Aging and Disease,
Journal Year:
2013,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2013
Aging
is
characterized
by
progressive
multisystem
deterioration
driven
molecular
and
cellular
mechanisms
encapsulated
in
the
twelve
hallmarks
of
aging.
Green
tea
(GT),
derived
from
Camellia
sinensis,
has
garnered
significant
scientific
interest
due
to
its
rich
polyphenolic
composition,
particularly
epigallocatechin-3-gallate,
pleiotropic
health
benefits.
In
this
narrative
review,
we
explored
multifaceted
through
which
GT
may
mitigate
aging
hallmarks.
Evidence
vitro,
animal,
human
studies
shown
that
polyphenols
can
enhance
DNA
repair
pathways,
preserve
telomere
length,
modulate
epigenetic
markers,
improve
proteostasis
autophagic
flux,
regulate
nutrient-sensing
networks,
rejuvenate
mitochondrial
function.
Additionally,
exhibits
anti-inflammatory
properties
restore
a
physiological
gut
microbiota
composition.
Beyond
effects,
consumption
humans
been
associated
with
improved
cognitive
function,
cardiovascular
health,
muscle
preservation,
metabolic
regulation
populations.
Collectively,
these
findings
highlight
GT's
potential
as
naturally
occurring
geroscience
intervention
capable
addressing
interconnected
network
processes
more
comprehensively
than
single-target
pharmaceuticals.
Future
research
should
focus
on
optimizing
dosing
regimens,
exploring
synergies
other
anti-aging
strategies,
investigating
personalized
responses
interventions.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Aug. 1, 2024
Catechins,
a
class
of
phytochemicals
found
in
various
fruits
and
tea
leaves,
have
garnered
attention
for
their
diverse
health-promoting
properties,
including
potential
combating
neurodegenerative
diseases.
Among
these
catechins,
(-)-epigallocatechin-3-gallate
(EGCG),
the
most
abundant
polyphenol
green
tea,
has
emerged
as
promising
therapeutic
agent
due
to
its
potent
antioxidant
anti-inflammatory
effects.
Chronic
neuroinflammation
oxidative
stress
are
key
pathological
mechanisms
diseases
such
Alzheimer's
disease
(AD)
Parkinson's
(PD).
EGCG
neuroprotective
efficacy
scavenging
free
radicals,
reducing
attenuating
neuroinflammatory
processes.
This
review
discusses
molecular
EGCG's
anti-oxidative
chronic
neuroinflammation,
emphasizing
effects
on
autoimmune
responses,
neuroimmune
system
interactions,
focusing
related
AD
PD.
By
elucidating
action
impact
processes,
this
underscores
intervention
AD,
PD,
possibly
other
Overall,
emerges
natural
compound
stress,
offering
novel
avenues
strategies
treatment
disorders.
Nutritional Neuroscience,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 18
Published: Jan. 8, 2025
Objectives
This
review
examines
how
food
additives
impact
the
central
nervous
system
(CNS)
focusing
on
effects
of
sugars,
artificial
sweeteners,
colorings,
and
preservatives.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 4, 2025
Nutrition
and
immunity
have
emerged
as
active
research
areas
within
basic
nutrition
science,
representing
an
interdisciplinary
field
bridging
immunology.
While
traditional
immunology
focuses
on
the
immune
system's
defense
against
exogenous
substances,
explores
relationship
between
dietary
nutrients,
factors,
nutritional
status,
system
function.
Related
extends
further
to
examine
immune-mediated
effects
interventions
of
nutrients
homeostasis
diseases
1
.
Dietary
components
include
macronutrients
such
carbohydrates,
fats,
proteins,
micronutrients
zinc
(Zn)
iron
(Fe),
additives
flavonoids
polyphenolic
compounds.
The
promising
focus
has
been
raised
conduct
multidimensional
studies
investigate
immunomodulatory
functions
disease
intervention
various
2
It's
critical
elucidate
interactions
system,
well
intermediated
roles
in
both
health
disease.
identification
molecular
mechanisms
immunoregulatory
from
a
genetic
perspective
underpins
foundation
multidisciplinary
research,
improve
function
through
interventions,
ultimately
promoting
well-being.The
relies
exploration
gut
microbiota
context
immunity,
energy
metabolism,
systemic
which
could
systematically
secretion
metabolic
patterns
functional
like
along
with
their
3
For
example,
infant
are
expected
be
proposed
comprehensively
dynamic
changes
nutrient
human
milk
oligosaccharides
(HMOs)
probiotics
breast
across
different
stages
pregnancy,
elucidating
regulating
immunity.
Moreover,
bioactive
polyphenols
microbiota,
intestinal
homeostasis,
inflammation
intense
for
intervention.The
study
is
individual
differences
metabolism
plant
Focusing
neurodegeneration,
it
evaluate
non-nutritional
bioactivities
efficacy
chronic
interventions.
interaction
require
investigates
prebiotics
[4][5]
It
helpful
regulatory
maintaining
6
By
exploring
innate
adaptive
establishes
based
host
system.
clarifies
application
characteristics
specific
metabolites.
addressed
mediating
provides
systematic
analysis
immune-enhancing
effects,
offering
scientific
basis
data
support
dietary-based
regulation
immunity-based
precision
interventions.As
increased
concern
aging
related
dysbiosis,
it's
mediated
healthy
aging,
restore
[7][8]
drives
decline
multiple
systems
organs,
closely
inflammation,
repeated
infection,
age-related
elderly
individuals,
thus
delaying
essential
prevent
aging-related
contribute
9
Studies
found
that
varied
can
supplement
2'-fucosyllactose
(2'-FL),
significantly
alleviate
osteoporosis,
syndrome,
oxidative
stress
10
speculated
emphasize
mechanism
aging.
Anyhow,
important
extend
immunology,
results
about
provide
novel
strategies
effect.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1084 - 1084
Published: Jan. 27, 2025
In
this
work,
the
spectroscopy
of
epigallocatechin-3-gallate
(EGCG)
and
EGCG
bonded
to
1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol)
(sodium
salt)
(DPPG)
lipid
is
studied
both
experimentally
by
combining
high-resolution
vacuum
ultraviolet
(VUV)
photo-absorption
measurements
in
4.0–9.0
eV
energy
range
theoretical
calculations
using
density
functional
theory
(DFT)
methodology.
There
a
good
agreement
between
experimental
data,
inclusion
solvent
implicitly
explicitly
further
improves
agreement.
For
all
measured
absorption
bands
observed
VUV
spectra
water,
assignments
calculated
electronic
transitions
are
provided.
The
reveal
that
spectrum
DPPG-EGCG
has
an
intense
peak
around
150
nm,
which
accordance
with
it
assigned
electron
transfer
transition
from
resorcinol–pyrogallol
groups
different
smaller
molecule.
Finally,
increase
absorbance
can
be
associated
interaction
molecules.
