ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Self-assembled fluorescent peptides are promising drug-delivery vehicles targeting cancer cells and enhancing the precision of therapeutic agents. Several systems have been developed including as cysteine-core peptides, cyclic nanostructures peptide polymer conjugates specifically designed for targeted drug delivery. Further, these supramolecular carriers aid in transport by using different cargos like doxorubicin (Dox), paclitaxel (PTX), etc. Additionally, dipeptides such tryptophan-phenylalanine self-assemble via zinc ion chelation, facilitating endosomal escape thereby efficacy within multifunctional nanoparticle systems. Furthermore, pH-activatable enzyme-responsive engineered to exhibit potential controlled release. These self-assembled not only enable delivery but also provide release, with applications extending ocular treatment retinal diseases. possess intrinsic fluorescence properties that allow real-time tracking release cellular uptake, making them highly useful theranostic applications. Moreover, fluorescently tagged cell-penetrating (CPPs) widely used explore how enter cells, revealing multiple ways they taken up, endocytosis, micropinocytosis, direct membrane crossing, counterion-assisted transport. This versatility adds real value peptide-based approaches therapy. Further research advancements should enhance stability, combination therapies, improve clinical translation broader

Language: Английский