Assessing the therapeutic potential of KK14 peptide derived from Cyprinus Carpio in reducing intercellular ROS levels in oxidative Stress‐Induced In vivo zebrafish larvae model: An integrated bioinformatics, antioxidant, and neuroprotective analysis

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(11)

Published: Oct. 28, 2024

Abstract H 2 O is a significant reactive oxygen species (ROS) that hinders redox‐mediated processes and contributes to oxidative stress neurodegenerative disorders. Oxidative causes impairment of cell macromolecules, which results in dysfunction neurodegeneration. Alzheimer's disease other diseases are serious conditions linked stress. Antioxidant treatment approaches novel successful strategy for decreasing neurodegeneration reducing This study explored the antioxidant neuroprotective characteristics KK14 peptide synthesized from LEAP 2B (liver‐expressed antimicrobial peptide‐2B) derived Cyprinus carpio L. Molecular docking studies were used assess properties KK14. The at concentrations 5–45 μM was examined by using vitro vivo assessment. Analysis done on developmental potential ‐exposed zebrafish larvae showed Nonlethal deformities. improves enzyme activity like catalase superoxide dismutase. Furthermore, it reduces neuronal damage lowering lipid peroxidation nitric oxide generation while increasing acetylcholinesterase activity. It improved changes swimming behavior cognitive produced exposure . To further substantiate KK14, intracellular ROS levels assessed. led reduction diminished peroxidation. has upregulated genes against Overall, this proved strong suggesting its as therapeutic option neurological disorders caused

Language: Английский

A cognitive few-shot learning for medical diagnosis: A case study on cleft lip and palate and Parkinson’s disease

Expert Systems with Applications, Journal Year: 2024, Volume and Issue: 262, P. 125713 - 125713

Published: Nov. 4, 2024

Language: Английский

Exosomes in infectious diseases: insights into leishmaniasis pathogenesis, immune modulation, and therapeutic potential

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Language: Английский