Polyhedral Oligomeric Silsesquioxane‐Based Nanoparticles for Efficient Chemotherapy of Glioblastoma

Small, Journal Year: 2023, Volume and Issue: 19(18)

Published: Feb. 1, 2023

Abstract Glioblastoma (GBM) is the most common lethal brain tumor with dismal treatment outcomes and poor response to chemotherapy. As regulatory center of cytogenetics metabolism, chemotherapeutic molecules exert therapeutic effects in nucleus. Nanodrugs showing nuclear aggregation effect are expected eliminate fundamentally suppress cells. In this study, a nanodrug delivery system based on polyhedral oligomeric silsesquioxane (POSS) introduced deliver drugs into nuclei GBM cells, effectively enhancing efficacy The nanoparticles modified folic acid iRGD peptides improve their cell targeting uptake via receptor‐mediated endocytosis. Nuclear allows for direct drug temozolomide (TMZ) nuclei, resulting more significant DNA damage inhibition proliferation. Herein, TMZ‐loaded POSS can significantly survival GBM‐bearing mice. Therefore, may serve as promising drug‐loaded platform chemotherapy patients.

Language: Английский

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Nuclear Delivery of Nanoparticle-Based Drug Delivery Systems by Nuclear Localization Signals

Cells, Journal Year: 2023, Volume and Issue: 12(12), P. 1637 - 1637

Published: June 15, 2023

Nanomedicine 2.0 refers to the next generation of nanotechnology-based medical therapies and diagnostic tools. This field focuses on development more sophisticated precise nanoparticles (NPs) for targeted drug delivery, imaging, sensing. It has been established that nuclear delivery NP-loaded drugs can increase their therapeutic efficacy. To effectively direct NPs nucleus, attachment localization signals (NLSs) employed in many applications. In this review, we will provide an overview structure pore complexes (NPCs) classic import mechanism. Additionally, explore various nanoparticles, including synthesis, functionalization, loading release mechanisms, targeting strategies, potential Finally, highlight challenges associated with developing nucleus-targeted nanoparticle-based systems (NDDSs) insights into future NDDSs.

Language: Английский

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A pH/ROS dual-responsive system for effective chemoimmunotherapy against melanoma via remodeling tumor immune microenvironment

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 14(5), P. 2263 - 2280

Published: Dec. 16, 2023

Chemotherapeutics can induce immunogenic cell death (ICD) in tumor cells, offering new possibilities for cancer therapy. However, the efficiency of immune response generated is insufficient due to inhibitory nature microenvironment (TME). Here, we developed a pH/reactive oxygen species (ROS) dual-response system enhance chemoimmunotherapy melanoma. The productively accumulated tumors by specific binding phenylboronic acid (PBA) sialic acids (SA). nanoparticles (NPs) rapidly swelled and released quercetin (QUE) doxorubicin (DOX) upon stimulation

Language: Английский

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Nanodelivery System of Traditional Chinese Medicine Bioactive Compounds: Application in the Treatment of Prostate Cancer

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 155554 - 155554

Published: March 29, 2024

The long history of clinical experience in China have confirmed the effectiveness traditional Chinese medicine (TCM) treating prostate cancer (PCa). Until now, several bioactive compounds with anti-PCa potential, such as curcumin, gallic acid, and quercetin, been extracted from TCM. Recent studies shown that encapsulating these TCM into nano-delivery system enhanced their bioavailability improved ability to target PCa tumors.

Language: Английский

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pH/GSH dual-responsive nanoparticle for auto-amplified tumor therapy of breast cancer

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 10, 2024

Language: Английский

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