Design, synthesis, and biological evaluation of novel 3-naphthylthiophene derivatives as potent SIRT2 inhibitors for the treatment of myocardial fibrosis DOI
Zhuo Zhang, Chao Ma, Xiong Gao

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108033 - 108033

Published: Dec. 6, 2024

Language: Английский

Integrative transcriptomics and proteomics analysis reveal the protection of Astragaloside IV against myocardial fibrosis by regulating senescence DOI Creative Commons
Lipeng Shi, Jingwei Deng, Jun He

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 975, P. 176632 - 176632

Published: May 6, 2024

Myocardial fibrosis (MF) is a pivotal pathological process implicated in various cardiovascular diseases, particularly heart failure. Astragaloside IV (AS-IV), natural compound derived from Astragalus membranaceus, possesses potent cardioprotective properties. However, the precise molecular mechanisms underlying its anti-MF effects, relation to senescence, remain elusive. Thus, this study aimed investigate therapeutic potential and of AS-IV treating ISO-induced MF mice, employing transcriptomics, proteomics, vitro, vivo experiments. We assessed positive effects on using HE staining, Masson ELISA, immunohistochemical transthoracic echocardiography, transmission electron microscopy, DHE fluorescence staining. Additionally, we elucidated regulatory role through comprehensive transcriptomics proteomics analyses, complemented by Western blotting RT-qPCR validation pertinent pathways. Our findings demonstrated that treatment markedly attenuated myocardial injury oxidative stress, concomitantly inhibiting release SASPs. Furthermore, integrated analyses revealed mechanism was associated with regulating cellular senescence p53 signaling pathway. These results highlight exerts not only stress but also modulating

Language: Английский

Citations

9
Role of macrophage polarization in heart failure and traditional Chinese medicine treatment DOI Creative Commons

Zheqin Zhu,

Min Wang, Shenghua Lu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 18, 2024

Heart failure (HF) has a severe impact on public health development due to high morbidity and mortality is associated with imbalances in cardiac immunoregulation. Macrophages, major cell population involved immune response inflammation, are highly heterogeneous polarized into M1 M2 types depending the microenvironment. macrophage releases inflammatory factors chemokines activate remove harmful substances, while anti-inflammatory inhibit overactive promote tissue repair. restrict each other maintain homeostasis. The dynamic balance of closely related Traditional Chinese Medicine (TCM) yin-yang theory, imbalance yin yang will result pathological state organism. Studies have confirmed that TCM produces positive effects HF by regulating polarization. This review describes critical role polarization fibrosis, angiogenesis electrophysiology course HF, as well potential mechanism regulation preventing treating thereby providing new ideas for clinical treatment scientific research design HF.

Language: Английский

Citations

4
Baricitinib represses the myocardial fibrosis via blocking JAK/STAT and TGF-β1 pathways in vivo and in vitro DOI Creative Commons
R Feng, Hongli Liu, Yunqing Chen

et al.

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 31, 2025

JAK/STAT pathway is closely involved in the organ fibrotic process. The current study aimed to investigate impact of baricitinib, an oral selective JAK1/JAK2 inhibitor, on myocardial fibrosis vivo and activation cardiac fibroblasts vitro. mouse model was established by isoproterenol (ISO) treatment, then treated baricitinib. TGF-β1 stimulation, baricitinib with several concentrations. Besides, JAK2 knocked down small interfering RNA (siRNA) TGF-β1-stimulated fibroblasts. Baricitinib not only attenuated cell widening, inflammatory infiltration, fibrous tissue, heart index, but also reduced collagen volume fraction, expressions Col1, Col3, α-SMA, Fn, MMP9, TIMP1 ISO-induced mice. Meanwhile, decreased p-STAT3 TGF-βRII these Interestingly, fibroblasts, a dose-dependent manner (From 10 2000 nM), exhibited TGF-βRII. Finally, knockdown siRNA downregulated Fn Inhibition represses vitro, indicating may be treatment option for fibrosis, while further validation needed.

Language: Английский

Citations

0
Qing-Xin-Jie-Yu Granule attenuates myocardial infarction-induced inflammatory response by regulating the MK2/TTP pathway DOI Creative Commons

Jianghan Qi,

Xiaoyao Gao,

Ying Han

et al.

Pharmaceutical Biology, Journal Year: 2025, Volume and Issue: 63(1), P. 128 - 140

Published: Feb. 21, 2025

Context Qing-Xin-Jie-Yu Granule (QXJYG) has shown promise in the treatment of myocardial infarction. However, mechanism action QXJYG underlying its anti-inflammation remain unknown.

Language: Английский

Citations

0
Emerging role of mesenchymal cells in cardiac and cerebrovascular diseases: Physiology, pathology, and therapeutic implications DOI

Kajal Kumari,

Kanika Verma, Mukesh Sahu

et al.

Vascular Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 107473 - 107473

Published: Feb. 1, 2025

Language: Английский

Citations

0
Macrophages of the Heart: Homeostasis and Disease DOI Creative Commons

Koketso C Mabatha,

Pheletso Letuka,

Olukayode O. Aremu

et al.

Biomedical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 100867 - 100867

Published: April 1, 2025

Cardiac macrophages (CMs) are the most abundant immune cell type in heart. They critical for maintaining cardiac homeostasis and orchestration of responses to ischemic non-ischemic cardiomyopathies. Their functions highly heterogeneous regulated by their tissue microenvironment. CMs have high plasticity, which allows them perform various myocardium bring about within cardiovascular system (CVS). also play roles coronary development angiogenesis, repair remodeling, conduction clearance necrotic apoptotic cells. However, there is a paucity studies on biology both steady state disease, especially, humans. In this review, we discuss multifaceted heart, focusing ontogeny, homeostatic immunological during inflammation reparative processes post-injury. We highlight heterogeneity phenotypes as well pathogenesis pathological conditions such myocarditis, myocardial fibrosis heart failure. Understanding unique characteristics milieu macrophage-specific therapeutic interventions alleviate global burden disease (CVD). Therefore, future should focus further improving understanding harness potential targets disorders.

Language: Английский

Citations

0
Current state of heart failure treatment: are mesenchymal stem cells and their exosomes a future therapy? DOI Creative Commons
Chengqian Chen, Wentao Zhong,

Hao Zheng

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 28, 2025

Heart failure (HF) represents the terminal stage of cardiovascular disease and remains a leading cause mortality. Epidemiological studies indicate high prevalence mortality rate HF globally. Current treatment options primarily include pharmacological non-pharmacological approaches. With development mesenchymal stem cell (MSC) transplantation technology, increasing research has shown that therapy exosomes derived from these cells hold promise for repairing damaged myocardium improving cardiac function, becoming hot topic in clinical HF. However, this approach also presents certain limitations. This review summarizes mechanisms HF, current strategies, latest progress application MSCs their therapy.

Language: Английский

Citations

0
A secretome atlas of cardiac fibroblasts from healthy and infarcted mouse hearts DOI Creative Commons
Jasmin Bahr, Gereon Poschmann,

Andreas Jungmann

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: April 29, 2025

Language: Английский

Citations

0
Knockdown of ANO1 decreases TGF-β- and IL-6-induced adhesion and migration of cardiac fibroblasts by inhibiting the expression of integrin and focal adhesion kinase DOI
Xiangqin Tian, Yajing Zhang,

Hanyang Gong

et al.

Experimental Cell Research, Journal Year: 2024, Volume and Issue: 443(1), P. 114321 - 114321

Published: Nov. 1, 2024

Language: Английский

Citations

1
Design, synthesis, and biological evaluation of novel 3-naphthylthiophene derivatives as potent SIRT2 inhibitors for the treatment of myocardial fibrosis DOI
Zhuo Zhang, Chao Ma, Xiong Gao

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108033 - 108033

Published: Dec. 6, 2024

Language: Английский

Citations

0