A quantitative weight-of-evidence review of preclinical studies examining the potential developmental and reproductive toxicity of acetaminophen DOI Creative Commons
Daniel G. Kougias, Michael D. Southall, Anthony R. Scialli

et al.

Critical Reviews in Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 48

Published: Feb. 21, 2025

We previously developed a quantitative weight-of-evidence (QWoE) framework using prespecified scoring criteria for preclinical acetaminophen data to characterize potential developmental neurotoxicity outcomes with considerations biological relevance of the response adverse and strength methods study design. The current analysis uses this reproductive toxicity (DART) following exposure acetaminophen. Two-hundred forty-two QWoE entries were documented from in vivo rodent studies identified 110 publications across five categories: DART endpoints context (1) periadolescent/adulthood (nonpregnancy) exposures; (2) pregnant female and, utero or other exposures, (3) anatomical abnormalities, (4) development, (5) physical development. A mean outcome score calculated 242 entries. Data analyzed our moderate quality showing no consistent evidence male rodents at therapeutic and/or non-systemically toxic doses. Similar results found individual context- outcome-related endpoint analyses as segregated by sex. Overall, on demonstrated effects development structure function system.

Language: Английский

A quantitative weight-of-evidence review of preclinical studies examining the potential developmental and reproductive toxicity of acetaminophen DOI Creative Commons
Daniel G. Kougias, Michael D. Southall, Anthony R. Scialli

et al.

Critical Reviews in Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 48

Published: Feb. 21, 2025

We previously developed a quantitative weight-of-evidence (QWoE) framework using prespecified scoring criteria for preclinical acetaminophen data to characterize potential developmental neurotoxicity outcomes with considerations biological relevance of the response adverse and strength methods study design. The current analysis uses this reproductive toxicity (DART) following exposure acetaminophen. Two-hundred forty-two QWoE entries were documented from in vivo rodent studies identified 110 publications across five categories: DART endpoints context (1) periadolescent/adulthood (nonpregnancy) exposures; (2) pregnant female and, utero or other exposures, (3) anatomical abnormalities, (4) development, (5) physical development. A mean outcome score calculated 242 entries. Data analyzed our moderate quality showing no consistent evidence male rodents at therapeutic and/or non-systemically toxic doses. Similar results found individual context- outcome-related endpoint analyses as segregated by sex. Overall, on demonstrated effects development structure function system.

Language: Английский

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