Causal relationship between genetically predicted mental disorders and frailty: a bidirectional and multivariable mendelian randomization study DOI Creative Commons
Wenxi Sun, Ping Sun,

Sijia Tang

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 23, 2024

In observational studies, frailty has been strongly associated with mental disorders. However, the mechanisms underlying association between and disorders remain unclear. We conducted a two-sample Mendelian randomization (MR) study to assess causal relationship frailty, as measured by index (FI), ten common The datasets involved European ancestry individuals included measurements of FI (N = 175,226), schizophrenia (SCZ; N 320,404), major depressive disorder (MDD; 143,265), bipolar 337,199), insomnia 462,341), obsessive–compulsive 33,925), anxiety 463,010), autism spectrum 46,351), anorexia nervosa 14,477), opioid-related behavioral 215,650), due use other stimulants including caffeine 215,570). Two-sample MR analyses were performed using inverse variance weighting followed various sensitivity validation analyses. Genetically predicted SCZ (odds ratio [OR] 1.019, 95% confidence interval [CI] 1.005–1.033) MDD (OR 1.211, CI 1.092–1.343) had significant effects on FI. reverse analysis, we discovered that was significantly causally affected 1.290, 1.133–1.469). No links identified eight Multivariable MR, estimated effect is comparable univariate IVW estimate 1.298; CI, 1.175 1.435), while fails be compared estimate. results confirmed stabilization. Our found evidence SCZ, MDD, explored mechanisms.

Language: Английский

Disparities in anxiety and related factors among Chinese older adults across different aged-care models: a comparison of two cross-sectional studies DOI Creative Commons
Xin Zheng,

Ziwen Xu,

Jie Zhao

et al.

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 21, 2025

Anxiety disorders in older adults have become a prominent public health problem due to their concomitant chronic conditions, reduced quality of life and even death. However, fewer studies been conducted on differences anxiety among individuals different aged-care models, the interactive relationship between influencing factors remains unclear. The study aimed examine disparities prevalence community-dwelling institutionalized related factors. Data were collected from Anhui Healthy Longevity Survey (AHLS) Elderly Caring Social Organizations (AECSOS). demographic variables, lifestyle health-related variables 6968 used for analysis. symptoms evaluated using Generalized Disorder Assessment Scale (GAD-7). Binary logistic regression models Classification Regression Tree model (CART) utilized variables. 24.3% 16.7% adults, respectively. Several including age, gender, residence, education, income level, live alone, number diseases showed linkage with adults. For source income, exhibited significant association anxiety. We noted effect, suggesting that female an level less than 6500 RMB per year reported disease comorbidities had highest likelihood anxiety, sources such as pension, subsidy, family providing, resident rural areas greatest risk experiencing This has brought light higher compared Targeted interventions are, therefore emphasized address negative impact populations at risk.

Language: Английский

Citations

0

Resilience and frailty among gynecological patients in oncological treatment: the chain mediating role of stigma and health literacy DOI Creative Commons

Shuo Man,

Xiaofang Wu,

HaoWen Huang

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: April 2, 2025

Background Frailty poses a significant threat to the health status among gynecological patients in oncological treatment. Previous studies have shown that resilience, stigma, and literacy are associated with frailty. However,65 their effects potential relationship frailty treatment not been fully studied. Objective The study aimed explore mediation role of stigma between resilience Methods A total 202 three wards tertiary hospital Wuxi from March 2024 May were selected for using cross-sectional research method. convenience sampling method was used. Information collected on demographic characteristics, literacy, PROCESS macro program used mediating Results prevalence 27.2%. effect results demonstrated direct predictor (β = -0.010, 95%CI: -0.084 ~0.065) but indirectly predicted through -0.100, -0.155 ~ -0.053) stigma-health -0.056, -0.091 -0.029). However, no alone found -0.038, -0.085 0.005). Conclusions findings reveal impact gynecologic oncology. Health mediated Stigma chain mediators link Healthcare professionals should pay timely attention psychological mental oncology take measures improve literacy.

Language: Английский

Citations

0

Causal relationship between genetically predicted mental disorders and frailty: a bidirectional and multivariable mendelian randomization study DOI Creative Commons
Wenxi Sun, Ping Sun,

Sijia Tang

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 23, 2024

In observational studies, frailty has been strongly associated with mental disorders. However, the mechanisms underlying association between and disorders remain unclear. We conducted a two-sample Mendelian randomization (MR) study to assess causal relationship frailty, as measured by index (FI), ten common The datasets involved European ancestry individuals included measurements of FI (N = 175,226), schizophrenia (SCZ; N 320,404), major depressive disorder (MDD; 143,265), bipolar 337,199), insomnia 462,341), obsessive–compulsive 33,925), anxiety 463,010), autism spectrum 46,351), anorexia nervosa 14,477), opioid-related behavioral 215,650), due use other stimulants including caffeine 215,570). Two-sample MR analyses were performed using inverse variance weighting followed various sensitivity validation analyses. Genetically predicted SCZ (odds ratio [OR] 1.019, 95% confidence interval [CI] 1.005–1.033) MDD (OR 1.211, CI 1.092–1.343) had significant effects on FI. reverse analysis, we discovered that was significantly causally affected 1.290, 1.133–1.469). No links identified eight Multivariable MR, estimated effect is comparable univariate IVW estimate 1.298; CI, 1.175 1.435), while fails be compared estimate. results confirmed stabilization. Our found evidence SCZ, MDD, explored mechanisms.

Language: Английский

Citations

0