UPLC-ESI/MSn metabolic profiling of Cedrela odorata L. and Toona ciliata M. Roem and in vitro investigation of their anti-diabetic activity supported with molecular docking studies DOI Creative Commons
Heba A. S. El‐Nashar, Ayman M. Al‐Qaaneh, Md. Shimul Bhuia

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 15, 2024

Introduction The genus Cedrela is one of the phytochemically rich genera family Meliaceae. In this study, two species, namely, odorata and Toona ciliata M. Roem (formerly toona ), were selected for in-depth phytochemical profiling with aid UPLC-ESI/MS n analysis followed by evaluation their anti-diabetic potential through assessment in vitro α -amylase -glucosidase inhibitory effects, alongside molecular docking studies on these target enzymes. Materials methods technique was applied to tentatively identify extracts. properties assessed using BioVision inhibitor screening kits. Further, utilized PyRx® Discovery Studio software. Results discussion led identification quantification 55 metabolites fragmentation patterns first time species. Flavonoids represented main identified class, phenylpropanoids, terpenes, tannins, others. species showed potent enzyme inhibition, where C. significantly inhibited (IC 50 = 4.83 ± 0.01 3.50 0.03 μg/mL) compared pioglitazone 2.17 0.23 μg/mL), while -glycosidase also 7.17 6.50 0.69 respectively, acarbose 1.02 μg/mL). activities further confirmed silico components respective binding sockets both Conclusion These promising results could pave way a novel discovery natural phytoconstituents activity.

Language: Английский

Effect of altitude and harvest year on nutraceutical characteristics of Rubus ellipticus fruits DOI Creative Commons

Jyoti Dhatwalia,

Amita Kumari, Ishita Guleria

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 4, 2024

Smith is an evergreen shrub in the Rosaceae family, commonly known as yellow Himalayan raspberry. The objective of this study to determine morphological analysis, minerals, proximate, ascorbic acid, anthocyanins, and carotenoids content

Language: Английский

Citations

3
UPLC-ESI/MSn metabolic profiling of Cedrela odorata L. and Toona ciliata M. Roem and in vitro investigation of their anti-diabetic activity supported with molecular docking studies DOI Creative Commons
Heba A. S. El‐Nashar, Ayman M. Al‐Qaaneh, Md. Shimul Bhuia

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 15, 2024

Introduction The genus Cedrela is one of the phytochemically rich genera family Meliaceae. In this study, two species, namely, odorata and Toona ciliata M. Roem (formerly toona ), were selected for in-depth phytochemical profiling with aid UPLC-ESI/MS n analysis followed by evaluation their anti-diabetic potential through assessment in vitro α -amylase -glucosidase inhibitory effects, alongside molecular docking studies on these target enzymes. Materials methods technique was applied to tentatively identify extracts. properties assessed using BioVision inhibitor screening kits. Further, utilized PyRx® Discovery Studio software. Results discussion led identification quantification 55 metabolites fragmentation patterns first time species. Flavonoids represented main identified class, phenylpropanoids, terpenes, tannins, others. species showed potent enzyme inhibition, where C. significantly inhibited (IC 50 = 4.83 ± 0.01 3.50 0.03 μg/mL) compared pioglitazone 2.17 0.23 μg/mL), while -glycosidase also 7.17 6.50 0.69 respectively, acarbose 1.02 μg/mL). activities further confirmed silico components respective binding sockets both Conclusion These promising results could pave way a novel discovery natural phytoconstituents activity.

Language: Английский

Citations

2