A detailed insight into the role of nanosized drug carriers for the management of diabetic wounds

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106688 - 106688

Published: Feb. 1, 2025

Language: Английский

Photocatalysis and Photodynamic Therapy in Diabetic Foot Ulcers (DFUs) Care: A Novel Approach to Infection Control and Tissue Regeneration

Molecules, Journal Year: 2025, Volume and Issue: 30(11), P. 2323 - 2323

Published: May 26, 2025

Photocatalysis and photodynamic therapy have been increasingly used in the management of diabetic foot ulcers (DFUs), their integration into innovative treatment protocols enables effective infection control. Advanced techniques such as antibacterial (aPDT), liposomal photocatalytic carriers, nanoparticles, nanomotors—used alone, combination, or with addition antibiotics, lysozyme, phage enzymes—offer promising solutions for wound treatment. These approaches are particularly even presence comorbidities angiopathies, neuropathies, immune system disorders, which common among patients. Notably, use combination therapies holds great potential addressing challenges within ulcers, including hypoxia, poor circulation, high glucose levels, increased oxidative stress, rapid biofilm formation—factors that significantly hinder healing The modern therapeutic strategies is essential clinical practice, starting halting progression, ensuring its eradication, promoting proper tissue regeneration, especially considering that, according to WHO, 830 million people worldwide suffer from diabetes.

Language: Английский

Mechanistic insights of diabetic wound: Healing process, associated pathways and microRNA-based delivery systems

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125117 - 125117

Published: Dec. 1, 2024

Language: Английский