Uncovering layer by layer the risk of nanoplastics to the environment and human health DOI
Joana Antunes, Paula Sobral, Vasco Branco

et al.

Journal of Toxicology and Environmental Health Part B, Journal Year: 2024, Volume and Issue: 28(2), P. 63 - 121

Published: Dec. 13, 2024

Nanoplastics (NPs), defined as plastic particles with dimensions less than 100 nm, have emerged a persistent environmental contaminant potential risk to both environment and human health. might translocate across biological barriers accumulate in vital organs, leading inflammatory responses, oxidative stress, genotoxicity, already reported several organisms. Disruptions cellular functions, hormonal balance, immune responses were also linked NPs exposure vitro assays. Further, been found adsorb other pollutants, such organic pollutants (POPs), leach additives potentially amplifying their advere impacts, increasing the threat organisms greater alone. However, toxic effects remain largely unexplored, requiring further research elucidate risks health, especially accumulation, degradation, migration, interactions systems long-term consequences of chronic these compounds. This review provides an overview current state-of-art regarding mechanisms toxicity within cells.

Language: Английский

Ecotoxicological bioassays with terrestrial plants: a holistic view of standards, guidelines, and protocols DOI
Leonardo Mendes da Silva, Larissa Fonseca Andrade‐Vieira

Journal of Toxicology and Environmental Health Part B, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 39

Published: Jan. 5, 2025

Terrestrial and aquatic ecosystems face various chemicals that might induce acute and/or long-term harm. To assess these impacts, ecotoxicological bioassays are essential. However, using animals, particularly mammals, costly, time-consuming, raise ethical concerns. In this context, terrestrial plants emerge as a viable alternative to conventional assays. Thus, the aim of review was address history evolution plant bioassays, highlighting main regulations, guidelines, protocols governing use in tests. Initially, were employed cytogenotoxic effects chemicals, gaining prominence with GENE-TOX program 80s. Subsequently, used allelopathy studies aimed examine ecotoxicity pesticides soil. Currently, regulated by specific standards, such ASTM E1963–22, EPA 600/3–88/029, EPS 1/RM/45, ISO 11269-1, 11269-2, 17126, 18763, 29200, 22030, OECD-208, OECD-227, OCSPP 850.4100, 850.4230, 850.4800 OPPTS 850.4200. The existing standardize greenhouse lab environments, duration tests varies from hours months. parameters be analyzed after exposure include germination percentage, survival rate, root length, aerial part fresh mass exposed plants, phytotoxicity symptoms. addition, absorption rate substances genotoxic mutagenic also assessed. Therefore, data demonstrate represent an important tool analysis environmental risks associated serve crucial allies modern ecotoxicology.

Language: Английский

Citations

5
Tracing the Footprint of Microplastics: Transport Mechanism, Degradation, and Remediation in Marine Environment DOI
Arkadeep Mukherjee,

Shivani Kumar S,

Randeep Singh

et al.

Water Air & Soil Pollution, Journal Year: 2025, Volume and Issue: 236(2)

Published: Jan. 24, 2025

Language: Английский

Citations

2
The biological and sociological implications of diversity, equity, and inclusion (DEI): life within microbiomes and on earth DOI
David A. Lawrence,

Brandon O’Sullivan,

Joerg Graf

et al.

Journal of Toxicology and Environmental Health Part B, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: April 29, 2025

From a biological point of view, Diversity, Equity, and Inclusion (DEI) are important at multiple levels, which include our genetics, microbiomes, diets, all organ system interactions. Considering only DEI's sociological aspects is equivalent to the error "throwing out baby with bath water." Variances in microbial diversity within microbiomes might affect health through systemic interactions affecting metabolites, maintaining immune homeostasis, wound healing cellular damage from an infection, physical stress, or psychological trauma. An imbalance cell subsets, both innate adaptive, microbes any lead more excessive inflammation oxidative stress less regulation. The dysregulation may occur due loss endometrial barriers enabling spread microbes, environmental pollutants, allergens. Heat waves, sleep deprivation, increased prevalence pollutants such as polychlorinated biphenyls, weaken endothelial barriers, be responsible for enhanced stresses. Leakage useful gut microbiota into periphery initiate inflammatory responses, altered microbiome gut-brain axis that influences mental health.

Language: Английский

Citations

0
Microplastic Pollution and Its Physiological Effects on the Top Fish Predator Dentex dentex from the Western Mediterranean DOI Creative Commons
Amanda Cohen-Sánchez,

Antònia Solomando,

Montserrat Compa

et al.

Microplastics, Journal Year: 2025, Volume and Issue: 4(2), P. 28 - 28

Published: May 22, 2025

Microplastic (MP) pollution is a growing environmental concern, particularly in marine ecosystems. This study investigated the presence and effects of MPs common dentex (Dentex dentex), commercially ecologically important species Mediterranean Sea. Fish (n = 22) were collected from Ibiza’s coastal waters (western Mediterranean, Spain), their gastrointestinal tracts analysed to determine MP ingestion rates potential physiological impacts. detected 90.9% specimens, with an average 6.6 ± 1.2 per individual. Fibres accounted for 78.9% fragments 21.1%. Stress detoxification biomarkers assessed by categorizing fish into two groups based on load: low (<6 MPs) high (≥6 MPs). higher loads showed significantly increased antioxidant enzyme activities digestive tract, while malondialdehyde levels remained similar between groups. No significant differences observed liver biomarkers. These findings indicate that triggers responses D. dentex, activating defences tract. However, lack response suggests load not sufficient induce systemic changes. Further research needed assess long-term consequences health ecosystem sustainability.

Language: Английский

Citations

0
Uncovering layer by layer the risk of nanoplastics to the environment and human health DOI
Joana Antunes, Paula Sobral, Vasco Branco

et al.

Journal of Toxicology and Environmental Health Part B, Journal Year: 2024, Volume and Issue: 28(2), P. 63 - 121

Published: Dec. 13, 2024

Nanoplastics (NPs), defined as plastic particles with dimensions less than 100 nm, have emerged a persistent environmental contaminant potential risk to both environment and human health. might translocate across biological barriers accumulate in vital organs, leading inflammatory responses, oxidative stress, genotoxicity, already reported several organisms. Disruptions cellular functions, hormonal balance, immune responses were also linked NPs exposure vitro assays. Further, been found adsorb other pollutants, such organic pollutants (POPs), leach additives potentially amplifying their advere impacts, increasing the threat organisms greater alone. However, toxic effects remain largely unexplored, requiring further research elucidate risks health, especially accumulation, degradation, migration, interactions systems long-term consequences of chronic these compounds. This review provides an overview current state-of-art regarding mechanisms toxicity within cells.

Language: Английский

Citations

1