Exosomes: A Fluid Biopsy Source for Clinical Interventions of Noncommunicable Diseases Treatment: A Review DOI Creative Commons
Mohanram Narayanan,

Mani Ayyandurai,

V. Rajinikanth

et al.

Dubai Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Introduction: The beginning of exosome biosynthesis is marked by the emergence initial endosomes through inward splitting plasma cell membrane. This process facilitated endosomal categorization complex essential for transport, which also involved in production different extracellular vesicles. Exosomes are naturally occurring nanosized vesicles found all bodily fluids and can be successfully extracted from preserved biological materials, while maintaining their structural integrity. Methods: articles published recently high-quality journals (Science Direct, Springer, Institute Electrical Electronics Engineers (IEEE), Taylor & Francis) indexed various indexing sources such as Scopus, Web Science, PubMed, Google Scholar, so on were collected using keywords fluid biopsy (FB) exosomes, endosomes, noncommunicable diseases (NCDs) treatment, new biomarkers, treatment. Discussion: In recent years, exosomes have emerged an exciting option “FB” that has demonstrated significant potential areas noninvasive medical testing, predictions, well tracking responses to therapy diseases. Nevertheless, specific constraints need addressed expand application exosome-based FB a widely accepted reliable testing method typical facilities. Conclusion: review provides comprehensive overview our present understanding diagnosing, predicting outcomes, treatment NCDs. It discusses main constraints, innovations technology, future possibilities this

Language: Английский

Urinary extracellular vesicle-derived miR-126-3p predicts lymph node invasion in patients with high-risk prostate cancer DOI Creative Commons
Liang Dong, Cong Hu,

Zehua Ma

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(7)

Published: June 5, 2024

Abstract To investigate extracellular vesicles (EVs), biomarkers for predicting lymph node invasion (LNI) in patients with high-risk prostate cancer (HRPCa), plasma, and/or urine samples were prospectively collected from 45 (PCa) and five benign prostatic hyperplasia (BPH). Small RNA sequencing was performed to identify miRNAs the EVs. All PCa underwent radical prostatectomy extended pelvic dissection. Differentially expressed identified without pathologically-verified LNI. The candidate validated low-risk (LRPCa) BPH. Four miRNA species (e.g., miR-126-3p) three miR-27a-3p) more abundant urinary plasma EVs, respectively, of PCa. None these shared between miR-126-3p significantly HR LNI than those ( P = 0.018). EVs HRPCa LRPCa 0.017) BPH 0.011). In conclusion, EVs-derived may serve as a good biomarker HRPCa.

Language: Английский

Citations

5
Metabolites in Serum Small Extracellular Vesicles Instead of Small Extracellular Vesicles‐depleted Serum Have Better Diagnostic Value for Cancers at Early Stage DOI Open Access
Yun Su, Zehong Peng, Yuning Wang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Serum is one of the most commonly used biofluids for biomarker exploration. Some studies examine serum directly, while others focus on specific components like small extracellular vesicles (sEVs), which are lipid-bilayer encapsulated particles carrying a variety molecular cargos. However, diagnostic value sEVs versus sEVs-depleted fractions (EV-free serum) early cancer detection unclear. In study, size exclusion chromatography (SEC) employed to separate from prostate (PCa) suspects into sEVs-enriched (EV) and EV-free serum. Metabolic fingerprints obtained using ferric nanoparticle-assisted laser ablation/ionization mass spectroscopy (FeNPALDI-MS), revealing heterogeneity in metabolic composition. Eleven key metabolites identified EV two that differentiate PCa benign prostatic hyperplasia. The showed higher patients with an area under curve (AUC) 0.76, p < 0.05 improved efficacy when combined prostate-specific antigen (PSA, AUC = 0.85).

Language: Английский

Citations

0
Extracellular vesicles in uveal melanoma - biological roles and diagnostic value DOI Creative Commons
Ornella Urzì, Roger Olofsson Bagge, Rossella Crescitelli

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217531 - 217531

Published: Feb. 1, 2025

Language: Английский

Citations

0
Role of Triple‐Negative Breast Cancer‐Derived Extracellular Vesicles in Metastasis: Implications for Therapeutics and Biomarker Development DOI Creative Commons

X. Wan,

Liqi Yang,

Linjun Wu

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(5)

Published: March 1, 2025

Triple-negative breast cancer (TNBC) is a highly aggressive form of with poor prognosis and high mortality. The chemotherapeutic regimen remains the predominant treatment modality for TNBC in current clinical practice. However, chemotherapy resistance significantly complicates development an effective regimen. Furthermore, immunosuppressive microenvironment contributes to enhanced tumour aggressiveness. Consequently, understanding its mechanisms progression finding therapeutic interventions crucial. Recent evidence has identified extracellular vesicles (EVs) as key mediators cell-to-cell communication immune regulation. In view remarkable ability EVs transfer active molecules, such proteins nucleic acids, from parental recipient cells, they are regarded promising biomarker novel drug delivery system. this review, we provide overview how derived cells play role regulating progression. We also discuss potential regulation their application strategies markers TNBC. knowledge gained studying EV-mediated could lead targeted therapies improve patient outcomes.

Language: Английский

Citations

0
Extracellular vesicles in endometrial-related diseases: role, potential and challenges DOI Creative Commons
Zilu Wang, Li Feng, Wenqiong Liu

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19041 - e19041

Published: March 12, 2025

Endometrial dysfunction underlies many common gynecologic disorders, such as endometriosis, endometrial cancer, intrauterine adhesions, and endometritis, which affect women around the world. Extracellular vesicles play an important role in pathophysiologic process of endometrial-related diseases. are released by cells, usually act a form intercellular communication, affecting biological processes fibrosis, angiogenesis, cell proliferation, inflammatory responses transferring their own proteins, lipids, RNA transcripts, DNA for messaging, key physiological dynamic homeostasis disease development. This review combines studies last decade, using sub-description method to introduce application different sources extracellular diagnosis treatment related diseases, discusses challenges faced diagnostic therapeutic endometriosis-related with aim contributing our understanding mechanism action roles, so provide reference development well prognosis treatment.

Language: Английский

Citations

0
New Challenges and Opportunities: Extracellular Vesicles in Biological and Biochemical Processes DOI Open Access
Ilaria Giusti, Celeste Caruso Bavisotto

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3395 - 3395

Published: April 4, 2025

Cell-to-cell communication plays a crucial role in many processes, both physiological and pathological assets [...].

Language: Английский

Citations

0
Bridging Laboratory Innovation to Translational Research and Commercialization of Extracellular Vesicle Isolation and Detection DOI
Hyun‐Kyung Woo, Yoonho Nam, Hyun Gyu Park

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: unknown, P. 117475 - 117475

Published: April 1, 2025

Language: Английский

Citations

0
Proteome of human glioblastoma and meningioma tissue small extracellular vesicles DOI Open Access
Huaqi Su, Adityas Purnianto, Andrew H. Kaye

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 16, 2024

Small extracellular vesicles have gained attention in neuroscience due to their role cell-to-cell communication and potential diagnostic therapeutic applications. Despite progress the field, there remains a gap our understanding of composition function with regards brain tumours. Previous studies primarily evaluated obtained from patient fluids or cell culture medium, rather than directly tumour tissue. Here we successfully isolated small surgical tissue biopsies glioblastomas meningiomas, marking, marking first report situ vesicle isolation The protein content was characterized using tandem mass spectrometric proteomics, revealing proteins exclusively detected enriched relative While study confirmed previously identified glioblastoma meningioma various sources, it also novel pathways associated these types. This underscores benefit analysing derived for insights into biology highlights need further research comparing types grades

Language: Английский

Citations

1
Exosomes: A Fluid Biopsy Source for Clinical Interventions of Noncommunicable Diseases Treatment: A Review DOI Creative Commons
Mohanram Narayanan,

Mani Ayyandurai,

V. Rajinikanth

et al.

Dubai Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Introduction: The beginning of exosome biosynthesis is marked by the emergence initial endosomes through inward splitting plasma cell membrane. This process facilitated endosomal categorization complex essential for transport, which also involved in production different extracellular vesicles. Exosomes are naturally occurring nanosized vesicles found all bodily fluids and can be successfully extracted from preserved biological materials, while maintaining their structural integrity. Methods: articles published recently high-quality journals (Science Direct, Springer, Institute Electrical Electronics Engineers (IEEE), Taylor & Francis) indexed various indexing sources such as Scopus, Web Science, PubMed, Google Scholar, so on were collected using keywords fluid biopsy (FB) exosomes, endosomes, noncommunicable diseases (NCDs) treatment, new biomarkers, treatment. Discussion: In recent years, exosomes have emerged an exciting option “FB” that has demonstrated significant potential areas noninvasive medical testing, predictions, well tracking responses to therapy diseases. Nevertheless, specific constraints need addressed expand application exosome-based FB a widely accepted reliable testing method typical facilities. Conclusion: review provides comprehensive overview our present understanding diagnosing, predicting outcomes, treatment NCDs. It discusses main constraints, innovations technology, future possibilities this

Language: Английский

Citations

0