Evaluating the Body Roundness Index as a Novel Digital Biomarker for Psoriasis Risk Prediction in a National Population-Based Study (Preprint)

Published: April 10, 2025

Psoriasis, a chronic inflammatory skin disease, is increasingly linked to metabolic disorders, particularly obesity. Traditional anthropometric measures like body mass index (BMI) and waist circumference (WC) have limitations in assessing fat distribution risk. The Body Roundness Index (BRI), which integrates height circumference, may offer superior predictive value for psoriasis risk, but its clinical utility remains underexplored. This study aimed evaluate BRI as potential digital biomarker risk prediction, comparing performance with BMI WC across diverse demographic subgroups using large-scale national health data. We analyzed cross-sectional data from 13,798 adults aged 20–59 years the National Health Nutrition Examination Survey (NHANES, 2003–2014). Psoriasis status was self-reported. BRI, BMI, were calculated standardized measurements. Weighted multivariable logistic regression restricted cubic spline (RCS) models assessed associations, adjusting sociodemographic, metabolic, lifestyle factors. A nomogram model quantified contributions. showed robust linear association (OR=1.11 per unit increase, 95% CI=1.05–1.17, p<0.001), outperforming (OR=1.03) (OR=1.01). Tertile analyses revealed 1.73-fold higher highest group (p=0.003). Subgroup confirmed consistency age, sex, (p interaction >0.05). highlighted BRI’s dominant contribution (largest score-axis span). demonstrates stronger more consistent associations than traditional measures, supporting role early stratification. Integration of into informatics tools could enhance personalized prevention management.

Language: Английский

Mecanismos fisiopatológicos del estrés y las psicodermatosis

Published: Aug. 21, 2024

Mecanismos fisiopatológicos del estrés y las psicodermatosis es una obra fundamental que explora la compleja relación entre el enfermedades de piel, conocidas como psicodermatosis. En un enfoque multidisciplinario abarca dermatología, psiquiatría, neurociencia inmunología, este libro proporciona visión integral los mecanismos subyacentes vinculan con alteraciones cutáneas.

El Rol del Estrés en la Fisiopatología de las Psicodermatosis

Published: Aug. 30, 2024

"El Rol del Estrés en la Fisiopatología de las Psicodermatosis" es una obra pionera que explora compleja interacción entre el sistema nervioso, inmunológico y piel, centrándose cómo estrés psicológico puede desencadenar exacerbar psicodermatosis. Este libro, aborda un tema creciente interés dermatología psiquiatría, ofreciendo visión integral combina teoría, investigación aplicaciones clínicas. Es recurso fundamental para dermatólogos, psiquiatras, psicólogos otros profesionales salud interesados intersección mente piel.