Nanoplasmonic sensing as a rapid and sensitive methodology to investigate tolvaptan loaded plant-derived nanovesicles and liposomes
Journal of Pharmaceutical and Biomedical Analysis Open,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100052 - 100052
Published: Jan. 1, 2025
Language: Английский
Inter-Tissue Communication Mechanisms via Exosomes and Their Implications in Metabolic Diseases: Opportunities for Pharmacological Regulation
Brenda Chimal-Vega,
No information about this author
Jesus Emanuel Maldonado-Arvizu,
No information about this author
Alicia Ávalos
No information about this author
et al.
Future Pharmacology,
Journal Year:
2025,
Volume and Issue:
5(1), P. 11 - 11
Published: March 6, 2025
Exosomes
can
transport
regulatory
biomolecules
and
are
mediators
of
cellular
signaling
among
metabolic
tissues
through
endocrine
mechanisms.
Understanding
the
pathways
processes
underlying
exosome-mediated
inter-tissue
communication
is
critical
for
elucidating
molecular
pathophysiology
diseases
such
as
obesity,
type
2
diabetes
mellitus
(T2DM),
cardiovascular
disorders.
Consequently,
these
mechanisms
represent
novel
promising
targets
pharmacological
regulation.
We
examined
current
knowledge
regarding
exosome
physiology,
interaction
with
target
tissues,
its
role
in
tissue
communication.
also
analyzed
secretory
profiles
exosomes
emphasizing
their
roles
adipose
tissue,
liver,
pancreas,
skeletal
muscle,
small
intestine,
while
discussing
association
diseases.
In
this
sense,
we
propose
exosomal
pentad
a
framework
highlighting
inter-organ
communication,
where
may
regulate
axis
involving
tissues.
This
model
aligns
ominous
octet
but
emphasizes
key
regulators
homeostasis
potential
therapeutic
targets.
The
treatment
emerges
area
pharmacologic
exploration.
For
instance,
strategies
that
prevent
binding
or
expression
cargo
molecules
miRNAs
could
be
designed,
using
antagomiRs
nanoparticles.
Additionally,
integrins
like
αvβ5
on
membrane
blocked
monoclonal
antibodies
engineered
targeted
delivery
molecules.
Exosomes,
regulation,
hold
to
design
precise
molecular-level
therapies
minimizing
systemic
side
effects.
Language: Английский
Exploring the anti-colon cancer potential of febuxostat-based mixed metal complexes with 2,2′-bipyridine: MTT assay, toxicity evaluation, prediction profiles, and computational studies
Inorganic Chemistry Communications,
Journal Year:
2025,
Volume and Issue:
unknown, P. 114460 - 114460
Published: April 1, 2025
Language: Английский