Exploring the Potential of Mitochondria‐Targeted Drug Delivery for Enhanced Breast Cancer Therapy

International Journal of Breast Cancer, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Breast cancer stands as the utmost prevalent malignancy in women, impacting epithelial tissue of breast and often displaying resistance to effective treatment due its diverse molecular histological features. Current modalities may exhibit decreasing efficacy over time can lead disease progression. The mitochondria, a crucial organelle responsible for cellular metabolism energy supply, stand highly sensitive both heat reactive oxygen species, presenting an assuring target photodynamic photothermal therapies (PTTs) cure. employment nanodrug carriers combination deliveries holds promise addressing challenges related drug degradation off-target toxicity. By circumventing reticuloendothelial system, nanocarriers bolster drug's bioavailability at intended site ensure controlled codelivery multiple drugs, thereby maintaining normal pharmacokinetic features regular pharmacodynamic characteristics different therapeutic mechanisms. precision this innovative technology have revolutionized delivery, substantially enhancing effectiveness. In pursuit targeting mitochondrial modifications cells, various such therapy (PDT), PTT, chemodynamic (CDT) been explored. These improved efficiency mitochondria-targeted their advantageous properties minimal toxicity, noninvasiveness, reduced resistance, safer profile. Our review article provides exhaustive overview alterations environment BC, impact on BC development, potential targets treatment, nanotherapeutic approaches limitations these approaches.

Language: Английский

Neuroprotective potential of paddy rice: advancing nutritional and therapeutic strategies for brain health

Nutritional Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: April 28, 2025

This review examines the neuroprotective potential of paddy rice bioactive compounds, with a focus on antioxidant, anti-inflammatory, and neuroregenerative properties that may aid in preventing neurodegenerative diseases. Key compounds analyzed include tocotrienols, gamma-oryzanol, phenolic acids. We conducted comprehensive existing studies detailing mechanisms by which bioactives support brain health. These were examined for their effects oxidative stress reduction, neuroinflammation modulation, neurotransmitter regulation, neurogenesis promotion. Bioactives such as gamma-oryzanol ferulic acid found to decrease neuroinflammatory markers function. Research shows enhance neural resilience cognitive function, suggesting role managing disorders like Parkinson's Alzheimer's disease. While preclinical evidence underscores therapeutic promise bioactives, further clinical are needed confirm efficacy, establish optimal dosages, improve bioavailability. advocates advanced nutraceutical development using bridge findings applications.

Language: Английский