Evolution of an epidemic: Understanding the opioid epidemic in the United States and the impact of the COVID-19 pandemic on opioid-related mortality

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(7), P. e0306395 - e0306395

Published: July 9, 2024

We conduct this research with a two-fold aim: providing quantitative analysis of the opioid epidemic in United States (U.S.), and exploring impact COVID-19 pandemic on opioid-related mortality. The duration persistence lends itself to need for an overarching extensive scope. Additionally, studying ramifications these concurrent severe public health crises is vital informing policies avoid preventable Using data from CDC WONDER, we consider deaths grouped by Census Region spanning January 1999 October 2022 inclusive, later add demographic component gender-stratification. Through lens key events epidemic, build interrupted time series model reveal statistically significant drivers then employ counterfactual approximate trends absence COVID-19, estimate excess (defined as observed minus projected deaths) associated pandemic. According our model, proliferation fentanyl contributed sustained increases death rates across three four U.S. census regions, corroborating existing knowledge field. Critically, each region has immediate increase its monthly rate at least 0.31 per 100,000 persons start pandemic, highlighting nationwide knock-on effects COVID-19. There are consistent positive deviations expected sizable burden cumulative deaths, surpassing 60,000 additional nationally March 2020 2022, ∼70% which were male. These results suggest that robust, multi-faceted measures even more important light prevent overdoses educate users risks potent synthetic opioids such fentanyl.

Language: Английский

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Increased Risk of Breakthrough SARS-CoV-2 Infections in Patients with Colorectal Cancer: A Population-Based Propensity-Matched Analysis

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(9), P. 2495 - 2495

Published: April 24, 2024

Background/Objectives: This study aimed to investigate the association between colorectal cancer (CRC) and risk of breakthrough respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in vaccinated patients with CRC. Methods: retrospective cohort used TriNetX research network identify Patients were matched using propensity score matching (PSM) divided into CRC control (without history CRC) groups. The primary outcome was SARS-CoV-2 patients. secondary a composite all-cause emergency department (ED) visits, hospitalization, death during follow-up period after diagnosis COVID-19. Results: A total 15,416 identified without had significantly increased for infections compared (aOR = 1.78; [95% CI: 1.47–2.15]). at two doses 1.71; 1.42–2.06]) three 1.36; 1.09–1.69]) vaccine. Vaccinated lower COVID-19 than unvaccinated 0.342; 0.289–0.404]). overall (all-cause ED death) 51.6% infections, which greater 44.3% score-matched 1.79; 1.29–2.47]). Conclusions: showed risks Breakthrough associated significant substantial hospitalizations.

Language: Английский

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Epidemiology of Elderly Burn Patients in the United States: Mortality Patterns and Risk Factors Revealed by CDC Wonder Database

Burns, Journal Year: 2024, Volume and Issue: 51(1), P. 107311 - 107311

Published: Nov. 9, 2024

Language: Английский

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Learning from the past: Pandemics, genetics, and health disparities

Baylor University Medical Center Proceedings, Journal Year: 2023, Volume and Issue: 37(1), P. 34 - 35

Published: Nov. 14, 2023

"Learning from the past: Pandemics, genetics, and health disparities." Baylor University Medical Center Proceedings, ahead-of-print(ahead-of-print), pp. 1–2

Language: Английский

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