Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 22, 2025
Metabolic
regulation
of
cell
death
has
become
a
potential
therapeutic
target
for
kidney
renal
clear
carcinoma
(KIRC),
which
is
distinguished
by
notable
heterogeneity
and
significant
immune
infiltration.
Disulfidptosis,
recently
identified
form
death,
gained
prominence
in
antitumor
immunity.
This
research
aims
to
investigate
the
correlation
between
disulfidptosis
prognosis
KIRC,
while
also
exploring
possibility
predicting
response
disulfidptosis-associated
genes
(DAGs).
We
sourced
clinical
data
RNA
sequence
KIRC
from
Cancer
Genome
Atlas
Database.
Employing
unsupervised
clustering
based
on
23
DAGs,
we
further
key
differentially
expressed
(DEGs)
clusters
construct
DAG
prognostic
signature.
A
nomogram
was
developed
validated
predict
outcome
KIRC.
Finally,
examined
infiltration,
tumor
mutational
burden,
immunotherapy
response,
sensitivity
drugs
high
low-risk
groups.
Two
distinct
patient
were
successfully
stratified
using
23-DAG-related
signature,
comprising
11
genes.
resulted
robust
risk
model
with
strong
predictive
accuracy
overall
survival.
The
nomogram,
incorporating
DAG-based
scores,
age,
pM
stage,
exhibited
excellent
performance.
high-risk
group
displayed
increased
infiltration
showed
heightened
immunotherapies
targeted
treatments.
study
established
highlighting
its
landscape
responses.
Novel
disulfidptosis-related
biomarkers
revealed
profiles,
drug
sensitivities,
potentials
among
patients.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(4), P. 1071 - 1071
Published: April 2, 2023
Renal
cell
carcinoma
(RCC)
is
the
seventh
most
common
cancer
in
men
and
ninth
women
worldwide.
There
plenty
of
evidence
about
role
immune
system
surveillance
against
tumors.
Thanks
to
a
better
understanding
immunosurveillance
mechanisms,
immunotherapy
has
been
introduced
as
promising
treatment
recent
years.
long
thought
chemoresistant
but
highly
immunogenic.
Considering
that
up
30%
patients
present
metastatic
disease
at
diagnosis,
around
20–30%
undergoing
surgery
will
suffer
recurrence,
we
need
identify
novel
therapeutic
targets.
The
introduction
checkpoint
inhibitors
(ICIs)
clinical
management
RCC
revolutionized
approach
this
tumor.
Several
trials
have
shown
therapy
with
ICIs
combination
or
tyrosine
kinase
inhibitor
very
good
response
rate.
In
review
article
summarize
mechanisms
immunity
modulation
checkpoints
discuss
potential
strategies
renal
treatment.
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(12), P. 3888 - 3888
Published: June 7, 2023
Globally,
clear-cell
renal
cell
carcinoma
(ccRCC)
represents
the
most
prevalent
type
of
kidney
cancer.
Surgery
plays
a
key
role
in
treatment
this
cancer,
although
one
third
patients
are
diagnosed
with
metastatic
ccRCC
and
about
25%
will
develop
recurrence
after
nephrectomy
curative
intent.
Molecular-target-based
agents,
such
as
tyrosine
kinase
inhibitors
(TKIs)
immune
checkpoint
(ICIs),
recommended
for
advanced
cancers.
In
addition
to
cancer
cells,
tumor
microenvironment
(TME)
includes
non-malignant
types
embedded
an
altered
extracellular
matrix
(ECM).
The
evidence
confirms
that
interactions
among
cells
TME
elements
exist
thought
play
crucial
roles
development
making
them
promising
therapeutic
targets.
TME,
unfavorable
pH,
waste
product
accumulation,
competition
nutrients
between
may
be
regarded
further
possible
mechanisms
escape.
To
enhance
immunotherapies
reduce
resistance,
it
is
first
understand
how
work
interact
other
cancer-associated
complex
microenvironment.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(22), P. 16515 - 16515
Published: Nov. 20, 2023
The
crosstalk
among
the
complement
system,
immune
cells,
and
mediators
of
inflammation
provides
an
efficient
mechanism
to
protect
organism
against
infections
support
repair
damaged
tissues.
Alterations
in
this
complex
machinery
play
a
role
pathogenesis
different
diseases.
Core
proteins
C3
C5,
their
activation
fragments,
receptors,
regulators
have
been
shown
be
active
intracellularly
as
complosome.
kidney
is
particularly
vulnerable
complement-induced
damage,
emerging
findings
revealed
system
dysregulation
wide
range
disorders,
including
glomerulopathies
ischemia-reperfusion
injury
during
transplantation.
Different
studies
that
important
component
tumorigenesis
its
elements
proved
present
TME
various
human
malignancies.
renal
cell
carcinoma
(RCC)
has
recently
explored.
Clear
papillary
RCC
upregulate
most
genes
relative
normal
tissue.
aim
narrative
review
provide
novel
insights
into
disorders.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(17), P. 13179 - 13179
Published: Aug. 24, 2023
The
term
"cancer
stem
cell"
(CSC)
refers
to
a
cancer
cell
with
the
following
features:
clonogenic
ability,
expression
of
markers,
differentiation
into
cells
different
lineages,
growth
in
nonadhesive
spheroids,
and
vivo
ability
generate
serially
transplantable
tumors
that
reflect
heterogeneity
primary
cancers
(tumorigenicity).
According
this
model,
CSCs
may
arise
from
normal
cells,
progenitor
and/or
differentiated
because
striking
genetic/epigenetic
mutations
or
fusion
tissue-specific
circulating
bone
marrow
(BMSCs).
use
signaling
pathways
similar
those
controlling
fate
during
early
embryogenesis
(Notch,
Wnt,
Hedgehog,
morphogenetic
proteins
(BMPs),
fibroblast
factors,
leukemia
inhibitory
factor,
transforming
factor-β).
Recent
studies
identified
subpopulation
CD133+/CD24+
ccRCC
specimens
displayed
self-renewal
multipotency.
development
agents
targeting
CSC
signaling-specific
not
only
surface
ultimately
become
utmost
importance
for
patients
RCC.
BMC Cancer,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: April 11, 2024
Abstract
Clear
cell
renal
carcinoma
(ccRCC)
is
the
prevailing
histological
subtype
of
and
has
unique
metabolic
reprogramming
during
its
occurrence
development.
Cell
senescence
one
newly
identified
tumor
characteristics.
However,
there
a
dearth
methodical
all-encompassing
investigations
regarding
correlation
between
broad-ranging
alterations
in
processes
associated
with
aging
ccRCC.
We
utilized
range
analytical
methodologies,
such
as
protein‒protein
interaction
network
analysis
least
absolute
shrinkage
selection
operator
(LASSO)
regression
analysis,
to
form
validate
risk
score
model
known
senescence-metabolism-related
(SeMRM).
Our
study
demonstrated
that
SeMRM
could
more
precisely
predict
OS
ccRCC
patients
than
clinical
prognostic
markers
use.
By
utilizing
two
distinct
datasets
ccRCC,
ICGC-KIRC
(the
International
Cancer
Genome
Consortium)
GSE29609,
well
single-cell
dataset
(GSE156632)
real
patient
information,
further
confirmed
relationship
(SeMRS)
progression.
It
worth
noting
who
were
classified
into
different
subgroups
based
on
SeMRS
exhibited
notable
variations
activity,
immune
microenvironment,
type
transformation,
mutant
landscape,
drug
responsiveness.
also
PTGER4,
key
gene
SeMRM,
regulated
proliferation,
lipid
levels
cycle
vivo
vitro.
Together,
utilization
potential
function
dependable
characteristic
increase
accuracy
assessment
for
diagnosed
thereby
facilitating
suitable
treatment
strategies.
Cancer Reports,
Journal Year:
2024,
Volume and Issue:
7(6)
Published: June 1, 2024
Abstract
Clear
cell
renal
carcinoma
(ccRCC)
is
a
common
and
aggressive
subtype
of
kidney
cancer.
Many
patients
are
diagnosed
at
advanced
stages,
making
early
detection
crucial.
Unfortunately,
there
currently
no
noninvasive
tests
for
ccRCC,
emphasizing
the
need
new
biomarkers.
Additionally,
ccRCC
often
develops
resistance
to
treatments
like
radiotherapy
chemotherapy.
Identifying
biomarkers
that
predict
treatment
outcomes
vital
personalized
care.
The
integration
artificial
intelligence
(AI),
multi‐omics
analysis,
computational
biology
holds
promise
in
bolstering
precision
resilience,
opening
avenues
future
investigations.
amalgamation
radiogenomics
biomaterial‐basedimmunomodulation
signifies
revolutionary
breakthrough
diagnostic
medicine.
This
review
summarizes
existing
literature
highlights
emerging
enhance
diagnostic,
predictive,
prognostic
capabilities
setting
stage
clinical
research.
