Anti-Aging Effects and Mechanisms of Cod Collagen Peptides (CCPs) in Caenorhabditis elegans DOI Creative Commons

Jiale Wei,

Junjie Zhang, Nan Ding

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(5), P. 150 - 150

Published: April 23, 2025

Given the growing interest in natural compounds for promoting healthy aging, this study aimed to investigate potential of cod collagen peptides (CCPs), a readily available marine resource, extend lifespan and improve health. Lifespan assays were performed on C. elegans treated with different concentrations CCPs. Furthermore, various stress resistance assays, including those evaluating oxidative thermal stress, conducted. To elucidate underlying mechanisms, gene expression analysis key aging-related genes was performed. The results demonstrated that treatment 25 mg/mL CCPs extended by 13.2%, increased body length width 14.8% 20.6%, respectively, enhanced head-swing body-bending frequencies 66.9% 80.4%. Lipofuscin content apoptosis reduced 45.9% 34.1%, respectively. also showed improved resistance, 90.7% increase glutathione peroxidase (GPX) activity, 147.4% (GSH) content. Transcriptomic anti-aging activity activating MAPK pathway inhibiting IIS pathway, which associated protein aggregation. It lipid synthesis regulated metabolism through fat-6 pathway. indicated could be employed as valuable ingredient food pharmaceutical fields.

Language: Английский

Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis DOI Creative Commons
Xuan-Ying Xin, Jing Zhou,

Gao-Ge Liu

et al.

npj Science of Food, Journal Year: 2025, Volume and Issue: 9(1)

Published: Jan. 2, 2025

To investigate the anti-inflammatory effects of collagen peptides, peptides from cod skin were prepared to assess their in vitro and vivo efficacy against ulcerative colitis. The results show that demonstrated by inhibiting secretion pro-inflammatory cytokines reducing oxidative stress vitro. In vivo, significantly reduced colonic tissue damage, modulated serum cytokine balance, increased expression tight junction proteins ZO-1, Occludin, Claudin-1 colon tissue, enhanced abundance beneficial bacteria while harmful bacteria, restored microbial balance. addition, ameliorated colitis phosphorylation NF-κB p65, IκBα p38 MAPK NF-κB/MAPK signaling pathway. Based on these findings, could serve as potential therapeutic agents for managing

Language: Английский

Citations

1
Anti-Aging Effects and Mechanisms of Cod Collagen Peptides (CCPs) in Caenorhabditis elegans DOI Creative Commons

Jiale Wei,

Junjie Zhang, Nan Ding

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(5), P. 150 - 150

Published: April 23, 2025

Given the growing interest in natural compounds for promoting healthy aging, this study aimed to investigate potential of cod collagen peptides (CCPs), a readily available marine resource, extend lifespan and improve health. Lifespan assays were performed on C. elegans treated with different concentrations CCPs. Furthermore, various stress resistance assays, including those evaluating oxidative thermal stress, conducted. To elucidate underlying mechanisms, gene expression analysis key aging-related genes was performed. The results demonstrated that treatment 25 mg/mL CCPs extended by 13.2%, increased body length width 14.8% 20.6%, respectively, enhanced head-swing body-bending frequencies 66.9% 80.4%. Lipofuscin content apoptosis reduced 45.9% 34.1%, respectively. also showed improved resistance, 90.7% increase glutathione peroxidase (GPX) activity, 147.4% (GSH) content. Transcriptomic anti-aging activity activating MAPK pathway inhibiting IIS pathway, which associated protein aggregation. It lipid synthesis regulated metabolism through fat-6 pathway. indicated could be employed as valuable ingredient food pharmaceutical fields.

Language: Английский

Citations

0