Advancing neurological disorders therapies: Organic nanoparticles as a key to blood-brain barrier penetration

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125186 - 125186

Published: Jan. 8, 2025

The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.

Language: Английский

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Probiotics Encapsulated via Biological Macromolecule for Neurological Therapy and Functional Food: A Review

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

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Polyethylene terephthalate nanoplastics-induced neurotoxicity in adult male Swiss albino mice with amelioration of betaine: a histopathological, neurochemical, and molecular investigation

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Abstract Medicines, food packaging, personal care products, and cosmetics extensively use polyethylene terephthalate nanoplastics (PET-NaPs). However, they also have harmful impacts on several organs. Betaine demonstrates potent antioxidant anti-inflammatory characteristics. Our goal was to investigate the detrimental impact of PET-NaPs mouse brain evaluate neuroprotective properties betaine. We allocated 40 completely mature male Swiss albino mice into four distinct groups: control group, betaine betaine-co-treated group. Following a 30-day duration, euthanasia performed mice, analyzed tissue samples were obtained from cerebrum, cerebellum, hippocampus. resulted in an elevated level malondialdehyde upregulated cyclooxygenase-2 interleukin-1 beta (IL-1β) expression while significantly reducing levels glutathione downregulating acetylcholinesterase. The PET-NPs caused significant changes histopathology tissue, there demonstrable rise immunostaining IL-1β glial fibrillary acidic proteins. Consequently, effectively alleviated negative consequences PET-NaPs. Therefore, possesses capacity mitigate neurotoxic induced by

Language: Английский

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Chitosan-Functionalization Graphene Oxide for Immobilizing Gold Nanoparticles: Application of Its Catalytic Performance in the Reduction of Methylene Blue and Methyl Orange and Investigation of Its Anti-lung Cancer Effects

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Language: Английский

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Redox modulatory role of DJ-1 in Parkinson’s disease

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: March 30, 2025

Language: Английский

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Neuroprotective Effects of Peanut Skin Extract Against Oxidative Injury in HT-22 Neuronal Cells

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 544 - 544

Published: April 8, 2025

Background: Oxidative stress is a key therapeutic target in neurological disorders. As processing wastes from the peanut industry, skins are great sources of antioxidants and possess potential neuroprotection. Methods: We prepared skin extract (PSE) investigated its protective effects against tert-butyl hydroperoxide (t-BHP)-induced oxidative injury HT-22 neuronal cells. Results: PSE was rich phenolic compounds (123.90 ± 0.46 mg GAE/g), comprising flavonoids (75.97 0.23 RE/g) proanthocyanidins (53.34 1.58 PE/g), displayed potent radical scavenging activities chemical-based assays. In cells, pretreatment restored balance endogenous antioxidant defense disrupted by t-BHP, as evidenced significant reductions ROS generation lipid peroxidation levels, along with enhanced antioxidants. Specifically, 25 μg/mL reduced levels 53.03%, decreased MDA content 78.82%, superoxide dismutase (SOD) activity 12.42%, improved ratio glutathione (GSH) to oxidized (GSSG) 80.34% compared t-BHP group. Furthermore, rescued mitochondrial membrane collapse, inhibited cytochrome c (Cyt.c) release, prevented subsequent apoptotic death. Notably, neuroprotective efficacy comparable that edaravone, an approved drug. Mechanistic investigations combining network pharmacology experimental validation revealed PI3K/Akt/Nrf2 signaling pathway played pivotal role mediating PSE. Compared t-BHP-treated µg/mL significantly upregulated PI3K/Akt phosphorylation, expression Nrf2, downstream proteins heme oxygenase-1 (HO-1) NAD(P)H dehydrogenase quinone 1 (NQO1). Conclusions: Collectively, these findings demonstrate natural agent oxidative-related

Language: Английский

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Enhancing neurological disease diagnostics: fusion of deep transfer learning with optimization algorithm for acute brain stroke prediction using facial images

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 10, 2025

Language: Английский

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Neuroadaptation in neurodegenerative diseases: compensatory mechanisms and therapeutic approaches

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111375 - 111375

Published: April 1, 2025

Language: Английский

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Edaravone dexborneol protected neurological function by targeting NRF2/ARE and NF-κB/AIM2 pathways in cerebral ischemia/reperfusion injury

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Background Edaravone dexborneol (Eda-Dex), a promising neuroprotectant composed of edaravone and (+)-borneol, has been clinically applied in stroke treatment. However, the mechanism action Eda-Dex remains unclear. Methods A rat model cerebral ischemia/reperfusion injury (CIRI) was created through middle artery occlusion. Neurological scoring, TTC staining, laser speckle imaging were used to assess neurological deficits, infarct size blood flow (CBF). Behavioral tests, including open field test, elevated plus maze, novel object recognition conducted animal behavior. Western blotting ELISA employed levels expression components NRF2/ARE NF-κB/AIM2 pathways specific cytokines. The oxidative stress markers analyzed via commercially available kits. HE Nissl immunohistochemistry pathological alterations brain. Results dramatically reduced deficit score size, increased CBF, attenuated anxiety-like behavior improved cognitive function CIRI rats. significantly relieved inflammatory response it upregulated NRF2, NQO1, HO-1, SLC7A11 downregulated NF-κB, AIM2, ASC caspase 1 infarcted Moreover, clearly damage, rescued neurons, activation microglia astrocytes. Conclusions results this study confirm that exerts neuroprotective effects by synergistically inhibiting inflammation

Language: Английский

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Ketorolac-Based Ester Derivatives as Promising Hits for Malignant Glioma: Synthesis, Brain Cancer Activity, Molecular Docking, Dynamic Simulation and DFT Investigation

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141128 - 141128

Published: Dec. 1, 2024

Language: Английский

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