Endotyping Insulin–Glucose Homeostasis in Hidradenitis Suppurativa: The Impact of Diabetes Mellitus and Inflammation DOI Open Access
Nessr Abu Rached, Johannes W. Dietrich, Lennart Ocker

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2145 - 2145

Published: March 21, 2025

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease often associated with metabolic disorders such as diabetes mellitus. Recent research suggests link between systemic inflammation and insulin-glucose dysregulation in HS. This study investigates the relationship homeostasis, mellitus haptoglobin concentration HS patients. Methods: We assessed 95 patients 49 controls using validated fasting-based function tests, including Structural Parameter Inference Approach (SPINA), Homeostasis Model Assessment (HOMA) Quantitative Insulin Sensitivity Check Index (QUICKI). Results: The had significantly higher fasting insulin (97.2 vs. 69.0 pmol/L, p = 0.035), increased resistance (HOMA-IR: 3.47 2.57, 0.016) impaired sensitivity (SPINA-GR: 1.34 1.76 mol/s, 0.017). In diabetes, was more strongly reduced 0.61 1.41 0.0057) 7.3 3.2, Higher concentrations were accompanied by worse glycaemic control, demonstrating elevated glucose (5.77 5.11 mmol/L, 0.043) HbA1c (5.7% 5.4%, 0.0081) fraction. Conclusions: Our findings suggest that contributes to dysregulation, worsening particularly those or diabetes.

Language: Английский

Endotyping Insulin–Glucose Homeostasis in Hidradenitis Suppurativa: The Impact of Diabetes Mellitus and Inflammation DOI Open Access
Nessr Abu Rached, Johannes W. Dietrich, Lennart Ocker

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2145 - 2145

Published: March 21, 2025

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease often associated with metabolic disorders such as diabetes mellitus. Recent research suggests link between systemic inflammation and insulin-glucose dysregulation in HS. This study investigates the relationship homeostasis, mellitus haptoglobin concentration HS patients. Methods: We assessed 95 patients 49 controls using validated fasting-based function tests, including Structural Parameter Inference Approach (SPINA), Homeostasis Model Assessment (HOMA) Quantitative Insulin Sensitivity Check Index (QUICKI). Results: The had significantly higher fasting insulin (97.2 vs. 69.0 pmol/L, p = 0.035), increased resistance (HOMA-IR: 3.47 2.57, 0.016) impaired sensitivity (SPINA-GR: 1.34 1.76 mol/s, 0.017). In diabetes, was more strongly reduced 0.61 1.41 0.0057) 7.3 3.2, Higher concentrations were accompanied by worse glycaemic control, demonstrating elevated glucose (5.77 5.11 mmol/L, 0.043) HbA1c (5.7% 5.4%, 0.0081) fraction. Conclusions: Our findings suggest that contributes to dysregulation, worsening particularly those or diabetes.

Language: Английский

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