Journal of Dispersion Science and Technology,
Journal Year:
2022,
Volume and Issue:
45(2), P. 224 - 233
Published: Nov. 14, 2022
The
present
study
investigates
and
highlights
the
potency
of
tacrolimus
(TAC)
for
effective
vitiligo
management
using
cubosome
gel
formulation.
TAC-loaded
formulations
were
prepared
by
ultrasonication
technique.
central
composite
design
(CCD)
statistical
was
employed
optimization
based
on
responsible
variables
like
particle
size
entrapment
efficiency.
optimized
(F-14)
subjected
to
physicochemical
characterizations,
including,
zeta
potential
analysis,
SEM,
drug
loading
release
profiling
assessment.
SEM
imaging
confirmed
spherical
morphology
TAC
loaded
cubosome.
Drug
percentage
from
found
be
with
controlled
73%
12
hour
kinetics
follows
zero-order
Fickian
diffusion
mechanism.
formulation
incorporated
in
Carbopol
934
topical
application
(TAC-CG)
vitiligo.
Therapeutic
efficacy
TAC-CG
control
inflammation
condition
assessed
monobenzene
(60%)
induced
model
C57BL/6
mice.
treatment
exhibited
a
significant
reduction
depigmentation
as
response
when
compared
that
monobenzene-sensitized
normal
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Jan. 12, 2023
Skin
cancer
has
emerged
as
the
fifth
most
commonly
reported
in
world,
causing
a
burden
on
global
health
and
economy.
The
enormously
rising
environmental
changes,
industrialization,
genetic
modification
have
further
exacerbated
skin
statistics.
Current
treatment
modalities
such
surgery,
radiotherapy,
conventional
chemotherapy,
targeted
therapy,
immunotherapy
are
facing
several
issues
related
to
cost,
toxicity,
bioavailability
thereby
leading
declined
anti-skin
therapeutic
efficacy
poor
patient
compliance.
In
context
of
overcoming
this
limitation,
nanotechnological
advancements
been
witnessed
so
far.
Among
various
nanomaterials,
nanoparticles
endowed
exorbitant
advantages
by
acting
both
agents
drug
carriers
for
remarkable
cancer.
small
size
large
surface
area
volume
ratio
escalate
tumor
uptake
through
their
leaky
vasculature
resulting
enhanced
efficacy.
context,
present
review
provides
up
date
information
about
different
types
pathology
cancer,
followed
current
associated
drawbacks.
Furthermore,
it
meticulously
discusses
role
numerous
inorganic,
polymer,
lipid-based
therapy
with
subsequent
descriptions
patents
clinical
trials.
Photodiagnosis and Photodynamic Therapy,
Journal Year:
2024,
Volume and Issue:
45, P. 103959 - 103959
Published: Jan. 21, 2024
Breast
cancer
(BC)
remains
an
enigmatic
fatal
modality
ubiquitously
prevalent
in
different
parts
of
the
world.
Contemporary
medicines
face
severe
challenges
remediating
and
healing
breast
cancer.
Due
to
its
spatial
specificity
nominal
invasive
therapeutic
regime,
photothermal
therapy
(PTT)
has
attracted
much
scientific
attention
down
lane.
PTT
utilizes
a
near-infrared
(NIR)
light
source
irradiate
tumor
target
intravenously
or
non-invasively,
which
is
converted
into
heat
energy
over
optical
fibre.
Dynamic
progress
nanomaterial
synthesis
was
achieved
with
specialized
visual,
physicochemical,
biological,
pharmacological
features
make
up
for
inadequacies
expand
horizon
PTT.
Numerous
nanomaterials
have
substantial
NIR
absorption
can
function
as
efficient
transducers.
It
achievable
limit
wavelength
range
absorbance
peak
specific
by
manipulating
their
synthesis,
enhancing
precision
quality
Along
same
lines,
various
are
conjugated
wide
surface-modifying
chemicals,
including
polymers
antibodies,
may
modify
persistence
diminish
toxicity
concerns.
In
this
article,
we
tend
put
forth
insights
fundamental
conceptualizations
on
pre-existing
advances
upon
conjugation
biocompatible
working
synergy
combat
cancer,
encompassing
several
strategies
like
immunotherapy,
chemotherapy,
photodynamic
therapy,
radiotherapy
coupled
Additionally,
role
mechanisms
nanoparticles,
well
possible
alternatives
PTT,
summarized
distinctive
integral
aspect
article.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 19, 2024
Abstract
Colorectal
cancer,
the
third
most
prevalent
cancer
globally,
contributes
significantly
to
mortality
rates,
with
over
1.9
million
reported
cases
and
nearly
935,000
fatalities
annually.
Surgical
resection
is
a
primary
approach
for
localized
colorectal
tumors,
adjunct
therapies
like
chemotherapy,
radiotherapy,
targeted/immunotherapy
considered
depending
on
tumor
stage.
However,
despite
preferences
targeted
immunotherapy
post-surgery,
chemotherapy
remains
commonly
chosen
due
its
lower
cost
high
cancer-killing
efficiency.
Yet,
faces
issues
such
as
resistance
severe
side
effects.
Nanotechnology
has
emerged
in
therapy
by
alleviating
drawbacks
of
current
treatment
approaches.
In
past
few
decades,
inorganic
nanoparticles
have
shown
promise
combating
offering
advantages
conventional
chemotherapy.
Compared
organic
nanoparticles,
exhibit
properties
photosensitivity,
conductivity,
magnetic
allure,
thermal
proficiency,
allowing
them
function
both
drug
carriers
therapeutic
agents.
Derived
primarily
from
carbon,
silica,
metals,
metal
oxides,
they
offer
superior
drug-loading
capacity,
heightened
quantum
yield,
participation
advanced
photothermal
photodynamic
therapies.
This
review
provides
brief
overview
pathophysiology
pivotal
role
therapy,
delivery.
Additionally,
it
discusses
numerous
based
recent
literature.
Graphical
abstract
