Unraveling DINCH – Induced hepatotoxicity mechanisms via network toxicology and molecular docking with experimental validation DOI

Jingxin Xin,

Chengbin Zhou,

Ying Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 299, P. 118305 - 118305

Published: May 19, 2025

Language: Английский

Ferroptosis as a key player in the pathogenesis and intervention therapy in liver injury: focusing on drug-induced hepatotoxicity DOI

Bahaa Ibrahim Saeed,

Subasini Uthirapathy,

Aziz Kubaev

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
NAT2 Acetylation Status Predicts Hepatotoxicity During Antituberculosis Therapy: Cumulative Risk Analysis of a Multiethnic Cohort DOI Open Access
Marco Schiuma,

Sofia Dinegro,

Vera Battini

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3881 - 3881

Published: April 19, 2025

Antituberculosis drug-induced hepatotoxicity (ATDH) is a common adverse drug reaction often requiring treatment interruption, complicating tuberculosis management. The slow acetylator phenotype, characterized by reduced N-acetyltransferase 2 (NAT2) enzyme activity, associated with increased risk, while rapid acetylators are higher risk of therapeutic failure. This study investigates the association between NAT2 acetylation phenotype and ATDH occurrence, an emphasis on its predictive value in regard to multiethnic population impact timing onset. A retrospective observational was conducted patients treated at Luigi Sacco Hospital, Milan, Italy (July 2020-September 2023). genotyping identified rapid/intermediate acetylators. Cumulative incidence analysis Fine-Gray competing risks regression models were used assess onset timing. Among 102 patients, 21.6% developed ATDH, including 16.7% 4.9% significantly earlier (median 0.5 vs. months, interquartile range-IQR: 0.5-3 1.7-5.5). Slow developing (Sub-distribution hazard ratio, SHR = 3.05; 95% confidence interval-CI: 1.17-7.95; p 0.02), even after adjusting for confounders. strongly influences Early status identification may enable dose adjustments, enhancing safety. These findings highlight role pharmacogenetics optimizing antituberculosis therapy improving efficacy minimizing toxicity.

Language: Английский

Citations

0
TJ0113-induced mitophagy in acute liver failure detected by Raman microspectroscopy DOI Creative Commons
Chunlian Huang,

Jiaqi Liao,

Xufeng Cen

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: 83, P. 103654 - 103654

Published: April 30, 2025

Language: Английский

Citations

0
A new incompatible combination: Reynoutria multiflora combined with Cullen corylifolium enhances idiosyncratic hepatotoxicity under immunological stress DOI
Li Lin,

Longxin Guo,

Mary V. Long

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119986 - 119986

Published: May 1, 2025

Language: Английский

Citations

0
Unraveling DINCH – Induced hepatotoxicity mechanisms via network toxicology and molecular docking with experimental validation DOI

Jingxin Xin,

Chengbin Zhou,

Ying Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 299, P. 118305 - 118305

Published: May 19, 2025

Language: Английский

Citations

0