Polycyclic aromatic compounds, Journal Year: 2023, Volume and Issue: 44(5), P. 3419 - 3441
Published: July 30, 2023
AbstractCurcumin longa (Turmeric) contains an extremely strong phytochemical called curcumin, which has various medicinal and industrial benefits, including anti-inflammatory anti-cancer effects, textile dyeing, food beverage colorants. However, due to its poor bioavailability low aqueous solubility, it is unstable. These physiochemical properties limit curcumin's clinical application. In order solve this problem, scientists recently made new PAMAM dendrimers of the zero, first, second generations conjugated with curcumin benzophenone, a water-soluble secondary metabolite. Here, we use topological indices examine these novel dendrimers. Adriatic indices, are subclass can be used measure how arrangement atoms in chemical structure affects most important physical properties. study, parameters aforementioned dendrimer, density, retention duration, enthalpy, lipophilicity, calculated analyzed based on 16 distinct adriatic indices. Enhanced near future likely bring promising natural product forefront therapeutic agents for treatment human diseases.Keywords: Topological indicesadriatic indicescurcuminbenzophenonePAMAM AcknowledgmentsI would like convey my gratitude institution VIT, Chennai thank our colleagues who stimulated protracted deep-rooted awareness into study. This research received no external funding.Disclosure statementNo potential conflict interest was reported by author(s).
Language: Английский