Protective Effect of Enterococcus faecium Against Alcohol-Induced Acute Liver Injury Via Extracellular Vesicles in Rats DOI
Yuanyuan Zhu, Xiaofang Zhang,

Wenhui Huang

et al.

Foodborne Pathogens and Disease, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

The beneficial effects of probiotics on alcohol-induced liver injury have been studied, but the mechanisms by which Enterococcus regulates function are still under investigation. In this study, we examined faecium (Efm) and E. faecium-derived extracellular vesicles (EfmEVs) to provide a protective effect against ethanol-induced in rats. We evaluated impact EfmEVs histological lesions, antioxidative function, alanine aminotransferase (ALT), aspartate (AST) activities, serum ALT, AST, blood alcohol concentration. results demonstrated that pretreatment with Efm significantly ameliorated injury. mitigated decline antioxidant indicators (malondialdehyde, superoxide dismutase, glutathione peroxidase. Additionally, reduced ALT activities serum, potentially lowering ethanol Further, functional studies three bioactive components (inactivated Efm, EfmEVs, EVs-free supernatants) from bacterial culture revealed EVs were primarily responsible for liver-protective effect. Moreover, secretion contributed overall Efm. summary, mediated injury, improving These findings suggest could serve as potential strategy alleviate acute

Language: Английский

Protective Effect of Enterococcus faecium Against Alcohol-Induced Acute Liver Injury Via Extracellular Vesicles in Rats DOI
Yuanyuan Zhu, Xiaofang Zhang,

Wenhui Huang

et al.

Foodborne Pathogens and Disease, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

The beneficial effects of probiotics on alcohol-induced liver injury have been studied, but the mechanisms by which Enterococcus regulates function are still under investigation. In this study, we examined faecium (Efm) and E. faecium-derived extracellular vesicles (EfmEVs) to provide a protective effect against ethanol-induced in rats. We evaluated impact EfmEVs histological lesions, antioxidative function, alanine aminotransferase (ALT), aspartate (AST) activities, serum ALT, AST, blood alcohol concentration. results demonstrated that pretreatment with Efm significantly ameliorated injury. mitigated decline antioxidant indicators (malondialdehyde, superoxide dismutase, glutathione peroxidase. Additionally, reduced ALT activities serum, potentially lowering ethanol Further, functional studies three bioactive components (inactivated Efm, EfmEVs, EVs-free supernatants) from bacterial culture revealed EVs were primarily responsible for liver-protective effect. Moreover, secretion contributed overall Efm. summary, mediated injury, improving These findings suggest could serve as potential strategy alleviate acute

Language: Английский

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