Cited by Epigallocatechin gallate and vancomycin loaded poly(vinyl)-pyrrolidone-gelatine nanofibers, Conceivable curative approach for wound healing

Targeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-κB signaling pathway after myocardial ischemia-reperfusion injury DOI

Wan-ting Meng,

Jing Zhu,

Ya-chao Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 1, 2024

Abstract Reperfusion therapy is critical for saving heart muscle after myocardial infarction, but the process of restoring blood flow can itself exacerbate injury to myocardium. This phenomenon known as ischemia-reperfusion (MIRI), which includes oxidative stress, inflammation, and further cell death. microRNA-146a (miR-146a) play a significant role in regulating immune response has been studied its potential impact on improvement function injury. However, delivery miR-146a specific efficient manner remains challenge extracellular RNAs are unstable rapidly degraded. Milk exosomes (MEs) have proposed ideal platform miRNA-based they protect miRNAs from RNase degradation. In this study, effects containing MEs (MEs-miR-146a) cardiac were examined rat model MIRI. To enhance targeting MEs-miR-146a site injury, ischemic myocardium-targeted peptide IMTP was modified onto surfaces, whether could exert better therapeutic by echocardiography, indicators levels inflammatory factors. Furthermore, expressions mediated NF-κB signaling pathway-related proteins detected western blotting qRT-PCR elucidate mechanisms. MiR-146 mimics successfully loaded into electroporation at square wave 1000 V voltage 0.1 ms pulse duration. be up-taken cardiomyocytes protected cells oxygen glucose deprivation/reperfusion induced damage vitro. Oral administration decreased tissue apoptosis expression factors improved The level myocardium tissues significantly increased MEs-miR-146a, higher than that group. addition, intravenous injection enhanced heart, function, reduced suppressed inflammation MIRI, more effective treatment. Moreover, protein IRAK1, TRAF6 p-p65. Therefore, exerted their anti-inflammatory effect inhibiting IRAK1/TRAF6/NF-κB pathway. Taken together, our findings suggested may promising strategy treatment MIRI with outcome modification peptide, expected applied clinical practice future.

Language: Английский

Citations

Extracellular Vesicles’ Role in Angiogenesis and Altering Angiogenic Signaling DOI

Maryam Ateeq,

Mark Broadwin, Frank W. Sellke

et al.

Medical Sciences, Journal Year: 2024, Volume and Issue: 12(1), P. 4 - 4

Published: Jan. 3, 2024

Angiogenesis, the process of new blood vessels formation from existing vasculature, plays a vital role in development, wound healing, and various pathophysiological conditions. In recent years, extracellular vesicles (EVs) have emerged as crucial mediators intercellular communication gained significant attention for their modulating angiogenic processes. This review explores multifaceted EVs angiogenesis capacity to modulate signaling pathways. Through comprehensive analysis vast body literature, this highlights potential utilizing therapeutic tools both physiological pathological purposes. A good understanding these concepts holds promise development novel interventions targeting angiogenesis-related disorders.

Language: Английский

Citations

Opportunities and challenges of engineered exosomes for diabetic wound healing DOI

Lin Shi,

Song Dawei,

Cong Meng

et al.

Giant, Journal Year: 2024, Volume and Issue: 18, P. 100251 - 100251

Published: March 6, 2024

The treatment of diabetic wounds is a major challenge faced by the medical system, and there growing interest in developing innovative therapies to accelerate wound healing. Regenerative medicine with cells has shown promising potential skin repair, regenerative properties primarily attributed paracrine effects secreted products, including exosomes. Compared cell-based approaches, using exosomes as cell-free therapy for chronic several advantages. Exosomes can regulate intercellular communication releasing their contents, mRNA, miRNA, lipids, proteins, which further promote are well explored biomedical application owing advantages such biocompatibility low immunogenicity. However, common method exosome administration through injection, but due rapid clearance rate body, maintaining necessary therapeutic concentration around challenging. Therefore, it develop new biocompatible scaffold carrier extracellular vesicles, allowing them sustain at non-healing sites continuously Engineered kinds modified internal treated molecules, surface decoration or delivered engineered platform. In addition, some researchers have processed exosomes, known decoration, delivery platforms. regular greater promoting this review, we summarize molecular mechanisms from different sources varying modifications Advantages limitations repair were also discussed. Finally, highlight challenges future development directions translating our knowledge into clinical practice.

Language: Английский

Citations

Healing the diabetic wound: Unlocking the secrets of genes and pathways DOI

Raj Kamal, Ankit Awasthi,

Mandeep Pundir

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 975, P. 176645 - 176645

Published: May 15, 2024

Language: Английский

Citations

Epigallocatechin gallate and vancomycin loaded poly(vinyl)-pyrrolidone-gelatine nanofibers, Conceivable curative approach for wound healing DOI

Jiang Ni,

Yanhua Chen, Lan Zhang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114506 - 114506

Published: Jan. 15, 2025

Language: Английский

Citations