International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 6573 - 6590
Published: May 1, 2025
Language: Английский
Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 599 - 626
Published: Jan. 1, 2025
Silk protein, as a natural polymer material with unique structures and properties, exhibits tremendous potential in the biomedical field. Given limited production restricted properties of silk proteins, molecular biotechnology has been extensively applied protein genetic engineering to produce novel proteins specific properties. This review outlines roles major model organisms, such silkworms spiders, production, provides detailed introduction applications gene editing technologies (eg, CRISPR-Cas9), transgenic expression technologies, synthetic biology techniques engineering. By analyzing factors influencing expression, this further elaborates on innovative drug delivery systems, tissue regenerative medicine skin, bone, cartilage, vascular repair), well antibacterial immune strategies. Notably, modified expressed by demonstrate significant advantages enhancing bioavailability promoting cell proliferation differentiation. In conclusion, engineering, through continuous innovations biotechnology, provided an effective pathway for high-performance materials. The extensive these field have not only expanded functionality but also offered new approaches address medical challenges. future, development will rely interdisciplinary integration promote in-depth research expansion industrial proteins.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143068 - 143068
Published: April 1, 2025
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 6573 - 6590
Published: May 1, 2025
Language: Английский
Citations
0