Lifetime stressor exposure is related to suicidality in autistic adults: A multinational study DOI Creative Commons
Rachel Moseley, Darren Hedley, Julie M. Turner‐Cobb

et al.

Autism, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Despite very high rates of suicidal thoughts and behaviors (STB) in autistic adults, the key psychosocial drivers this phenomenon remain unknown. To investigate, we examined how lifetime stressor exposure severity, which have been found to predict STB non-autistic populations, related a multinational dataset 226 adults from United Kingdom Australia (67% female; M age = 41.8, SD 13.6, range 19–73 years old). Results revealed that men women differ with respect count, type stressors they experienced over life course. Whereas were exposed more numerous legal/crime-related stressors, social relationships chronic humiliation typically as severe. In addition, whereas interpersonal loss was for men, acute involving physical danger lower entrapment women. These findings indicate certain may be differentially experienced, relevant STB, versus They also suggest screening help identify individuals at greatest risk suicide. Lay abstract When encounter events experience stressful (“stressors”), it sets off biological stress response can impact mental health contribute (STB). Although know about specific are associated general population, little is known kinds increase people whether these associations by gender. examine issue, cataloged entire course investigated STB. Data derived sample who completed Stress Adversity Inventory Adults. We differed terms both well their perceived severity. other long-lasting humiliation. Autistic often severe than important given severity most strongly affects our health. different loved ones women, physically dangerous relevant. fewer had higher results assess understand suicide people. Additional research needed confirm possible mechanisms linking

Language: Английский

The effects of childhood adversity on twenty-five disease biomarkers and twenty health conditions in adulthood: Differences by sex and stressor type DOI Creative Commons
Jenna Alley, Jeffrey Gassen, George M. Slavich

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 123, P. 164 - 176

Published: July 25, 2024

Although early adversity is now recognized as a major public health concern, it remains unclear if the effects of early-life stressors on disease biology and differ by sex or stressor type. Because childhood often covary, examining whether such typically occur together (e.g., cumulative adversity) in distinct multivariate patterns needed to determine how different life uniquely affect health. To investigate, we conducted latent class analyses (LCA) identify clusters adults experiencing multiple (N=2,111, Mage = 53.04, 54.8 % female) Midlife United States (MIDUS) Study. We then tested exposure groups, individual stressors, related 25 biomarkers inflammation, metabolism, stress, 20 conditions. Multivariate effect sizes were estimated using Mahalanobis's D. Optimal LCA models yielded three female (Low-, Moderate-, High-Stress) two male (Low- classes. The High-Stress classes had greater inflammation (male: D=0.43; female: D=0.59) poorer metabolic D=0.32–0.33; D=0.32–0.47). They also more cardiovascular HR=1.56 [1.17, 2.07]; HR=1.97 [1.50, 2.58]), cancer HR=2.41 [1.52, 3.84]; HR=2.51 [1.45, 4.35]), HR=1.54 [1.16, 2.03]; HR=2.01 [1.43, 2.83]), thyroid HR=3.65 [1.87, 7.12]; HR=2.25 [1.36, 3.74]), arthritis HR=1.81 [1.30, 2.54]; [1.41, 2.74]), mental/behavioral problems HR=2.62 [1.90, 3.62]; female; HR=3.67 [2.72, 4.94]). Moreover, these outcomes sex- stressor-specific manner. Childhood portends worse biological elevated risk for many These findings advance stress theory may help inform precision interventions managing stress.

Language: Английский

Citations

5
Possible Anti-Aging and Anti-Stress Effects of Long-Term Transcendental Meditation Practice: Differences in Gene Expression, EEG Correlates of Cognitive Function, and Hair Steroids DOI Creative Commons
Supaya Wenuganen, Kenneth G. Walton, Frederick Travis

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 317 - 317

Published: Feb. 20, 2025

Background: Our previous comparison of peripheral blood mononuclear cells (PBMCs) from long-term Transcendental Meditation® (TM®) practitioners and matched non-practitioner controls found 200 differentially expressed (DE) genes. Bioinformatics analyses these DE genes suggested a reduced risk diseases associated with stress aging in the TM group. Here we assessed additional signs aging. Methods: A sample 15 was studied using qPCR PBMCs 40-year (“Old TM”, n = 23) compared to “Young Control” group (n 19) an “Old 21) non-meditators. In three groups, plus 12-year practitioner 26), also EEG-based parameters cognitive function (the Brain Integration Scale (BIS), latency components event-related potential (ERP)). Finally, LC/MS/MS, persistent levels cortisol (F) its inactive congener, cortisone (E), hair. Results: analysis showed that 13 were more highly Old Controls than Young Controls. group, 7 lower Both groups had higher BIS scores their age-matched controls. The shorter N2, P3a, P3b latencies Control not longer Hair F/Hair E ratio control subgroups subgroups, F combined groups. Conclusions: These results are consistent reductions biomarkers chronic biological age meditators. They study suggesting practice lowers energy consumption or leads efficient metabolism.

Language: Английский

Citations

0
ПЕРСПЕКТИВИ ВІРТУАЛЬНОЇ РЕАЛЬНОСТІ ЯК ІНСТРУМЕНТУ ТЕРАПІЇ ПОСТТРАВМАТИЧНОГО СТРЕСОВОГО РОЗЛАДУ DOI
Тетяна Боцьва,

Ольга Кухарук

ГРААЛЬ НАУКИ, Journal Year: 2025, Volume and Issue: 48, P. 442 - 455

Published: Jan. 10, 2025

ПТСР є поширеним психічним розладом серед осіб, які пережили або постійно знаходяться під впливом травмуючих подій. Офіційна статистика щодо кількості осіб з населення України і, зокрема, військових, наразі відсутня, але очевидно, що терапія серйозним викликом для українського суспільства через втрати продуктивності та вартість лікування. У роботі за даними літератури показано, характеризується дисфункцією автономної нервової системи, яка, у свою чергу, проявляється зниженням варіабельності серцевого ритму (ВСР). Описано переваги показників ВСР як потенційних прогностичних біомаркерів ПТСР. Розглядаються можливі пояснення лікувального впливу терапії десенсибілізації і переробки рухом очей – одного найефективніших заснованих на доказах психологічних методів, рекомендованих лікування ПТСР, зокрема найбільш вірогідний механізм перевантаження робочої пам’яті подвійним завданням. Окреслено можливості застосування сучасної цифрової технології віртуальної реальності створенні додаткових підходів до урахуванням індивідуальних потреб пацієнта. Наведено підтвердження ефективності технологій контролем в час тренування стійкості військових підрозділах.

Citations

0
California Stress, Trauma, and Resilience Study (CalSTARS) protocol: A multiomics-based cross-sectional investigation and randomized controlled trial to elucidate the biology of ACEs and test a precision intervention for reducing stress and enhancing resilience DOI Creative Commons
L. Kim, Sophia Miryam Schüssler‐Fiorenza Rose, Summer Mengelkoch

et al.

Stress, Journal Year: 2024, Volume and Issue: 27(1)

Published: Dec. 2, 2024

Adverse Childhood Experiences (ACEs) are very common and presently implicated in 9 out of 10 leading causes death the United States. Despite this fact, our mechanistic understanding how ACEs impact health is limited. Moreover, interventions for reducing stress use a one-size-fits-all approach that involves no treatment tailoring or precision. To address these issues, we developed combined cross-sectional study randomized controlled trial, called California Stress, Trauma, Resilience Study (CalSTARS), to (a) characterize influence multisystem biological functioning adults with all levels ACE burden current perceived stress, using multiomics other complementary approaches, (b) test efficacy new Precision Intervention Stress (PRECISE) elevated who have experienced full range ACEs. The primary trial outcome secondary outcomes span variety psychological, emotional, biological, behavioral variables, as assessed self-report measures, wearable technologies, extensive biospecimens (i.e. DNA, saliva, blood, urine, & stool) will be subjected genomic, transcriptomic, proteomic, metabolomic, lipidomic, immunomic, metagenomic/microbiome analysis. In protocol paper, describe scientific gaps motivating well sample, design, procedures, planned analyses. Ultimately, goal leverage power cutting-edge tools from psychology, multiomics, precision medicine, translational bioinformatics identify social, molecular, immunological processes can targeted reduce stress-related disease risk enhance biopsychosocial resilience individuals communities worldwide.

Language: Английский

Citations

0
Improving the Conceptualization and Assessment of Adverse Childhood Experiences Using Causal Indicator Models DOI Open Access
Daniel P. Moriarity, George M. Slavich

Published: Aug. 6, 2024

Adverse Childhood Experiences (ACEs) are highly impactful stressors that increase individuals’ risk for a plethora of negative health outcomes. Further, minoritized groups and under-resourced individuals at higher ACEs, positioning these as plausible mechanisms driving disparities. Given this importance, strong methodological foundation is necessary to ensure maximal clinical value. As emphasized by Jensen, Bernard, & Lanier (2024), needs start with rigorous ACEs measurement—a goal requires careful matching between measures the scoring procedures used. To amplify their message while advocating an alternative approach may better reflect conceptualization, we write commentary highlight merits causal indicator models match theory methodology.

Language: Английский

Citations

0
Lifetime stressor exposure is related to suicidality in autistic adults: A multinational study DOI Creative Commons
Rachel Moseley, Darren Hedley, Julie M. Turner‐Cobb

et al.

Autism, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Despite very high rates of suicidal thoughts and behaviors (STB) in autistic adults, the key psychosocial drivers this phenomenon remain unknown. To investigate, we examined how lifetime stressor exposure severity, which have been found to predict STB non-autistic populations, related a multinational dataset 226 adults from United Kingdom Australia (67% female; M age = 41.8, SD 13.6, range 19–73 years old). Results revealed that men women differ with respect count, type stressors they experienced over life course. Whereas were exposed more numerous legal/crime-related stressors, social relationships chronic humiliation typically as severe. In addition, whereas interpersonal loss was for men, acute involving physical danger lower entrapment women. These findings indicate certain may be differentially experienced, relevant STB, versus They also suggest screening help identify individuals at greatest risk suicide. Lay abstract When encounter events experience stressful (“stressors”), it sets off biological stress response can impact mental health contribute (STB). Although know about specific are associated general population, little is known kinds increase people whether these associations by gender. examine issue, cataloged entire course investigated STB. Data derived sample who completed Stress Adversity Inventory Adults. We differed terms both well their perceived severity. other long-lasting humiliation. Autistic often severe than important given severity most strongly affects our health. different loved ones women, physically dangerous relevant. fewer had higher results assess understand suicide people. Additional research needed confirm possible mechanisms linking

Language: Английский

Citations

0