Lion’s Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential—A Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1307 - 1307

Published: April 9, 2025

Hericium erinaceus, commonly known as lion’s mane mushroom, has gained increasing scientific interest due to its rich composition of bioactive compounds and diverse health-promoting properties. This narrative review provides a comprehensive overview the nutritional therapeutic potential H. with particular focus on anti-inflammatory, antioxidant, antimicrobial activities. A structured literature search was performed using databases such PubMed, Scopus, Science Direct, Web Science, Google Scholar. Studies published in last two decades focusing erinaceus’ were included. The chemical erinaceus includes polysaccharides, terpenoids (hericenones erinacines), phenolic compounds, which exhibit potent antioxidant effects by scavenging reactive oxygen species (ROS) inducing endogenous enzymes. Additionally, shows promising activity against bacterial fungal pathogens, applications combating antibiotic-resistant infections. mushroom’s capacity stimulate nerve growth factor (NGF) synthesis highlighted preventing managing neurodegenerative diseases, Alzheimer’s Parkinson’s. Advances biotechnological methods, including optimized cultivation techniques novel extraction may further enhance bioavailability pharmacological erinaceus. Despite findings, clinical validation remains limited. Future research should prioritize large-scale trials, standardization elucidation pharmacokinetics facilitate integration into evidence-based medicine. functional food, nutraceutical, adjunct agent highlights need for interdisciplinary collaboration between researchers, clinicians, regulatory bodies.

Language: Английский

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Antimicrobial Potential of Secalonic Acids from Arctic-Derived Penicillium chrysogenum INA 01369

Antibiotics, Journal Year: 2025, Volume and Issue: 14(1), P. 88 - 88

Published: Jan. 14, 2025

In this study, two compounds have been isolated from the Arctic-derived fungus Penicillium chrysogenum INA 13460. Structural elucidation, performed using 2D NMR and HR-ESIMS data, has identified as stereoisomers of secalonic acids, dimeric tetrahydroxanthones. The absolute configurations these determined through conformational analysis circular dichroism spectroscopy. antimicrobial activity acids D F evaluated against a diverse range microorganisms, including Gram-positive multidrug-resistant Staphylococcus aureus, Gram-negative Escherichia coli ATCC 25922, Pseudomonas aeruginosa 27853, phytopathogen Pectobacterium carotovorum VKM-B1247, fungi Fusarium oxysporum VKPM 890, Aspergillus fumigatus VKM F-37, A. niger 16404. Genomic chemical analyses further support P. 13460 promising natural source for drug discovery biological control applications.

Language: Английский

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Harnessing the CRISPR/Cas9 in filamentous fungi for the production of secondary metabolites

Systems Microbiology and Biomanufacturing, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

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Bioprospecting of Fungi for Anticancer Compounds

Published: Jan. 1, 2025

Language: Английский

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Multidimensional insights into squalene epoxidase drug development: in vitro mechanisms, in silico modeling, and in vivo implications

Expert Opinion on Therapeutic Targets, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Squalene epoxidase (SQLE) is a pivotal enzyme in sterol biosynthesis, catalyzing the conversion of squalene to 2,3-oxidosqualene. Beyond its core role cholesterol homeostasis, SQLE implicated cancer, hypercholesterolemia, and fungal infections, positioning it as valuable therapeutic target. We conducted comprehensive literature search across primary databases gather vitro, silico, vivo evidence on SQLE. This review explores enzyme's structural functional features, including substrate specificity catalytic mechanisms, examines inhibitor interactions. Computational methods predict - dynamics, guiding drug design, while investigations clarify SQLE's metabolic disorders tumorigenesis. Challenges include resistance study discrepancies, but emerging technologies, such cryo-electron microscopy CRISPR editing, offer new avenues for deeper exploration. an underexplored yet promising target, with particular relevance oxidative stress, ferroptosis, gut microbiota research. Overcoming current barriers through advanced technologies multidisciplinary strategies could propel SQLE-targeted treatments into clinical practice, supporting precision medicine broader translational applications.

Language: Английский

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Advances in CRISPR/Cas9-Based Gene Editing in Filamentous Fungi

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(5), P. 350 - 350

Published: May 1, 2025

As an important class of microorganisms, filamentous fungi have crucial roles in protein secretion, secondary metabolite production and environmental pollution control. However, characteristics such as apical growth, heterokaryon, low homologous recombination (HR) efficiency the scarcity genetic markers mean that application traditional gene editing technology faces great challenges. The introduction RNA-mediated CRISPR/Cas (clustered regularly interspaced short palindromic repeat/CRlSPR-associated protein) system recent years has revolutionized fungi. In addition, continuously expressed CRISPR significantly improved efficiency, while optimized sgRNA design reduced cas9 concentration effectively off-target effect, further enhancing safety reliability technology. this review, we systematically analyze molecular mechanism regulatory factors CRISPR/Cas9, focus on optimization its expression improvement transformation fungi, reveal core HR non-homologous end-joining (NHEJ) pathways editing. Based analysis various applications, review reveals outstanding advantages CRISPR/Cas9 enhancement addresses reconstruction metabolic pollutant degradation past decade, provides a theoretical basis practical guidance for engineering applications.

Language: Английский

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Insights into carbon dots synthesized from fungal sources

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: June 4, 2025

Language: Английский

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