METTL3-mediated m6A modification in sepsis: current evidence and future perspectives DOI
Zijun Wu, Changhong Miao, Hao Zhang

et al.

Epigenomics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: April 19, 2025

Sepsis, a severe systemic inflammatory condition triggered by infection, is associated with high morbidity and mortality worldwide. While medical diagnosis treatment have advanced in recent years, specific therapy remains unavailable. Recently, significant progress has been made studying the epigenetic RNA modification N6-methyladenosine (m6A) its core methyltransferase METTL3. The role of m6A sepsis also increasingly elucidated. This review aims to explore pathological mechanisms relationship m6A, focusing on key writer, METTL3, sepsis.

Language: Английский

METTL3-mediated m6A modification in sepsis: current evidence and future perspectives DOI
Zijun Wu, Changhong Miao, Hao Zhang

et al.

Epigenomics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: April 19, 2025

Sepsis, a severe systemic inflammatory condition triggered by infection, is associated with high morbidity and mortality worldwide. While medical diagnosis treatment have advanced in recent years, specific therapy remains unavailable. Recently, significant progress has been made studying the epigenetic RNA modification N6-methyladenosine (m6A) its core methyltransferase METTL3. The role of m6A sepsis also increasingly elucidated. This review aims to explore pathological mechanisms relationship m6A, focusing on key writer, METTL3, sepsis.

Language: Английский

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