Suspect screening of per-and polyfluoroalkyl substances in paper by selective and non-selective extraction with UHPLC-Q orbitrap MS DOI Creative Commons
Nondumiso N. Mofokeng, Lawrence Mzukisi Madikizela,

Ineke Tiggelman

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 363, P. 142904 - 142904

Published: July 20, 2024

Non-targeted analysis and suspect screening of per- polyfluoroalkyl substances (PFAS) in various matrices have gained traction with advancements accurate mass analytical instruments. This study employed ultra-high performance liquid chromatography coupled to quadrupole orbitrap high-resolution spectrometry for PFAS paper grades used the recycling chain. The samples were prepared using two extraction techniques; selective accelerated solvent weak anionic exchange solid-phase non-selective ultrasonic-assisted extraction. A protocol was established tentatively identify suspected against spectral databases a systematic approach peak filtering study-specific thresholds reporting, linked confidence level. possible prevalence previously unreported several materials across collection sites chain inferred by common detection short-chain ketones diketones identified 41 unique PFAS, 3 both pre-treatment techniques. sample techniques highlighted significance endeavours. Further, it showed importance understanding acquisition mechanisms where data-dependent triggered fragmentation certain compounds, not others. indicated that there additional studies required investigate their abundance, persistence, bioaccumulation toxicity, relation functional groups carbon chains.

Language: Английский

Occurrence, fate, and remediation for per-and polyfluoroalkyl substances (PFAS) in sewage sludge: A comprehensive review DOI Creative Commons
Ting Zhou, Xuan Li, Huan Liu

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 466, P. 133637 - 133637

Published: Jan. 29, 2024

Addressing per-and polyfluoroalkyl substances (PFAS) contamination is an urgent environmental concern. While most research has focused on PFAS in water matrices, comparatively little attention been given to sludge, a significant by-product of wastewater treatment. This critical review presents the latest information emission sources, global distribution, international regulations, analytical methods, and remediation technologies for sludge biosolids from treatment plants. concentrations matrices are typically hundreds ng/g dry weight (dw) developed countries but rarely reported developing least-developed due limited capability. In comparison samples, efficient extraction cleaning procedures crucial detection samples. regulations have mainly soil reuse, only two set limits or with maximum 100 dw major PFAS. Biological using microbes enzymes present considered as having high potential remediation, they eco-friendly, low-cost, promising. By contrast, physical/chemical methods either energy-intensive linked further challenges disposal. The findings this deepen our comprehension guided future recommendations.

Language: Английский

Citations

55
A systematic review for non-targeted analysis of per- and polyfluoroalkyl substances (PFAS) DOI Creative Commons
David Megson, Pennante Bruce-Vanderpuije, Ifeoluwa Idowu

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 960, P. 178240 - 178240

Published: Jan. 1, 2025

This review follows the PRISMA guidelines to provide a systematic of 115 peer reviewed articles that used non-targeted analysis (NTA) methods detect per- and polyfluoroalkylated substances (PFAS). literature highlights significant positive impact NTA in understanding PFAS environment. Within geographical bias exists, with most studies (∼60 %) conducted United States China. Future other regions (such as South America Africa) are needed gain more global understanding. More research is required marine environments atmosphere, current focus mainly on freshwater, groundwater, soil, sediments. The majority measuring environment, rather than commercial products (with exception AFFF). Non-lethal blood sampling has been successful for humans wildlife, but additional biomonitoring exposed cohorts understand health risks biotransformation pathways. mostly use liquid chromatography negative ionisation, which biases towards detection specific PFAS. Despite improvements data reporting quality assurance control (QA/QC) procedures, factors such false rates often overlooked, many workflows remain highly subjective. Perfluoroalkyl carboxylic acids (PFCAs) perfluoroalkyl sulfonic (PFSAs) detected classes, identified over 80 % studies, common routine monitoring. However, our >1000 from total 382 different 300 classes found fewer 5 studies. variety present limitations relying solely targeted methods. monitoring programs regulations would benefit considering comprehensive information

Language: Английский

Citations

6
Phytoremediation of perfluoroalkyl and polyfluoroalkyl substances (PFAS): Insights on plant uptake, omics analysis, contaminant detection and biomass disposal DOI
Davide Marzi,

Francesco Valente,

Sophia Luche

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 959, P. 178323 - 178323

Published: Jan. 1, 2025

Language: Английский

Citations

1
Transforming PFAS management: A critical review of machine learning applications for enhanced monitoring and treatment DOI
Md Hasan-Ur Rahman,

Rabbi Sikder,

Tanvir Ahamed Tonmoy

et al.

Journal of Water Process Engineering, Journal Year: 2025, Volume and Issue: 70, P. 106941 - 106941

Published: Jan. 15, 2025

Language: Английский

Citations

1
Non-targeted analysis reveals hundreds of per- and polyfluoroalkyl substances (PFAS) in UK freshwater in the vicinity of a fluorochemical plant DOI Creative Commons
David Megson, Daniel Niepsch,

Jonathan Spencer

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 367, P. 143645 - 143645

Published: Nov. 1, 2024

There are now over 7 million recognised per- and polyfluoroalkyl substances (PFAS), however the majority of routine monitoring programmes policy decisions based on just a handful these. is need for shift towards gaining better understanding total PFAS present in sample rather than relying targeted analysis alone. Total methods help us to understand if missing mass PFAS, but they do not identify which missing. Non-targeted fill this knowledge gap by using high resolution spectrometry sample. In manuscript we use complimentary non-targeted (NTA) detect hundreds five freshwater samples obtained from Northwest UK. Targeted revealed PFOA at maximum concentration 12,100 ng L

Language: Английский

Citations

4
Recent advances in the application of magnetic materials for the management of perfluoroalkyl substances in aqueous phases DOI
Kyeong Hwan Kang, Md Saifuddin, Kangmin Chon

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 352, P. 141522 - 141522

Published: Feb. 22, 2024

Language: Английский

Citations

3
Eutectic Solvent Mixtures in Environmental Contaminants Analysis: A Review on Current Trends and Future Perspectives DOI Creative Commons

Andrea Schincaglia,

Alberto Cavazzini, Luisa Pasti

et al.

Green Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 100220 - 100220

Published: Feb. 1, 2025

Language: Английский

Citations

0
A systematic review of methods for the analysis of total per- and polyfluoroalkyl substances (PFAS) DOI Creative Commons
Ifeoluwa Idowu, Okon Dominic Ekpe, David Megson

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 967, P. 178644 - 178644

Published: Feb. 12, 2025

This manuscript systematically reviews 156 peer-reviewed articles on methods for estimating total per- and polyfluoroalkyl substances (PFAS), following preferred reporting items systematic meta-analyses (PRISMA) guidelines. Direct indirect of PFAS include targeted analysis, fluorine (TF), organic (TOF), extractable (EOF), absorbable (AOF), oxidizable precursor (TOP) assay. Combustion ion chromatography (CIC) was the most utilized method (>50%), followed by particle-induced gamma-ray emission (PIGE, 9%) high-resolution-continuum source graphite furnace molecular absorption spectrometry (HR-CS-GFMAS, 6%). Techniques like instrumental neutron activation analysis (INAA) nuclear magnetic resonance (NMR) were less common. A geographic bias evident, with 69% studies from US (33%), Sweden (12%), China Germany (11%). Most research environmental samples (water, soil, sediments), while significant data gaps noted in South America, Africa, atmospheric PFAS. Challenges inter-laboratory comparisons arise inconsistent units (e.g., mg/L, μg/m3, %, etc.). About 75% involved pre-treatment solvent extraction, sorbents), 25% did not. detection limit observed concentrations varied widely, low water (ng/L) to higher levels biota, products (mg/L). Limitations contradictory results when complementary techniques are applied same sample, potentially leading over- or under-estimation. Across studies, a substantial fraction TF remains unaccounted for, highlighting need non-targeted screening (NTS) identify unknown (UPFAS UOPFAS). Bridging these is critical advancing risk assessment.

Language: Английский

Citations

0
Annotating DHA Metabolites Interfering with the Quantification of Emerging Perfluoroalkyl Ether Carboxylic Acids DOI

Yuyan Ji,

Yitao Pan, Jean‐Marie Galano

et al.

Environmental Science & Technology Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Quantitative analyses of per- and polyfluoroalkyl substances (PFAS) commonly rely on low-resolution targeted tandem mass spectrometry (MS/MS) due to its high sensitivity relatively low operational threshold. Perfluoro-3,5,7,9-butaoxadecanoic acid (PFO4DA), an important constituent the perfluoropolyether carboxylic (PFECA) family, has been widely detected in biotic abiotic matrices. Nevertheless, marked interference observed MS/MS transition for PFO4DA (377 > 85) biological samples, particularly aquatic organisms, resulting substantial overestimation concentrations, reaching up 66 ng/g. In this study, nontargeted molecular networking strategies, combined with spectral simulation tools SIRIUS QCxMS, were applied identify source interference, which was confirmed as oxygenated metabolite docosahexaenoic (DHA) based fragmentation patterns matching reference standards. The study further clarified that fatty acids generated fragment ion [C4H5O2]− (85.0296 Da), overlapped [CF3O]− (84.9907 Da) PFECA compounds under conditions, causing signal interference. Analysis river water fish samples revealed led a 24-fold bioaccumulation organisms. These findings are essential improving selectivity environmental exposure assessments compounds.

Language: Английский

Citations

0
Per- and Poly-fluoroalkyl Substances as Forever Chemicals in Drinking Water: Unraveling the Nexus with Obesity and Endocrine Disruption – A Mini Review DOI Creative Commons

Hoda Pezeshki,

Saeed Rajabi, Majid Hashemi

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42782 - e42782

Published: Feb. 1, 2025

Per- and Poly-fluoroalkyl substances (PFASs) are among the that have been widely employed across world due to their distinct features. These chemicals' great stability in environment capacity be released from consumer goods demonstrated existence all matrices. Additionally, world's attention has drawn these substances' direct relation human health recent years. This research aimed unravel nexus of PFASs with obesity endocrine disruption as a comprehensive review. Studies shown drinking water is primary way which humans exposed PFASs. As result, it become difficult determine how contaminated compounds impacts affect health. Through various routes, metabolic processes, possible effects on hypothalamus-pituitary-thyroid axis, chemicals increase incidence obesity, particularly during crucial growth phases. Another negative impact glands' function, for controlling body's physiological functions. leads alterations hormone production. The exposure include secondary hyperparathyroidism, non-alcoholic fatty liver, diabetes, cardiovascular illnesses, reproductive abnormalities, infertility. Because characteristics, including propensity propagate through food chain, accumulate biomagnify, ultimately pose threat life, replace remove chemicals.

Language: Английский

Citations

0