Edible Berries- An Update on Nutritional Composition and Health Benefits- Part III

Current Nutrition Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 3, 2025

Language: Английский

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Hormonal Gut–Brain Signaling for the Treatment of Obesity

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3384 - 3384

Published: Feb. 8, 2023

The brain, particularly the hypothalamus and brainstem, monitors integrates circulating metabolic signals, including gut hormones. Gut–brain communication is also mediated by vagus nerve, which transmits various gut-derived signals. Recent advances in our understanding of molecular gut–brain promote development next-generation anti-obesity medications that can safely achieve substantial lasting weight loss comparable to surgery. Herein, we comprehensively review current knowledge about central regulation energy homeostasis, hormones involved food intake, clinical data on how these have been applied drugs. Insight into axis may provide new therapeutic perspectives for treatment obesity diabetes.

Language: Английский

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An Overview of Nanoemulgels for Bioavailability Enhancement in Inflammatory Conditions via Topical Delivery

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1187 - 1187

Published: April 7, 2023

The anti-inflammatory drugs that are generally available possess the disadvantage of hydrophobicity, which leads to poor permeability and erratic bioavailability. Nanoemulgels (NEGs) novel drug delivery systems aim improve solubility across biological membrane. nano-sized droplets in nanoemulsion enhance permeation formulation, along with surfactants co-surfactants act as enhancers can further permeability. hydrogel component NEG helps increase viscosity spreadability making it ideal for topical application. Moreover, oils have properties, such eucalyptus oil, emu oil clove used phases preparation nanoemulsion, shows a synergistic effect active moiety enhances its overall therapeutic profile. This creation hydrophobic enhanced pharmacokinetic pharmacodynamic simultaneously avoid systemic side effects individuals external inflammatory disorders. nanoemulsion’s effective spreadability, ease application, non-invasive administration, subsequent ability achieve patient compliance make more suitable application combat many disorders, dermatitis, psoriasis, rheumatoid arthritis, osteoarthritis so on. Although large-scale practical is limited due problems regarding scalability thermodynamic instability, arise from use high-energy approaches during production these be resolved by advancement an alternative nanoemulsification technique. Considering potential advantages long-term benefits NEGs, authors this paper compiled review elaborates significance utilizing nanoemulgels system drugs.

Language: Английский

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Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(6), P. 904 - 904

Published: June 20, 2023

The gut microbiota play a crucial role in maintaining host health and have significant impact on human disease. In this study, we investigated the alpha diversity of COVID-19 patients analyzed variants, antibiotic treatment, type 2 diabetes (T2D), metformin therapy composition diversity. We used culture-based method to analyze calculated alpha-diversity using Shannon H' Simpson 1/D indices. collected clinical data, such as length hospital stay (LoS), C-reactive protein (CRP) levels, neutrophil-to-lymphocyte ratio. found that with T2D had significantly lower than those without T2D. Antibiotic use was associated reduction alpha-diversity, while an increase. did not find differences between Delta Omicron groups. stay, CRP NLR showed weak moderate correlations Our findings suggest diverse may benefit Interventions preserve or restore diversity, avoiding unnecessary use, promoting therapy, incorporating probiotics, improve patient outcomes.

Language: Английский

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Polyphenols from hickory nut reduce the occurrence of atherosclerosis in mice by improving intestinal microbiota and inhibiting trimethylamine N-oxide production

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155349 - 155349

Published: Jan. 9, 2024

Language: Английский

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