Carbon Trends, Journal Year: 2024, Volume and Issue: 16, P. 100394 - 100394
Published: Aug. 18, 2024
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2025, Volume and Issue: 218, P. 115522 - 115522
Published: Jan. 22, 2025
Language: Английский
Citations
1
Nano Materials Science, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
8
Discover Chemistry., Journal Year: 2024, Volume and Issue: 1(1)
Published: Oct. 25, 2024
Biosensor is a revolutionary diagnostic tool that harnesses the synergy of biology and technology to detect quantify target analytes, enabling real-time monitoring, early disease diagnosis, innovative applications. Recent advancements in biocompatible materials have brought about significant transformation development biosensors. These tools are essential modern healthcare diagnostics environmental monitoring. This article highlights crucial role enhancing performance safety next-generation Innovative substances such as graphene, hydrogels, nanocomposites been developed, significantly improving sensor functionality compatibility with biological systems. However, challenges associated deploying these include scalability, manufacturing processes, long-term stability. emphasizes transformative potential advancing biosensor technologies expanding their applications across various fields. Detailed analysis illustrates how contribute evolution biosensors, offering more precise, reliable, accessible diagnostics.
Language: Английский
Citations
4
Journal of Molecular Graphics and Modelling, Journal Year: 2025, Volume and Issue: 136, P. 108964 - 108964
Published: Feb. 1, 2025
Language: Английский
Citations
0
Nanoscale, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy characterized by limited treatment options and poor prognosis. Nanoparticle-based drug delivery systems have emerged as a promising strategy to enhance cancer therapy efficacy improving targeting, reducing toxicity, enabling multifunctional applications. This review highlights some key types of nanoparticles, including liposomes, polymeric metallic dendrimers, quantum dots, which could effectively improve the various drugs used in chemotherapy, radiotherapy, immunotherapy, offering more precise effective options. With ability stability overcome biological barriers, nanoparticle-based represent transformative for ESCC treatment. Despite challenges, such biocompatibility scalability, future holds great promise, particularly development personalized nanomedicine novel therapeutic approaches targeting tumor microenvironment. ongoing advancements, hold immense potential revolutionize patient outcomes.
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7323 - 7352
Published: July 1, 2024
Prior studies on magnetite (Fe
Language: Английский
Citations
3
Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)
Published: Aug. 28, 2024
Cancer has emerged as a significant threat to human health. Nucleic acid therapeutics regulate the gene expression process by introducing exogenous nucleic fragments, offering new possibilities for tumor remission and even cure. Their mechanism of action high specificity demonstrate great potential in cancer treatment. However, drugs face challenges such low stability limited ability cross physiological barriers vivo. To address these issues, various delivery vectors have been developed enhance facilitate precise targeted within body. In this review article, we primarily introduce structures principles commonly used therapy, well their cellular uptake intracellular transportation processes. We focus on employed drug delivery, highlighting research progress applications recent years. Furthermore, propose trends prospects carriers future.
Language: Английский
Citations
2
Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101215 - 101215
Published: Aug. 25, 2024
Extracellular protein coronas (exPCs), which have been identified in various biofluids, are recognized for their pivotal role mediating the interaction between nanoparticles and cytomembrane. However, it is still unclear whether exPCs can induce different levels of intracellular proteostasis, utmost importance preserving cellular function, eliciting distinct biological behaviors. To investigate this, two types exPC-coated iron oxide (IONPs) prepared used to influence on extracellular outcomes. The results demonstrate that formation promotes colloidal stability IONPs, discrepancies components exPCs, including opsonin, dysopsonin, lipoprotein, responsible disparities uptake endocytic pathways. Moreover, differential evolution during internalization leads autophagy glycolysis activities, be attributed altered depletion angiopoietin 1 coronas, ultimately impacts PI3K/AKT-mTOR signaling. These findings offer valuable insights into dynamic characteristics internalization, consequential implications metabolism activity, may facilitate comprehension PCs effects NPs expedite design application biomedical nanoparticles.
Language: Английский
Citations
2
MedComm, Journal Year: 2024, Volume and Issue: 5(11)
Published: Oct. 20, 2024
Abstract Cancer is a leading cause of morbidity and mortality worldwide, an increase in incidence estimated the next future, due to population aging, which requires development highly tolerable low‐toxicity cancer treatment strategies. The use nanotechnology tailor treatments according genetic immunophenotypic characteristics patient's tumor, allow its targeted release, can meet this need, improving efficacy minimizing side effects. Nanomedicine‐based approach for diagnosis rapidly evolving field. Several nanoformulations are currently clinical trials, some have been approved marketed. However, their large‐scale production still hindered by in‐depth debate involving ethics, intellectual property, safety health concerns, technical issues, costs. Here, we survey key approaches, with specific reference organ‐on chip technology, cutting‐edge tools, such as CRISPR/Cas9 genome editing, through nanosystems needs personalized diagnostics therapy patients. An update provided on nanopharmaceuticals marketed those undergoing trials. Finally, discuss emerging avenues field challenges be overcome transfer nano‐based precision oncology into daily life.
Language: Английский
Citations
2
Frontiers in Drug Delivery, Journal Year: 2024, Volume and Issue: 4
Published: March 4, 2024
A rational design of drug nanocarriers supported by in silico modelling tools can improve the efficacy nanosystem-based intravascular delivery (IVDD). Computational model development stems from vision replacing conventional (pre)clinical trials with advanced simulations and applies to more efficient for therapies. To establish a standardized framework preclinical trials, it is necessary include that each experimental stage trial respective nanocarrier system give accurate verifiable results. This review paper highlights status discusses stages physics-based multiscale should be developed, validated exploited address need an effective assessment IVDD.
Language: Английский
Citations
1