Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: 498, P. 117301 - 117301
Published: March 13, 2025
Language: Английский
Anti-Cancer Drugs, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
The uncertain ferroptosis-related role of berberine in prostate cancer was explored using network pharmacology methodology. Integration ferroptosis targets from the Genecard database and Traditional Chinese Medicine Systems Pharmacology SwissTargetPrediction databases revealed 17 common targets. Among these, 10 hub genes, including CCNB1 , CDK1 AURKA AR CDC42 ICAM1 TYMS NTRK1 PTGS 2, SCD were identified. Enrichment analyses yielded 799 Gene Ontology terms 23 Kyoto Encyclopedia Genes Genomes pathways associated with berberine-related Molecular docking simulations indicated berberine’s binding capacity to all genes. In-vitro studies on LNCaP PC3 cells demonstrated inhibition cell proliferation significant downregulation both lines. Berberine exhibited line-specific effects by reducing expression suppressing cells. Overall, shows promise inhibiting progression through modulation .
Language: Английский
Citations
0
Integrative Cancer Therapies, Journal Year: 2025, Volume and Issue: 24
Published: Jan. 1, 2025
Screening for pulmonary nodules (PN) using low-dose CT has proven effective in reducing lung cancer (LC) mortality. However, current treatments relying on follow-up and surgical excision fail to fully address clinical needs. Pathological angiogenesis plays a pivotal role supplying oxygen necessary the progression of PN LC. The interplay between hypoxia establishes vicious cycle, rendering anti-angiogenesis therapy alone insufficient prevent LC transformation. In traditional Chinese medicine (TCM), is referred as "Feiji," which mainly attributed Qi blood deficiency, correspondingly, most commonly prescribed medicines are Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao (huang qi) (AR) Angelica sinensis (Oliv.) Diels (dang gui) (ARS). Modern pharmacological studies have demonstrated that AR ARS possess immune-enhancing, anti-tumor, anti-inflammatory, anti-angiogenic properties. precise mechanisms through exert effects delay remain inadequately understood. This review explores critical roles transition from It emphasizes that, compared therapies targeting angiogenic growth factors alone, AR, ARS, their compound-based prescriptions offer additional benefits. These include ameliorating by restoring composition, enhancing vascular structure, accelerating circulation, promoting normalization, blocking or inhibiting various pro-angiogenic expressions receptor interactions. Collectively, these actions inhibit PN-to-LC Finally, this summarizes recent advancements related research, identifies existing limitations gaps knowledge, proposes potential strategies recommendations challenges.
Language: Английский
Citations
0
Redox Biology, Journal Year: 2025, Volume and Issue: 82, P. 103579 - 103579
Published: March 9, 2025
Bronchopulmonary dysplasia (BPD) is a prevalent chronic respiratory condition in preterm infants with an increasing incidence, severely affecting their survival rate and quality of life. Exploring the underlying mechanisms BPD helps to develop novel effective therapeutic strategies. In this study, integrated metabolomic analyses tracheal aspirates (TAs) from non-BPD infants, along lung tissues hyperoxia-induced experimental neonatal rats control rats, demonstrated that was associated significant reduction 3-hydroxyanthranilic acid (3-HAA), which confirmed be partly caused by tryptophan-metabolizing enzyme disorders. vivo vitro models were subsequently established assess efficacy 3-HAA relation BPD. Compared group, nebulization improved development suppressed inflammation rats. Limited proteolysis-small molecule mapping (LiP-SMap) proteomic analysis revealed involvement ferroptosis pathway mechanism alleviated injury. Ferroptosis identified detecting Fe2+ levels, malondialdehyde (MDA), 4-HNE, total aldehydes, mitochondrial morphology, ferroptosis-associated protein mRNA expression, dysregulation indeed ameliorated vivo. Furthermore, combination LiP-SMap, molecular docking, SPR Co-IP can bind directly FTH1 disrupt nuclear receptor coactivator 4 (NCOA4)-FTH1 interaction. conclusion, our study first reveal linked 3-HAA, could inhibit targeting FTH1, thereby alleviating injury alveolar type II epithelial cells, highlighting potential for clinical applications
Language: Английский
Citations
0
Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: 498, P. 117301 - 117301
Published: March 13, 2025
Language: Английский
Citations
0