How can heatstroke damage the brain? A mini review DOI Creative Commons

Kazuhiro Yoneda,

Sanae Hosomi,

Hiroshi Ito

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 10, 2024

Record-breaking heat waves over the past 20 years have led to a global increase in heat-related deaths, including heatstroke. Heat-related illnesses occur when body cannot adapt elevated temperatures environment, leading various symptoms. In severe situations, such as heatstroke, temperature can rise above 40°C, significant injury systems, with particular susceptibility of central nervous system (CNS). Neuroimaging studies conducted months or after heatstroke revealed cellular damage cerebellum and other brain regions, hippocampus, midbrain, thalamus, potential for long-term neurological complications survivors This mini review aimed describe mechanisms pathways underlying development induced by identify diagnostic imaging tools biomarkers CNS due

Language: Английский

Metabolomics Analysis Reveals Potential Biomarkers for Diffuse Axonal Injury Article Category: Original Work DOI
Wei‐Liang Chen, Shengwen Li, Jiayi Wu

et al.

Neurocritical Care, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Language: Английский

Citations

0
The Current Update of Conventional and Innovative Treatment Strategies for Central Nervous System Injury DOI Creative Commons
Meng-Hsuan Tsai,

Chi-Ying Wu,

Chao‐Hsin Wu

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1894 - 1894

Published: Aug. 19, 2024

This review explores the complex challenges and advancements in treatment of traumatic brain injury (TBI) spinal cord (SCI). Traumatic injuries to central nervous system (CNS) trigger intricate pathophysiological responses, frequently leading profound enduring disabilities. article delves into dual phases injury-primary impacts subsequent secondary biochemical cascades-that worsen initial damage. Conventional treatments have traditionally prioritized immediate stabilization, surgical interventions, supportive medical care manage both primary damage associated with injuries. We explore current management strategies, emphasizing crucial role rehabilitation promising potential stem cell therapies immune modulation. Advances therapy, gene editing, neuroprosthetics are revolutionizing approaches, providing opportunities not just for recovery but also regeneration impaired neural tissues. aims emphasize emerging therapeutic strategies that hold promise enhancing outcomes improving quality life affected individuals worldwide.

Language: Английский

Citations

3
Cerebellar Pathology in Forensic and Clinical Neuroscience DOI
Azhagu Madhavan Sivalingam,

Darshitha D Sureshkumar

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102697 - 102697

Published: Feb. 1, 2025

Language: Английский

Citations

0
Neural Stem Cells Transplanted into Rhesus Monkey Cortical Traumatic Brain Injury Can Survive and Differentiate into Neurons DOI Open Access
Shuyi Liu, Liping Shi,

Tianzhuang Huang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1642 - 1642

Published: Jan. 29, 2024

Cortical traumatic brain injury (TBI) is a major cause of cognitive impairment accompanied by motor and behavioral deficits, there no effective treatment strategy in the clinic. Cell transplantation promising therapeutic strategy, it necessary to verify survival differentiation cells after large animal models like rhesus monkeys. In this study, we transplanted neural stem (NSCs) simultaneously injected basic fibroblast growth factor/epidermal factor (bFGF/EGF) into cortex (visual sensory cortices) monkeys with superficial TBI. The results showed that NSCs did not enter cerebrospinal fluid (CSF) were confined site for at least one year. differentiated mature neurons formed synaptic connections host neurons, but glial scar formation between graft tissue occur. This study first explore repairing effect transplanting cerebral TBI, show ability survive long-term differentiate demonstrating potential NSC cortical

Language: Английский

Citations

1
The serum metabolome of diffuse axonal injury patients is distinctive and predictive DOI Creative Commons
Wei-Liang Chen,

Chunyu Yao,

Shengwen Calvin Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 28, 2024

Abstract Background Metabolism is essential for life maintenance, neurological function and injury repair, yet its role in diffuse axonal (DAI) not fully understood. Methods 30 DAI patients 34 non-DAI were recruited based on the classification criteria using Magnetic Resonance Imaging (MRI) within days of admission this exploratory research. Serum samples clinical parameters collected upon admission, with Glasgow Outcome Scale Extended (GOSE) at 6 months post-injury used as functional outcome. The metabolome was assayed liquid chromatography-mass spectrometry. Results group showed significant differences pupillary light reflex, Coma (GCS) score, Marshall computed tomography (CT) well expression levels 27 metabolites serum. Random forest analysis indicated that Lysophosphatidylcholine (LPC) 22:3 sn-2 carnitine C8:1 greatly contributed to distinguishing from (MeanDecreaseGini: 3.81, 5.16). combined prediction these two yielded an area under curve (AUC) 0.944, which higher than combination parameters. Conclusions serum distinctive has value exploring pathogenesis, determining early diagnosis, improving long-term function.

Language: Английский

Citations

0
Metabolomics Analysis Reveals Potential Biomarkers for Diffuse Axonal Injury DOI
Wei-Liang Chen, Guanjun Wang, Jiayi Wu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Abstract Background Metabolism is essential for life maintenance, neurological function and injury repair, yet its role in diffuse axonal (DAI) not fully understood. Methods 30 DAI patients 34 non-DAI were recruited based on the classification criteria using Magnetic Resonance Imaging (MRI) within days of admission this exploratory research. Serum samples clinical parameters collected upon admission, with Glasgow Outcome Scale Extended (GOSE) at 6 months post-injury used as functional outcome. The metabolome was assayed liquid chromatography-mass spectrometry. Results group showed significant differences pupillary light reflex, Coma (GCS) score, Marshall computed tomography (CT) well expression levels 27 metabolites serum. Random forest analysis indicated that Lysophosphatidylcholine (LPC) 22:3 sn-2 carnitine C8:1 greatly contributed to distinguishing from (MeanDecreaseGini: 3.81, 5.16). combined prediction these two yielded an area under curve (AUC) 0.944, which higher than combination parameters. Conclusions serum metabolomics revealed potential biomarkers has value exploring pathogenesis, determining early diagnosis, improving long-term function.

Language: Английский

Citations

0
How can heatstroke damage the brain? A mini review DOI Creative Commons

Kazuhiro Yoneda,

Sanae Hosomi,

Hiroshi Ito

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 10, 2024

Record-breaking heat waves over the past 20 years have led to a global increase in heat-related deaths, including heatstroke. Heat-related illnesses occur when body cannot adapt elevated temperatures environment, leading various symptoms. In severe situations, such as heatstroke, temperature can rise above 40°C, significant injury systems, with particular susceptibility of central nervous system (CNS). Neuroimaging studies conducted months or after heatstroke revealed cellular damage cerebellum and other brain regions, hippocampus, midbrain, thalamus, potential for long-term neurological complications survivors This mini review aimed describe mechanisms pathways underlying development induced by identify diagnostic imaging tools biomarkers CNS due

Language: Английский

Citations

0