. Three months urinary urgency developed. Eleven he sensory visual disturbances that noticeable post-exercise progressed worsened alcohol heat. MRI showed typical lesions met Barkhof/Tintore criteria for RRMS. Cerebrospinal fluid (CSF) studies revealed elevated kappa free light chains positive oligoclonal bands. Because revised McDonalds met, ocrelizumab started. Conclusions this case shows can trigger RRMS, clinical presentation SC2V-induced similar due other triggers, severity relapses may increase number boosters given. Although, rare, neurologist should be aware presumably rare event in SC2V triggers sclerosis.

Language: Английский

Citations

The WHO Algorithm for Causality Assessment of Adverse Effects Following Immunization with Genetic-Based Anti-COVID-19 Vaccines: Pitfalls and Suggestions for Improvement DOI

Paolo Bellavite, Alberto Donzelli, Ciro Isidoro

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7291 - 7291

Published: Nov. 30, 2024

Clarifying and differentiating the causes of diseases is an essential step in any clinical activity, but it takes on particular relevance complexity case that arise following vaccinations. The WHO has proposed a protocol uses list specific questions about vaccine-related adverse events algorithm for making judgement. Here, we analyze discuss important limitations this when applied to new genetic-based anti-COVID-19 vaccines, particularly once dealing with rare unexpected pathological events. main controversial aspects concern: (a) prevailing consideration other possible causes; (b) biological plausibility choice appropriate time window consider effects possibly caused by vaccines; (c) reference scientific literature, which may be very limited often early stages introducing vaccines because short period observation; (d) final classification into only three classes, leaves ample space "indeterminate" category. Failure address these issues lead distorted pharmacovigilance reports significant consequences benefit/harm assessment. In anticipation future pandemics managed needs revised protocols monitoring evaluation take account novel mechanism action real-world epidemiological data.

Language: Английский

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Autoantibodies Targeting G-Protein-Coupled Receptors and RAS-Related Molecules in Post-Acute COVID Vaccination Syndrome: A Retrospective Case Series Study DOI

Mauro Mantovani, Paolo Bellavite, Sergio Fazio

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2852 - 2852

Published: Dec. 15, 2024

Background/Objectives: While post-acute COVID-19 syndrome is well known and extensively studied, the COVID vaccination (PACVS) a more recent nosological entity that poorly defined at immunopathological level, although it shares many symptoms with sequelae of viral infections. Methods: This single-center retrospective study reports case series 17 subjects vaccinated mRNA or adenoviral vector vaccines who were healthy before had never been infected SARS-CoV-2 but presented similar to PACVS for median time 20 months (min 4, max 32). The medical records all patients referred our outpatient clinic over one-year period retrospectively analyzed. Results: In this group, serological tests showed that, in addition positivity anti-spike protein antibodies, high percentage positive antibodies against G protein-coupled receptors molecules involved response SARS-CoV-2. panel 16 autoantibodies tested, few positively associated some reported by patients: anti-ATR1 lymphadenopathy and/or tonsillitis; anti-ACE2 skin such as ecchymosis, oedema, rash; anti-MAS1 widespread burning sensation; anti-STAB1 oedema rash. Anti-ADRA2A negatively memory loss mental fog. ACE2 correlated serum levels anti-S supporting hypothesis an anti-idiotype mechanism immunopathogenesis PACVS. Conclusions: exploratory analysis suggests directed ACE2, probably also MAS1 STAB1, may serve biomarkers

Language: Английский

Citations

COVID-19 vaccine-related pathologies: cardiac and neurological side effects and Long-term COVID-19 DOI

Beril Anılanmert, Fatma Çavuş Yonar, Gülten Rayimoğlu

et al.

Journal of Research in Pharmacy, Journal Year: 2023, Volume and Issue: 27(6)(27(6)), P. 2559 - 2591

Published: Jan. 1, 2023

Soon after the commencement of mass immunization programs, safety COVID-19 vaccines became a top issue.An increase is noticed in literature complaints and complications among public due to variety adverse reactions, ranging from most minor ones like fever, local pain, myalgias several potentially serious cardiac neurological blood clotting, Bell's palsy, myocarditis, hypertensive crisis, pericarditis, other cardiovascular events.Transverse myelitis, cerebral venous thrombosis, acute inflammatory demyelinating polyneuropathy were only few many more conditions.Most function through expressing spike protein.They accomplish this either by transfecting cells with mRNA or infecting them an adenovirus containing gene.When expressed, immune system recognizes it as foreign antigen mounts attack on protein consequently SARS-CoV-2 case any contagion.However, virus's primary mechanism for infection accountable majority that COVID 19 brought.When exists produced sufficient quantities body, can mimic partially pathological picture, including cytokine storm, particularly following vaccinations infected people.In order know long-term new vaccine type pharmaceutical product, clinical data should be continuously collected reactions using country's effective pharmacovigilance systems questioning vaccination effect during diagnosis hospitals.

Language: Английский

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