Linking Striatal Dopaminergic Asymmetry with Personality Traits: Insights from Gambling Disorder DOI Creative Commons
Francesco Di Carlo, Mauro Pettorruso, Mario Santorelli

et al.

Journal of Gambling Studies, Journal Year: 2024, Volume and Issue: 40(4), P. 2189 - 2200

Published: May 16, 2024

Abstract The role of dopamine in the pathophysiology gambling disorder (GD) remains incompletely understood, with disparate research findings concerning presynaptic and postsynaptic structures dopaminergic synthesis. aim this study was to investigate potential correlations between striatal transporter (DAT) lateralization asymmetry index, as assessed by 123 I-FP-CIT SPECT, temperamental traits, measured Cloninger’s Temperament Character Inventory (TCI), GD subjects. Significant associations were found DAT binding asymmetries caudate putamen dimensions harm avoidance novelty seeking. Specifically, high seeking scores correlated increased left relative right, whereas higher corresponded right left. These observations potentially imply that expression basal ganglia could be an outcome hemispheric emotional processing behavioural guidance. In summary, our provides evidence supporting relationship asymmetries, GD. Future investigations directed towards examining receptors gain a more comprehensive understanding dopamine's influence within circuit disordered gambling. If confirmed larger cohorts, these have substantial implications for tailoring individualized neuromodulation therapies treatment addictions.

Language: Английский

Pharmacological management of gambling disorder: an update of the literature DOI
Gemma Mestre‐Bach, Marc N. Potenza

Expert Review of Neurotherapeutics, Journal Year: 2024, Volume and Issue: 24(4), P. 391 - 407

Published: Feb. 15, 2024

Introduction Gambling disorder (GD) is a mental health condition characterized by persistent and problematic betting behavior. GD generates distress impairment, treatment options include psychological pharmacological interventions.

Language: Английский

Citations

5
Comparing Efficacy of Serotonergic, Opioidergic, and Glutamatergic Drugs in Gambling Disorder: A Pooled Analysis of Response Trajectories versus Placebo DOI
Mauro Pettorruso, Francesco Di Carlo, Giorgio Di Lorenzo

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Linking Striatal Dopaminergic Asymmetry with Personality Traits: Insights from Gambling Disorder DOI Creative Commons
Francesco Di Carlo, Mauro Pettorruso, Mario Santorelli

et al.

Journal of Gambling Studies, Journal Year: 2024, Volume and Issue: 40(4), P. 2189 - 2200

Published: May 16, 2024

Abstract The role of dopamine in the pathophysiology gambling disorder (GD) remains incompletely understood, with disparate research findings concerning presynaptic and postsynaptic structures dopaminergic synthesis. aim this study was to investigate potential correlations between striatal transporter (DAT) lateralization asymmetry index, as assessed by 123 I-FP-CIT SPECT, temperamental traits, measured Cloninger’s Temperament Character Inventory (TCI), GD subjects. Significant associations were found DAT binding asymmetries caudate putamen dimensions harm avoidance novelty seeking. Specifically, high seeking scores correlated increased left relative right, whereas higher corresponded right left. These observations potentially imply that expression basal ganglia could be an outcome hemispheric emotional processing behavioural guidance. In summary, our provides evidence supporting relationship asymmetries, GD. Future investigations directed towards examining receptors gain a more comprehensive understanding dopamine's influence within circuit disordered gambling. If confirmed larger cohorts, these have substantial implications for tailoring individualized neuromodulation therapies treatment addictions.

Language: Английский

Citations

2