Exploring the impact of bioactive peptides from fermented Milk proteins: A review with emphasis on health implications and artificial intelligence integration

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144047 - 144047

Published: March 1, 2025

Language: Английский

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Neurobiological Mechanisms Underlying Psychological Dysfunction After Brain Injuries

Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 74 - 74

Published: Jan. 8, 2025

Despite the presentation of similar psychological symptoms, dysfunction secondary to brain injury exhibits markedly lower treatment efficacy compared injury-independent dysfunction. This gap remains evident, despite extensive research efforts. review integrates clinical and preclinical evidence provide a comprehensive overview neurobiological mechanisms underlying neuropsychological disorders, focusing on role key regions in emotional regulation across various forms injuries. It examines therapeutic interventions mechanistic targets, with primary goal identifying pathways for targeted treatments. The highlights promising avenues addressing injury-associated dysfunction, emphasizing Nrf2, neuropeptides, nonpharmacological therapies as multi-mechanistic capable modulating upstream mediators address complex interplay factors injury. Additionally, it identifies sexually dimorphic potential areas further exploration advocates detailed investigations into sex-specific patterns uncover additional contributors these disorders. Furthermore, underscores significant gaps, particularly inadequate consideration interactions among causal factors, environmental influences, individual susceptibilities. By this provides new insights calls paradigm shift toward more context-specific integrative approach developing following

Language: Английский

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Identification of bioaccessible and neuroprotective peptides from fermented casein hydrolysate

Journal of Dairy Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Fermented dairy products are beneficial to cognitive health. Fermentation-released bioactive peptides have the potential contribute neuroprotective effects of fermented products. However, known mostly prepared by enzymatic hydrolysis, and physicochemical screening food-derived functional typically overlooks interference biotransport after ingestion. Thus, we aimed identify from casein Lactobacillus delbrueckii ssp. bulgaricus provide more evidence supporting contribution fermentation-released peptides. We first screened bioaccessible hydrolysate simulating digestion, absorption, blood-brain barrier penetration using INFOGEST standardized protocols, human colon Caco-2 cells, brain microvascular endothelial hCMEC/D3 cells sequentially. Next, identified each stage nano-liquid chromatography tandem MS. The intersections were considered performed molecular docking against Kelch-like ECH-associated protein 1 (Keap1) predict validated predicted in BV2 microglial induced LPS. As a result, 1,971, 663, 276, 208 simulated at stage, 63 during fermentation, underwent transported via intestinal epithelial barrier. Among these peptides, 7 nontoxic small had relatively high affinities for Keap1 verified LPS-treated cells. found that Phe-Val-Ala-Pro-Phe-Pro-Glu (FE7) decreased nitric oxide, interleukin-1β, reactive oxygen species, lipid peroxidation levels 69.6%, 103.6%, 119.3%, 75.3%, respectively, In conclusion, FE7 could be promising peptide reducing neuroinflammation oxidative stress. Our approach provides feasible paradigm identifying

Language: Английский

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Interaction between serum inflammatory cytokines and brain-derived neurotrophic factor in cognitive function among first-episode schizophrenia patients

World Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 14(12), P. 1804 - 1814

Published: Nov. 27, 2024

BACKGROUND The pathogenesis of cognitive impairment in schizophrenia (SCZ) remains unclear. Accumulating studies showed that inflammatory-immune dysregulation and altered brain derived neurotrophic factor (BDNF) levels play a crucial role the psychopathology SCZ. However, their association with dysfunction first-episode SCZ patients has not been thoroughly investigated. AIM To explore interaction effects between function inflammatory cytokines BDNF METHODS current study is cross-sectional case-control investigation recruited 84 (SCZ group) 80 healthy controls (HCs at Huzhou Third Municipal Hospital August 2021 September 2023. ELISA was employed to measure serum interleukin (IL)-1β, IL-4, IL-6, IL-10, BDNF. Chinese brief test (C-BCT) positive negative syndrome scales were measured severity psychiatric symptoms. RESULTS Compared HC group, group exhibited elevated IL-1β IL-6 levels, decreased reduced C-BCT scores (all P < 0.001). In SCZ, negatively correlated (r = -0.324, 0.05). Information processing speed -0.315, 0.05) positively 0.290, 0.05); attention, working memory, comprehensive ability, executive Multiple regression analysis influenced dimensions (β -0.218 -0.327, all attention ability by -0.199 -0.261, ; 0.209, . CONCLUSION Our findings suggested interrelationships immune deficiency might underlie pathological mechanisms impairments patients.

Language: Английский

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Neuronutrition and Its Impact on Post-Stroke Neurorehabilitation: Modulating Plasticity Through Diet

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3705 - 3705

Published: Oct. 30, 2024

The recovery of neurological deficits after ischemic stroke largely depends on the brain's ability to reorganize its undamaged neuronal circuits and plasticity phenomena. consolidated evidence highlights involvement patient's impaired nutritional conditions in post-stroke unsatisfying rehabilitative outcomes. Standardized protocols usually applied hospitalized patients a rehabilitation setting aim mainly improve general health patients, do not consider high inter-individual variability neurorehabilitation outcomes, are sufficiently modifiable provide neuroprotective restorative dietary patterns that could promote functional during neurorehabilitation. Neuronutrition, an emergent scientific field neuroscience, represents valid model personalized approach, assuring, for each patient, nutrients having antioxidant anti-inflammatory properties, ensuring balanced microbiota composition, providing adequate neurotrophic support, essential improving plasticity, brain recovery, In present narrative review, we overview current knowledge neuronutrition as adjuvant strategy approach potentially effective neuroplasticity by counteracting or at least limiting oxidative/nitrosative stress, neuroinflammation, gut-brain axis disturbance.

Language: Английский

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Targeting gut-skin axis by food-derived active peptides ameliorate skin photoaging: A comprehensive review

Food & Function, Journal Year: 2024, Volume and Issue: 16(2), P. 366 - 388

Published: Dec. 3, 2024

Food-derived active peptides (FDAPs) are a class of that exert antioxidant, anti-inflammatory, anti-aging and other effects. In recent years, from natural foods have been reported to improve skin photoaging, but their mechanisms not summarized date. this review, we focused on the preparation FDAPs, function against photoaging through gastrointestinal barrier. Furthermore, latest progress FDAPs in prevention treatment via gut-skin axis is discussed. can be directly absorbed into tract enter tissues anti-photoaging effects; they also regulate gut microbiota, leading changes metabolites ameliorate light-induced aging. Future work needs focus delivery system clinical validation provide solutions or suggestions for improving photoaging.

Language: Английский

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